Translational Psychiatry,
Год журнала:
2016,
Номер
6(8), С. e863 - e863
Опубликована: Авг. 2, 2016
Abstract
Post-stroke
depression
(PSD)
is
a
common
outcome
following
stroke
that
associated
with
poor
recovery.
To
develop
preclinical
model
of
PSD,
we
targeted
key
node
the
depression–anxiety
circuitry
by
inducing
unilateral
ischemic
lesion
to
medial
prefrontal
cortex
(mPFC)
stroke.
Microinjection
male
C57/BL6
mice
endothelin-1
(ET-1,
1600
pmol)
induced
small
(1
mm
3
)
consistently
localized
within
left
mPFC.
Compared
sham
control
mice,
displayed
robust
behavioral
phenotype
in
four
validated
tests
anxiety
including
elevated
plus
maze,
light–dark,
open-field
and
novelty-suppressed
feeding
tests.
In
addition,
depression-like
behaviors
both
forced
swim
tail
suspension
test.
contrast,
there
was
no
effect
on
locomotor
activity
or
sensorimotor
function
horizontal
ladder,
cylinder
home
cage
tests,
indicating
silent
due
absence
motor
abnormalities.
When
re-tested
at
6
weeks
post
stroke,
retained
phenotypes.
Surprisingly,
site
infiltrated
neurons,
suggesting
ET-1-induced
neuronal
loss
mPFC
reversible
over
time,
but
insufficient
promote
summary,
results
pronounced
persistent
evident
deficits.
This
precise
provides
reproducible
study
adaptive
cellular
changes
efficacy
novel
interventions
alleviate
PSD
symptoms.
Frontiers in Cellular Neuroscience,
Год журнала:
2017,
Номер
11
Опубликована: Март 15, 2017
Ischemic
damage
to
the
brain
triggers
substantial
reorganization
of
spared
areas
and
pathways,
which
is
associated
with
limited,
spontaneous
restoration
function.
A
better
understanding
this
plastic
remodeling
crucial
develop
more
effective
strategies
for
stroke
rehabilitation.
In
review,
we
discuss
advances
in
comprehension
post-stroke
network
patients
animal
models.
We
first
focus
on
rodent
studies
that
have
shed
light
mechanisms
underlying
neuronal
perilesional
area
contralesional
hemisphere
after
motor
cortex
infarcts.
Analysis
electrophysiological
data
has
demonstrated
brain-wide
alterations
functional
connectivity
both
hemispheres,
well
beyond
infarcted
area.
then
illustrate
potential
use
non-invasive
stimulation
techniques
boost
recovery.
finally
rehabilitative
protocols
based
robotic
devices
as
a
tool
promote
endogenous
plasticity
restoration.
Advanced Materials,
Год журнала:
2019,
Номер
31(21)
Опубликована: Апрель 8, 2019
Reperfusion
injury
exists
as
the
major
obstacle
to
full
recovery
of
neuron
functions
after
ischemic
stroke
onset
and
clinical
thrombolytic
therapies.
Complex
cellular
cascades
including
oxidative
stress,
neuroinflammation,
brain
vascular
impairment
occur
within
neurovascular
units,
leading
microthrombus
formation
ultimate
death.
In
this
work,
a
multitarget
micelle
system
is
developed
simultaneously
modulate
various
cell
types
involved
in
these
events.
Briefly,
rapamycin
encapsulated
self-assembled
micelles
that
are
consisted
reactive
oxygen
species
(ROS)-responsive
fibrin-binding
polymers
achieve
retention
controlled
drug
release
lesion.
Neuron
survival
reinforced
by
combination
facilitated
ROS
elimination
antistress
signaling
pathway
interference
under
ischemia
conditions.
vivo
results
demonstrate
an
overall
remodeling
unit
through
polarized
M2
microglia
repair
blood-brain
barrier
preservation,
enhanced
neuroprotection
blood
perfusion.
This
strategy
gives
proof
concept
units
can
serve
integrated
target
for
treatment
with
nanomedicines.
Nature Neuroscience,
Год журнала:
2024,
Номер
27(5), С. 1000 - 1013
Опубликована: Март 26, 2024
Abstract
Although
the
general
location
of
functional
neural
networks
is
similar
across
individuals,
there
vast
person-to-person
topographic
variability.
To
capture
this,
we
implemented
precision
brain
mapping
magnetic
resonance
imaging
methods
to
establish
an
open-source,
method-flexible
set
network
atlases—the
Masonic
Institute
for
Developing
Brain
(MIDB)
Precision
Atlas.
This
atlas
evolving
resource
comprising
53,273
individual-specific
maps,
from
more
than
9,900
ages
and
cohorts,
including
Adolescent
Cognitive
Development
study,
Developmental
Human
Connectome
Project
others.
We
also
generated
probabilistic
maps
multiple
integration
zones
(using
a
new
overlapping
technique,
Overlapping
MultiNetwork
Imaging).
Using
regions
high
invariance
improved
reproducibility
executive
function
statistical
in
brain-wide
associations
compared
group
average-based
parcellations.
Finally,
provide
potential
use
case
targeted
neuromodulation.
The
expandable
alternative
datasets
with
online
interface
encouraging
scientific
community
explore
contribute
understanding
human
precisely.
The Cerebellum,
Год журнала:
2019,
Номер
18(6), С. 1064 - 1097
Опубликована: Июнь 4, 2019
The
cerebellum
is
best
known
for
its
role
in
controlling
motor
behaviors.
However,
recent
work
supports
the
view
that
it
also
influences
non-motor
contribution
of
towards
different
brain
functions
underscored
by
involvement
a
diverse
and
increasing
number
neurological
neuropsychiatric
conditions
including
ataxia,
dystonia,
essential
tremor,
Parkinson's
disease
(PD),
epilepsy,
stroke,
multiple
sclerosis,
autism
spectrum
disorders,
dyslexia,
attention
deficit
hyperactivity
disorder
(ADHD),
schizophrenia.
Although
there
are
no
cures
these
conditions,
cerebellar
stimulation
quickly
gaining
symptomatic
alleviation,
as
circuitry
has
arisen
promising
target
invasive
non-invasive
neuromodulation.
This
consensus
paper
brings
together
experts
from
fields
neurophysiology,
neurology,
neurosurgery
to
discuss
efforts
using
therapeutic
intervention.
We
report
on
most
advanced
techniques
manipulating
circuits
humans
animal
models
define
key
hurdles
questions
moving
forward.
Cerebral Cortex,
Год журнала:
2016,
Номер
26(6), С. 2882 - 2894
Опубликована: Март 14, 2016
Neural
plasticity
is
a
major
factor
driving
cortical
reorganization
after
stroke.
We
here
tested
whether
repetitively
enhancing
motor
cortex
by
means
of
intermittent
theta-burst
stimulation
(iTBS)
prior
to
physiotherapy
might
promote
recovery
function
early
Functional
magnetic
resonance
imaging
(fMRI)
was
used
elucidate
underlying
neural
mechanisms.
Twenty-six
hospitalized,
first-ever
stroke
patients
(time
since
stroke:
1-16
days)
with
hand
deficits
were
enrolled
in
sham-controlled
design
and
pseudo-randomized
into
2
groups.
iTBS
administered
on
5
consecutive
days
either
over
ipsilesional
primary
(M1-stimulation
group)
or
parieto-occipital
vertex
(control-stimulation
group).
Hand
function,
excitability,
resting-state
fMRI
assessed
1
day
the
first
last
stimulation.
Recovery
grip
strength
significantly
stronger
M1-stimulation
compared
control-stimulation
group.
Higher
levels
network
connectivity
associated
better
outcome.
Consistently,
control-stimulated
featured
decrease
intra-
interhemispheric
network,
which
absent
Hence,
adding
prime
recovering
seems
interfere
degradation,
possibly
reflecting
alleviation
post-stroke
diaschisis.
