Nature Neuroscience, Год журнала: 2018, Номер 21(5), С. 671 - 682
Опубликована: Апрель 19, 2018
Язык: Английский
Physiological Reviews, Год журнала: 2017, Номер 97(4), С. 1619 - 1747
Опубликована: Сен. 28, 2017
In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects cellular function. Here we provide an overview current state field interneuron research, focusing largely on hippocampus. We discuss recent advances related various cell types, including development maturation, expression subtype-specific voltage- ligand-gated channels, roles in network oscillations. also technological approaches that have permitted high-resolution, examination numerous neural disorders emerging therapeutic strategies ameliorate such pathophysiological conditions. The ultimate goal this review is not a touchstone for field, but help pave way future research by highlighting where gaps our knowledge exist how complete appreciation will aid strategies.
Язык: Английский
Процитировано
780
Neuron, Год журнала: 2017, Номер 93(2), С. 281 - 290
Опубликована: Янв. 1, 2017
Язык: Английский
Процитировано
745
Neuron, Год журнала: 2018, Номер 100(2), С. 314 - 329
Опубликована: Окт. 1, 2018
Язык: Английский
Процитировано
730
Neurology, Год журнала: 2016, Номер 87(14), С. 1449 - 1456
Опубликована: Сен. 3, 2016
This nationwide study gives a detailed description of the clinical features and long-term outcome anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis.We collected patients prospectively from October 2013, retrospectively samples sent to our laboratory January 2007. LGI1 antibodies were confirmed with both cell-based assay immunohistochemistry. Clinical information was obtained in interviews their relatives medical records. Initial MRI follow-up revised blindly. Neuropsychological assessment performed those over 2 years.Annual incidence Netherlands 0.83/million. A total 34/38 had limbic encephalitis. Subtle focal seizures (66%, autonomic or dyscognitive) faciobrachial dystonic (FBDS, 47%) mostly occurred before onset memory disturbance. Later disease course, 63% tonic-clonic seizures. showed hippocampal T2 hyperintensity 74% patients. These lesions evolved regularly into mesial temporal sclerosis (44%). Substantial response immunotherapy seen 80%, early slow recovery cognition. At ≥2 years, most surviving reported mild residual cognitive deficit spatial disorientation. 86% persistent amnesia for period. Relapses common (35%) presented up 8 years after initial disease. Two-year case fatality rate 19%.Anti-LGI1 encephalitis is homogenous syndrome, showing FBDS other subtle manifestations, followed by disturbances. Better recognition will lead earlier diagnosis, essential prompt start treatment. Long-term favorable, but relapses are common.
Язык: Английский
Процитировано
537
Science, Год журнала: 2017, Номер 355(6324), С. 507 - 510
Опубликована: Фев. 2, 2017
Synapse remodeling during sleep General activity and information processing while an animal is awake drive synapse strengthening. This counterbalanced by weakening of synapses (see the Perspective Acsády). De Vivo et al. used serial scanning electron microscopy to reconstruct axon-spine interface spine head volume in mouse brain. They observed a substantial decrease size after sleep. The largest relative changes occurred among weak synapses, whereas strong ones remained stable. Diering found that undergo synaptic glutamate receptors sleep-wake cycle, driven immediate early gene Homer1a. In animals, Homer1a accumulates neurons but excluded from high levels noradrenaline. At onset sleep, noradrenaline decline, allowing move excitatory weakening. Science , this issue p. 457 507 ; see also 511
Язык: Английский
Процитировано
530
Cell, Год журнала: 2016, Номер 166(5), С. 1163 - 1175.e12
Опубликована: Авг. 1, 2016
Язык: Английский
Процитировано
526
Science, Год журнала: 2017, Номер 355(6324), С. 511 - 515
Опубликована: Фев. 2, 2017
Synapse remodeling during sleep General activity and information processing while an animal is awake drive synapse strengthening. This counterbalanced by weakening of synapses (see the Perspective Acsády). De Vivo et al. used serial scanning electron microscopy to reconstruct axon-spine interface spine head volume in mouse brain. They observed a substantial decrease size after sleep. The largest relative changes occurred among weak synapses, whereas strong ones remained stable. Diering found that undergo synaptic glutamate receptors sleep-wake cycle, driven immediate early gene Homer1a. In animals, Homer1a accumulates neurons but excluded from high levels noradrenaline. At onset sleep, noradrenaline decline, allowing move excitatory weakening. Science , this issue p. 457 507 ; see also 511
Язык: Английский
Процитировано
480
Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(6), С. 337 - 350
Опубликована: Апрель 15, 2016
Язык: Английский
Процитировано
457
Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(4), С. 215 - 234
Опубликована: Март 16, 2018
Язык: Английский
Процитировано
424
Neuron, Год журнала: 2018, Номер 98(3), С. 466 - 481
Опубликована: Май 1, 2018
Язык: Английский
Процитировано
424