Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking

Annual Review of Physiology, Год журнала: 2016, Номер 78(1), С. 351 - 365

Опубликована: Фев. 10, 2016

For more than 20 years, we have known that Ca 2+ /calmodulin-dependent protein kinase (CaMKII) activation is both necessary and sufficient for the induction of long-term potentiation (LTP). During this time, tremendous effort has been spent in attempting to understand how CaMKII gives rise phenomenon. Despite such efforts, there much be learned about molecular mechanisms involved LTP downstream activation. In review, highlight recent developments shaped our current thinking underlying discuss important questions remain field.

Язык: Английский

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Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

Neuron, Год журнала: 2017, Номер 94(4), С. 713 - 730

Опубликована: Май 1, 2017

Язык: Английский

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Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain

Neuron, Год журнала: 2014, Номер 85(2), С. 377 - 389

Опубликована: Дек. 31, 2014

Язык: Английский

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Not all brains are created equal: the relevance of individual differences in responsiveness to transcranial electrical stimulation

Frontiers in Systems Neuroscience, Год журнала: 2014, Номер 8

Опубликована: Янв. 1, 2014

A current issue in the research of augmentation brain functions using transcranial electrical stimulation (tES) is diversity and inconsistency outcome results. Similar studies often report different results, depending on parameters tasks used. Such inconsistencies have led to significant doubts about efficacy method broader scientific community, despite its promising potential for patient recovery treatment. Evidence large variability individual cortical excitability response tES suggests that may affect individuals differently, subject's age, gender, state, hormonal levels, pre-existing regional excitability. Certain factors might even lead reversal polarity-dependent effects, therefore crucial implications neurorehabilitation cognitive enhancement. Research paradigms be refined future avoid confounding effects such factors.

Язык: Английский

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Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

Nature, Год журнала: 2017, Номер 549(7672), С. 384 - 388

Опубликована: Сен. 1, 2017

Язык: Английский

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Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity

Biological Psychiatry, Год журнала: 2014, Номер 77(1), С. 52 - 58

Опубликована: Июль 18, 2014

Язык: Английский

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Eligibility Traces and Plasticity on Behavioral Time Scales: Experimental Support of NeoHebbian Three-Factor Learning Rules

Frontiers in Neural Circuits, Год журнала: 2018, Номер 12

Опубликована: Июль 31, 2018

Most elementary behaviors such as moving the arm to grasp an object or walking into next room explore a museum evolve on time scale of seconds; in contrast, neuronal action potentials occur few milliseconds. Learning rules brain must therefore bridge gap between these two different scales. Modern theories synaptic plasticity have postulated that co-activation pre- and postsynaptic neurons sets flag at synapse, called eligibility trace, leads weight change only if additional factor is present while set. This third factor, signaling reward, punishment, surprise, novelty, could be implemented by phasic activity neuromodulators specific inputs special events. While theoretical framework has been developed over last decades, experimental evidence support traces seconds collected during years. Here we review, context three-factor plasticity, four key experiments role combination with biological implementation neoHebbian learning rules.

Язык: Английский

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Signalling scaffolds and local organization of cellular behaviour

Nature Reviews Molecular Cell Biology, Год журнала: 2015, Номер 16(4), С. 232 - 244

Опубликована: Март 18, 2015

Язык: Английский

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Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications

Molecular Psychiatry, Год журнала: 2022, Номер 27(6), С. 2689 - 2699

Опубликована: Март 30, 2022

Язык: Английский

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Rapid Dispersion of SynGAP from Synaptic Spines Triggers AMPA Receptor Insertion and Spine Enlargement during LTP

Neuron, Год журнала: 2015, Номер 85(1), С. 173 - 189

Опубликована: Янв. 1, 2015

Язык: Английский

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