Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Nature Communications, Год журнала: 2015, Номер 6(1)

Опубликована: Май 8, 2015

Abstract Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated pathophysiology of depression; however, afferent source this increased glutamate tone is not known. The NAc receives inputs from medial prefrontal cortex (mPFC), ventral hippocampus (vHIP) basolateral amygdala (AMY). Here, we demonstrate that vHIP afferents to regulate susceptibility chronic social defeat stress (CSDS). We observe reduced activity mice resilient CSDS. Furthermore, attenuation vHIP-NAc by optogenetic induction long-term depression pro-resilient, whereas acute enhancement input pro-susceptible. This effect specific NAc, as stimulation either mPFC or AMY pro-resilient. These data indicate uniquely CSDS, highlighting an important, novel circuit-specific mechanism depression.

Язык: Английский

---

Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval

Neuron, Год журнала: 2016, Номер 90(2), С. 348 - 361

Опубликована: Апрель 1, 2016

Язык: Английский

---

Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

Nature, Год журнала: 2017, Номер 543(7643), С. 103 - 107

Опубликована: Фев. 21, 2017

Язык: Английский

---

The ins and outs of the striatum: Role in drug addiction

Neuroscience, Год журнала: 2015, Номер 301, С. 529 - 541

Опубликована: Июнь 24, 2015

Язык: Английский

---

Closed-Loop and Activity-Guided Optogenetic Control

Neuron, Год журнала: 2015, Номер 86(1), С. 106 - 139

Опубликована: Апрель 1, 2015

Язык: Английский

---

A Network Model of the Emotional Brain

Trends in Cognitive Sciences, Год журнала: 2017, Номер 21(5), С. 357 - 371

Опубликована: Март 28, 2017

Язык: Английский

---

Contrasting forms of cocaine-evoked plasticity control components of relapse

Nature, Год журнала: 2014, Номер 509(7501), С. 459 - 464

Опубликована: Май 20, 2014

Язык: Английский

---

A thalamic input to the nucleus accumbens mediates opiate dependence

Nature, Год журнала: 2016, Номер 530(7589), С. 219 - 222

Опубликована: Фев. 1, 2016

Язык: Английский

---

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

Neuron, Год журнала: 2015, Номер 87(5), С. 1063 - 1077

Опубликована: Сен. 1, 2015

The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in motivated behaviors. Prior studies have shown that activation of dynorphin-kappa opioid receptor (KOR) leads to aversive, dysphoria-like behavior. However, endogenous sources dynorphin these circuits remain unknown. We investigated whether neuronal firing NAc is sufficient induce aversive found photostimulation cells ventral shell elicits robust conditioned real-time behavior via KOR activation, contrast, dorsal induced a KOR-mediated place preference was positively reinforcing. These results show previously unknown discrete subregions dynorphin-containing selectively drive opposing Understanding regional specificity by which dynorphinerigic regulate aversion provides insight into behaviors dysregulated stress, reward, psychiatric disease.

Язык: Английский

---

Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress

Biological Psychiatry, Год журнала: 2014, Номер 77(3), С. 212 - 222

Опубликована: Июль 28, 2014

Язык: Английский

---