Synaptic nanomodules underlie the organization and plasticity of spine synapses DOI
Martin Hruska, Nathan T. Henderson, Sylvain J. Le Marchand

и другие.

Nature Neuroscience, Год журнала: 2018, Номер 21(5), С. 671 - 682

Опубликована: Апрель 19, 2018

Язык: Английский

Hippocampal GABAergic Inhibitory Interneurons DOI
Kenneth A. Pelkey, Ramesh Chittajallu, Michael T. Craig

и другие.

Physiological Reviews, Год журнала: 2017, Номер 97(4), С. 1619 - 1747

Опубликована: Сен. 28, 2017

In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects cellular function. Here we provide an overview current state field interneuron research, focusing largely on hippocampus. We discuss recent advances related various cell types, including development maturation, expression subtype-specific voltage- ligand-gated channels, roles in network oscillations. also technological approaches that have permitted high-resolution, examination numerous neural disorders emerging therapeutic strategies ameliorate such pathophysiological conditions. The ultimate goal this review is not a touchstone for field, but help pave way future research by highlighting where gaps our knowledge exist how complete appreciation will aid strategies.

Язык: Английский

Процитировано

780

A Brief History of Long-Term Potentiation DOI Creative Commons
Roger A. Nicoll

Neuron, Год журнала: 2017, Номер 93(2), С. 281 - 290

Опубликована: Янв. 1, 2017

Язык: Английский

Процитировано

745

The AMPA Receptor Code of Synaptic Plasticity DOI Creative Commons
Graham H. Diering, Richard L. Huganir

Neuron, Год журнала: 2018, Номер 100(2), С. 314 - 329

Опубликована: Окт. 1, 2018

Язык: Английский

Процитировано

730

Anti-LGI1 encephalitis DOI
Agnes van Sonderen, Roland D. Thijs,

Elias C. Coenders

и другие.

Neurology, Год журнала: 2016, Номер 87(14), С. 1449 - 1456

Опубликована: Сен. 3, 2016

This nationwide study gives a detailed description of the clinical features and long-term outcome anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis.We collected patients prospectively from October 2013, retrospectively samples sent to our laboratory January 2007. LGI1 antibodies were confirmed with both cell-based assay immunohistochemistry. Clinical information was obtained in interviews their relatives medical records. Initial MRI follow-up revised blindly. Neuropsychological assessment performed those over 2 years.Annual incidence Netherlands 0.83/million. A total 34/38 had limbic encephalitis. Subtle focal seizures (66%, autonomic or dyscognitive) faciobrachial dystonic (FBDS, 47%) mostly occurred before onset memory disturbance. Later disease course, 63% tonic-clonic seizures. showed hippocampal T2 hyperintensity 74% patients. These lesions evolved regularly into mesial temporal sclerosis (44%). Substantial response immunotherapy seen 80%, early slow recovery cognition. At ≥2 years, most surviving reported mild residual cognitive deficit spatial disorientation. 86% persistent amnesia for period. Relapses common (35%) presented up 8 years after initial disease. Two-year case fatality rate 19%.Anti-LGI1 encephalitis is homogenous syndrome, showing FBDS other subtle manifestations, followed by disturbances. Better recognition will lead earlier diagnosis, essential prompt start treatment. Long-term favorable, but relapses are common.

Язык: Английский

Процитировано

537

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle DOI
Luisa de Vivo, Michele Bellesi, William Marshall

и другие.

Science, Год журнала: 2017, Номер 355(6324), С. 507 - 510

Опубликована: Фев. 2, 2017

Synapse remodeling during sleep General activity and information processing while an animal is awake drive synapse strengthening. This counterbalanced by weakening of synapses (see the Perspective Acsády). De Vivo et al. used serial scanning electron microscopy to reconstruct axon-spine interface spine head volume in mouse brain. They observed a substantial decrease size after sleep. The largest relative changes occurred among weak synapses, whereas strong ones remained stable. Diering found that undergo synaptic glutamate receptors sleep-wake cycle, driven immediate early gene Homer1a. In animals, Homer1a accumulates neurons but excluded from high levels noradrenaline. At onset sleep, noradrenaline decline, allowing move excitatory weakening. Science , this issue p. 457 507 ; see also 511

Язык: Английский

Процитировано

530

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity DOI Creative Commons

Menglong Zeng,

Yuan Shang, Yoichi Araki

и другие.

Cell, Год журнала: 2016, Номер 166(5), С. 1163 - 1175.e12

Опубликована: Авг. 1, 2016

Язык: Английский

Процитировано

526

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep DOI
Graham H. Diering, Raja Sekhar Nirujogi, Richard H. Roth

и другие.

Science, Год журнала: 2017, Номер 355(6324), С. 511 - 515

Опубликована: Фев. 2, 2017

Synapse remodeling during sleep General activity and information processing while an animal is awake drive synapse strengthening. This counterbalanced by weakening of synapses (see the Perspective Acsády). De Vivo et al. used serial scanning electron microscopy to reconstruct axon-spine interface spine head volume in mouse brain. They observed a substantial decrease size after sleep. The largest relative changes occurred among weak synapses, whereas strong ones remained stable. Diering found that undergo synaptic glutamate receptors sleep-wake cycle, driven immediate early gene Homer1a. In animals, Homer1a accumulates neurons but excluded from high levels noradrenaline. At onset sleep, noradrenaline decline, allowing move excitatory weakening. Science , this issue p. 457 507 ; see also 511

Язык: Английский

Процитировано

480

Synaptic AMPA receptor composition in development, plasticity and disease DOI
Jeremy M. Henley, Kevin A. Wilkinson

Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(6), С. 337 - 350

Опубликована: Апрель 15, 2016

Язык: Английский

Процитировано

457

Dendritic structural plasticity and neuropsychiatric disease DOI
Marc P. Forrest, Euan Parnell, Peter Penzes

и другие.

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(4), С. 215 - 234

Опубликована: Март 16, 2018

Язык: Английский

Процитировано

424

Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease DOI Creative Commons

Evanthia Nanou,

William A. Catterall

Neuron, Год журнала: 2018, Номер 98(3), С. 466 - 481

Опубликована: Май 1, 2018

Язык: Английский

Процитировано

424