Chinese Medicine, Год журнала: 2024, Номер 19(1)
Опубликована: Окт. 9, 2024
Major depressive disorder (MDD) is one of the most common psychiatric disorders worldwide. Hypericum perforatum (HP) a traditional herb that has been shown to have antidepressant effects, but its mechanism unclear. This study aims identify molecular targets HP for treatment MDD.
Язык: Английский
Molecular Psychiatry, Год журнала: 2022, Номер 28(1), С. 284 - 297
Опубликована: Окт. 6, 2022
Abstract Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different levels point to high complexity numerous interrelated pathways as the underpinnings depression. systems under consideration include monoamines, stress, neurotrophins and neurogenesis, excitatory inhibitory neurotransmission, mitochondrial dysfunction, (epi)genetics, inflammation, opioid system, myelination, gut-brain axis, among others. This review aims illustrating how these multiple signaling may interact provide more comprehensive view MDD’s neurobiology. In particular, considering pattern synaptic activity closest physical representation mood, emotion, conscience we can conceptualize, each pathway or system will be scrutinized for links neurotransmission. Models neurobiology MDD discussed well future actions improve understanding treatment options.
Язык: Английский
Процитировано
241
Physiological Reviews, Год журнала: 2024, Номер 104(3), С. 1205 - 1263
Опубликована: Март 14, 2024
Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.
Язык: Английский
Процитировано
26
Nature Neuroscience, Год журнала: 2025, Номер 28(2), С. 415 - 430
Опубликована: Янв. 6, 2025
Abstract The mammalian dentate gyrus (DG) is involved in certain forms of learning and memory, DG dysfunction has been implicated age-related diseases. Although neurogenic potential maintained throughout life the as neural stem cells (NSCs) continue to generate new neurons, neurogenesis decreases with advancing age, implications for cognitive decline disease. In this study, we used single-cell RNA sequencing characterize transcriptomic signatures their surrounding niche, identifying molecular changes associated aging from activation quiescent NSCs maturation fate-committed progeny. By integrating spatial transcriptomics data, identified regional invasion inflammatory into hippocampus age show here that early-onset neuroinflammation activity. Our data reveal lifelong dynamics niche provide a powerful resource understand alterations hippocampus.
Язык: Английский
Процитировано
2
Frontiers in Neurology, Год журнала: 2022, Номер 13
Опубликована: Ноя. 10, 2022
Depression is a worldwide disease causing severe disability, morbidity, and mortality. Despite abundant studies, the precise mechanisms underlying pathophysiology of depression remain elusive. Recently, cumulate research suggests that disturbance microbiota-gut-brain axis may play vital role in etiology while correcting this could alleviate symptoms. The vagus nerve, linking brain gut through its afferent efferent branches, critical route bidirectional communication axis. Directly or indirectly, fibers can sense relay microbiota signals to induce disorders including depression. Also, changes response stress result hyperpermeability inflammation mediating by vagal efferents, which be detrimental Notably, nerve stimulation owns an anti-inflammatory effect was proved for treatment. Nevertheless, accompanied low tone, derive from contribute pathogenesis In review, we aim explore perspective axis, highlighting relationship among hyperpermeability, inflammation,
Язык: Английский
Процитировано
55
Phytomedicine, Год журнала: 2022, Номер 106, С. 154395 - 154395
Опубликована: Авг. 23, 2022
Sinisan (SNS) consists of four kinds herbs, which is the core antidepressant prescription widely used in traditional Chinese medicine clinic treatment for depression induced by early life stress. However, role and precise mechanism SNS have not yet been elucidated.This study aimed to investigate on regulating mitochondrial function improve hippocampal synaptic plasticity.90 Sprague-Dawley (SD) rats male pups Post-Natal Day (PND) 0 were randomly divided into Control group (ddH20), Model Fluoxetine (5.0 mg/kg fluoxetine), SNS-L (2.5 g/kg SNS), SNS-M SNS) SNS-H (10.0 15 animals per group. Maternal separation (MS) from PND1 PND21, drug intervention PND60 PND90, behavior tests including sucrose preference test, open field test forced swimming PND83 PND90 performed. Synaptic structure observed TEM. The expression levels PSD-95 SYN detected immunohistochemistry western blot adenosine triphosphate (ATP) content hippocampus was assay kits, Mfn2, Drp1 Fis1 protein bolt test.SNS can alleviate depression-like anxiety-like behaviors MS rats, damage synapses mitochondria, reduce decrease ATP hippocampus, reverse PSD-95, SYN, Drp1, proteins.SNS reduced risk stress disorder via plasticity. Targeting may be a novel prospective therapeutic avenue antidepressant.
Язык: Английский
Процитировано
52
Aging, Год журнала: 2023, Номер unknown
Опубликована: Июнь 29, 2023
Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, the relationship between these is bidirectional. The association depression highly co-morbid tends to significantly exacerbate metabolic related depressive symptoms. However, neural mechanism under mutual control of largely inscrutable. This review focuses particularly on alterations in systems that may mechanistically explain vivo homeostatic regulation link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation well neuroendocrine regulators energy metabolism including adipocytokines lipokines. In addition, summarizes potential future treatments for raises several questions need be answered research. will provide a comprehensive description localization biological connection better understand co-morbidity depression.
Язык: Английский
Процитировано
32
Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(49)
Опубликована: Ноя. 27, 2023
The global agri-food system is simultaneously a major contributor to, and severely affected by, climate change. Agroecological farming systems can contribute to creating resilient systems. Based on multiyear qualitative case study, ...Supporting transitions sustainable, important ensure stable food supply in the face of growing extremes. Agroecology, or diversified based ecological principles, such ...
Язык: Английский
Процитировано
31
Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 34(8), С. 446 - 461
Опубликована: Июнь 26, 2023
Язык: Английский
Процитировано
23
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1991 - 1991
Опубликована: Фев. 6, 2024
The hippocampus is a critical brain substrate for learning and memory; events that harm the can seriously impair mental behavioral functioning. Hippocampal pathophysiologies have been identified as potential causes effects of remarkably diverse array medical diseases, psychological disorders, environmental sources damage. It may be more vulnerable than other areas to insults are related these conditions. One purpose this review assess vulnerability most prevalent types in multiple biomedical domains (i.e., neuroactive pathogens, neurotoxins, neurological conditions, trauma, aging, neurodegenerative disease, acquired injury, health endocrine developmental disabilities, nutrition) evaluate whether affect first prominently compared loci. A second consider role hippocampal blood–brain barrier (BBB) breakdown either causing or worsening harmful each insult. Recent research suggests BBB fragile also prone disruption transport mechanisms act maintain internal milieu. Moreover, compromised could factor common many different insults. Our analysis indicates parts brain, developing interventions protect help prevent ameliorate on memory cognition.
Язык: Английский
Процитировано
15
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 3, 2024
Abstract Background Radiation-induced brain injury (RIBI) is a common and severe complication during radiotherapy for head neck tumor. Repetitive transcranial magnetic stimulation (rTMS) novel non-invasive method of stimulation, which has been applied in various neurological diseases. rTMS proved to be effective treatment RIBI, while its mechanisms have not well understood. Methods RIBI mouse model was established by cranial irradiation, K252a daily injected intraperitoneally block BDNF pathway. Immunofluorescence staining, immunohistochemistry western blotting were performed examine the microglial pyroptosis hippocampal neurogenesis. Behavioral tests used assess cognitive function emotionality mice. Golgi staining observe structure dendritic spine hippocampus. Results significantly promoted neurogenesis mitigated neuroinflammation, with ameliorating microglia, as downregulation protein expression level NLRP3 inflammasome key factor Gasdermin D (GSDMD). signaling pathway might involved it. After blocking K252a, specific inhibitor, neuroprotective effect markedly reversed. Evaluated behavioral tests, dysfunction anxiety-like behavior found aggravated comparison mice intervention group. Moreover, attenuated, microglia levels GSDMD, IL-1β upregulated. Conclusion Our study indicated that notably ameliorated RIBI-induced disorders, mitigating promoting via mediating
Язык: Английский
Процитировано
15