Social neuroscience: undoing the schism between neurology and psychiatry DOI
Agustín Ibáñez, Adolfo M. García,

Sol Esteves

et al.

Social Neuroscience, Journal Year: 2016, Volume and Issue: 13(1), P. 1 - 39

Published: Oct. 6, 2016

Multiple disorders once jointly conceived as "nervous diseases" became segregated by the distinct institutional traditions forged in neurology and psychiatry. As a result, each field specialized study treatment of subset such conditions. Here we propose new avenues for interdisciplinary interaction through triangulation both fields with social neuroscience. To this end, review evidence from five relevant domains (facial emotion recognition, empathy, theory mind, moral cognition, context assessment), highlighting their common disturbances across neurological psychiatric conditions discussing multiple pathophysiological mechanisms. Our proposal is anchored multidimensional evidence, including behavioral, neurocognitive, genetic findings. From clinical perspective, work paves way dimensional transdiagnostic approaches, pharmacological treatments, educational innovations rooted combined neuropsychiatric training. Research-wise, it fosters models brain novel platform to explore interplay cognitive functions. Finally, identify challenges synergistic framework.

Language: Английский

A cross-disorder connectome landscape of brain dysconnectivity DOI
Martijn P. van den Heuvel, Olaf Sporns

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(7), P. 435 - 446

Published: May 24, 2019

Language: Английский

Citations

397
Intact skull chronic windows for mesoscopic wide-field imaging in awake mice DOI
Gergely Silasi, Dongsheng Xiao, Matthieu P. Vanni

et al.

Journal of Neuroscience Methods, Journal Year: 2016, Volume and Issue: 267, P. 141 - 149

Published: April 22, 2016

Language: Английский

Citations

203
Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation DOI Creative Commons
Claudia Alia, Cristina Spalletti, Stefano Lai

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2017, Volume and Issue: 11

Published: March 15, 2017

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration function. A better understanding this plastic remodeling crucial develop more effective strategies for stroke rehabilitation. In review, we discuss advances in comprehension post-stroke network patients animal models. We first focus on rodent studies that have shed light mechanisms underlying neuronal perilesional area contralesional hemisphere after motor cortex infarcts. Analysis electrophysiological data has demonstrated brain-wide alterations functional connectivity both hemispheres, well beyond infarcted area. then illustrate potential use non-invasive stimulation techniques boost recovery. finally rehabilitative protocols based robotic devices as a tool promote endogenous plasticity restoration.

Language: Английский

Citations

195
Molecular, cellular and functional events in axonal sprouting after stroke DOI
S. Thomas Carmichael, Balachandar Kathirvelu,

Catherine A. Schweppe

et al.

Experimental Neurology, Journal Year: 2016, Volume and Issue: 287, P. 384 - 394

Published: Feb. 11, 2016

Language: Английский

Citations

171
Microthrombus‐Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke DOI
Yifei Lü, Chao Li, Qinjun Chen

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(21)

Published: April 8, 2019

Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, brain vascular impairment occur within neurovascular units, leading microthrombus formation ultimate death. In this work, a multitarget micelle system is developed simultaneously modulate various cell types involved in these events. Briefly, rapamycin encapsulated self-assembled micelles that are consisted reactive oxygen species (ROS)-responsive fibrin-binding polymers achieve retention controlled drug release lesion. Neuron survival reinforced by combination facilitated ROS elimination antistress signaling pathway interference under ischemia conditions. vivo results demonstrate an overall remodeling unit through polarized M2 microglia repair blood-brain barrier preservation, enhanced neuroprotection blood perfusion. This strategy gives proof concept units can serve integrated target for treatment with nanomedicines.

Language: Английский

Citations

146
Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair DOI
Takashi Shichita, Hiroaki Ooboshi, Akihiko Yoshimura

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(5), P. 299 - 312

Published: March 27, 2023

Language: Английский

Citations

59
A precision functional atlas of personalized network topography and probabilities DOI Creative Commons
Robert Hermosillo, Lucille A. Moore, Eric Feczko

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(5), P. 1000 - 1013

Published: March 26, 2024

Abstract Although the general location of functional neural networks is similar across individuals, there vast person-to-person topographic variability. To capture this, we implemented precision brain mapping magnetic resonance imaging methods to establish an open-source, method-flexible set network atlases—the Masonic Institute for Developing Brain (MIDB) Precision Atlas. This atlas evolving resource comprising 53,273 individual-specific maps, from more than 9,900 ages and cohorts, including Adolescent Cognitive Development study, Developmental Human Connectome Project others. We also generated probabilistic maps multiple integration zones (using a new overlapping technique, Overlapping MultiNetwork Imaging). Using regions high invariance improved reproducibility executive function statistical in brain-wide associations compared group average-based parcellations. Finally, provide potential use case targeted neuromodulation. The expandable alternative datasets with online interface encouraging scientific community explore contribute understanding human precisely.

Language: Английский

Citations

24
Post-stroke epilepsy DOI
Tomotaka Tanaka, Masafumi Ihara

Neurochemistry International, Journal Year: 2017, Volume and Issue: 107, P. 219 - 228

Published: Feb. 13, 2017

Language: Английский

Citations

142
Consensus Paper: Experimental Neurostimulation of the Cerebellum DOI Creative Commons
Lauren N. Miterko, Kenneth B. Baker, Jaclyn Beckinghausen

et al.

The Cerebellum, Journal Year: 2019, Volume and Issue: 18(6), P. 1064 - 1097

Published: June 4, 2019

The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor contribution of towards different brain functions underscored by involvement a diverse and increasing number neurological neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), schizophrenia. Although there are no cures these conditions, cerebellar stimulation quickly gaining symptomatic alleviation, as circuitry has arisen promising target invasive non-invasive neuromodulation. This consensus paper brings together experts from fields neurophysiology, neurology, neurosurgery to discuss efforts using therapeutic intervention. We report on most advanced techniques manipulating circuits humans animal models define key hurdles questions moving forward.

Language: Английский

Citations

139
Shaping Early Reorganization of Neural Networks Promotes Motor Function after Stroke DOI Creative Commons
Lukas J. Volz,

AK Rehme,

Jochen Michely

et al.

Cerebral Cortex, Journal Year: 2016, Volume and Issue: 26(6), P. 2882 - 2894

Published: March 14, 2016

Neural plasticity is a major factor driving cortical reorganization after stroke. We here tested whether repetitively enhancing motor cortex by means of intermittent theta-burst stimulation (iTBS) prior to physiotherapy might promote recovery function early Functional magnetic resonance imaging (fMRI) was used elucidate underlying neural mechanisms. Twenty-six hospitalized, first-ever stroke patients (time since stroke: 1-16 days) with hand deficits were enrolled in sham-controlled design and pseudo-randomized into 2 groups. iTBS administered on 5 consecutive days either over ipsilesional primary (M1-stimulation group) or parieto-occipital vertex (control-stimulation group). Hand function, excitability, resting-state fMRI assessed 1 day the first last stimulation. Recovery grip strength significantly stronger M1-stimulation compared control-stimulation group. Higher levels network connectivity associated better outcome. Consistently, control-stimulated featured decrease intra- interhemispheric network, which absent Hence, adding prime recovering seems interfere degradation, possibly reflecting alleviation post-stroke diaschisis.

Language: Английский

Citations

129