From circuits to behaviour in the amygdala

Nature, Journal Year: 2015, Volume and Issue: 517(7534), P. 284 - 292

Published: Jan. 13, 2015

Language: Английский

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The brain reward circuitry in mood disorders

Nature reviews. Neuroscience, Journal Year: 2013, Volume and Issue: 14(9), P. 609 - 625

Published: Aug. 14, 2013

Language: Английский

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Pleasure Systems in the Brain

Neuron, Journal Year: 2015, Volume and Issue: 86(3), P. 646 - 664

Published: May 1, 2015

Language: Английский

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Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(6), P. 335 - 346

Published: May 4, 2017

Language: Английский

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The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action

Annual Review of Psychology, Journal Year: 2014, Volume and Issue: 66(1), P. 25 - 52

Published: Sept. 24, 2014

Nearly 40 years of research on the function nucleus accumbens (NAc) has provided a wealth information its contributions to behavior but also yielded controversies and misconceptions regarding these functions. A primary tenet this review is that, rather than serving as "reward" center, NAc plays key role in action selection, integrating cognitive affective processed by frontal temporal lobe regions augment efficiency vigor appetitively or aversively motivated behaviors. Its involvement functions most prominent when appropriate course ambiguous, uncertain, laden with distractors, state flux. To end, different subregions play dissociable roles refining promoting approach toward motivationally relevant stimuli, suppressing inappropriate actions so that goals may be obtained more efficiently, encoding outcomes guide direction subsequent ones.

Language: Английский

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Resolving the neural circuits of anxiety

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(10), P. 1394 - 1404

Published: Sept. 25, 2015

Language: Английский

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Memory Engram Cells Have Come of Age

Neuron, Journal Year: 2015, Volume and Issue: 87(5), P. 918 - 931

Published: Sept. 1, 2015

Language: Английский

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Anxiety Cells in a Hippocampal-Hypothalamic Circuit

Neuron, Journal Year: 2018, Volume and Issue: 97(3), P. 670 - 683.e6

Published: Jan. 31, 2018

Language: Английский

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The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Pharmacological Reviews, Journal Year: 2016, Volume and Issue: 68(3), P. 816 - 871

Published: June 30, 2016

The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical limbic structures to mediate goal-directed behaviors. Chronic exposure several classes drugs abuse disrupts plasticity in this region, allowing drug-associated cues engender pathologic motivation for drug seeking. A number alterations glutamatergic transmission occur within after withdrawal chronic exposure. These drug-induced neuroadaptations serve as molecular basis relapse vulnerability. In review, we focus on role that glutamate signal transduction plays addiction-related First, explore accumbens, including cell types neuronal populations present well afferent efferent connections. Next discuss rodent models addiction assess viability these testing candidate pharmacotherapies prevention relapse. Then provide review literature describing how synaptic altered also pharmacological manipulation systems can inhibit seeking laboratory setting. Finally, examine results clinical trials which designed manipulate have been effective treating human patients. Further elucidation alter will be necessary development new therapeutics treatment across all addictive substances.

Language: Английский

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Striatal circuits for reward learning and decision-making

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(8), P. 482 - 494

Published: June 6, 2019

Language: Английский

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