Rhythms of the hippocampal network

Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(4), С. 239 - 249

Опубликована: Март 10, 2016

Язык: Английский

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Promises and limitations of human intracranial electroencephalography

Nature Neuroscience, Год журнала: 2018, Номер 21(4), С. 474 - 483

Опубликована: Фев. 27, 2018

Язык: Английский

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Beyond the Status Quo: A Role for Beta Oscillations in Endogenous Content (Re)Activation

eNeuro, Год журнала: 2017, Номер 4(4), С. ENEURO.0170 - 17.2017

Опубликована: Июль 1, 2017

Among the rhythms of brain, oscillations in beta frequency range (∼13-30 Hz) have been considered most enigmatic. Traditionally associated with sensorimotor functions, recently become more broadly implicated top-down processing, long-range communication, and preservation current brain state. Here, we extend refine these views based on accumulating new findings content-specific beta-synchronization during endogenous information processing working memory (WM) decision making. We characterize such activity as short-lived, flexible network dynamics supporting (re)activation cortical representations. Specifically, suggest that beta-mediated ensemble formation within between areas may awake, rather than merely preserve, an cognitive set service task demands. This proposal accommodates key aspects modulations monkeys humans, integrates timely computational models, outlines a functional role for fits its transient temporal characteristics.

Язык: Английский

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Does predictive coding have a future?

Nature Neuroscience, Год журнала: 2018, Номер 21(8), С. 1019 - 1021

Опубликована: Июль 19, 2018

Язык: Английский

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Neural Mechanisms of Sustained Attention Are Rhythmic

Neuron, Год журнала: 2018, Номер 99(4), С. 854 - 865.e5

Опубликована: Авг. 1, 2018

Язык: Английский

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A Rhythmic Theory of Attention

Trends in Cognitive Sciences, Год журнала: 2018, Номер 23(2), С. 87 - 101

Опубликована: Дек. 24, 2018

Язык: Английский

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The graphical brain: Belief propagation and active inference

Network Neuroscience, Год журнала: 2017, Номер 1(4), С. 381 - 414

Опубликована: Июнь 7, 2017

This paper considers functional integration in the brain from a computational perspective. We ask what sort of neuronal message passing is mandated by active inference-and implications this has for context-sensitive connectivity at microscopic and macroscopic levels. In particular, we formulate processing as belief propagation under deep generative models. Crucially, these models can entertain both discrete continuous states, leading to distinct schemes updating that play out on same (neuronal) architecture. Technically, use Forney (normal) factor graphs elucidate requisite terms its form scheduling. To accommodate mixed (of states), one also consider link nodes or factors enable representations talk each other. When mapping implicit architecture onto connectivity, several interesting features emerge. For example, Bayesian model averaging comparison, which may be implemented thalamocortical loops. These other considerations speak connectome inherently state dependent self-organizing ways yield principled (variational) account. conclude with simulations reading illustrate passing, special focus how (semantic) inform, are informed by, (visual) sampling sensorium.

Язык: Английский

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The neurobiology of interoception in health and disease

Annals of the New York Academy of Sciences, Год журнала: 2018, Номер 1428(1), С. 112 - 128

Опубликована: Июль 5, 2018

Abstract Interoception is the sensing of internal bodily sensations. an umbrella term that encompasses (1) afferent (body‐to‐brain) signaling through distinct neural and humoral (including immune endocrine) channels; (2) encoding, representation, integration this information concerning state; (3) influence such on other perceptions, cognitions, behaviors; (4) psychological expression these representations as consciously accessible physical sensations feelings. Interoceptive mechanisms ensure physiological health cerebral coordination homeostatic reflexes allostatic responses include motivational behaviors associated affective emotional Furthermore, conscious, unitary sense self in time space may be grounded primacy lifelong continuity interoception. Body‐to‐brain interactions mental well‐being. Consequently, we show systematic investigation how individual differences, within‐individual changes, interoceptive processing can contribute to mechanistic understanding disorders. We present a neurobiological overview interoception describe impairments at different levels relate specific conditions, including sickness fatigue, depression, eating disorders, autism, anxiety. frame findings predictive framework highlight potential new avenues for treatments.

Язык: Английский

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Brain Rhythms of Pain

Trends in Cognitive Sciences, Год журнала: 2016, Номер 21(2), С. 100 - 110

Опубликована: Дек. 23, 2016

Pain is a vital phenomenon that depends on the dynamic integration of sensory and contextual processes. In chronic pain adaptive processes severely disturbed. Neuronal oscillations synchrony at different frequencies provide evidence information flow across brain areas. The flexible relationship between indicates routing in cerebral processing pain. systematic assessment provides insights into how are flexibly integrated coherent percept abnormalities these Predictive coding frameworks might help us understand an integrative results from interactions (i.e., cognitive, emotional, motivational) experience associated with neuronal frequencies. However, overarching framework for significance remains lacking. Recent concepts relate to signaling predictions prediction errors. application promises coordinates diverse merge Such have implications understanding treatment [1Melzack R. Casey K.L. Sensory, motivational, central control determinants pain: new conceptual model pain.in: Kenshalo D.R.J. Skin Senses. Charles C. Thomas, 1968: 423-439Google Scholar]. thus essentially phenomenon. recent years it has been shown serve functions by [2Schnitzler A. Gross J. Normal pathological oscillatory communication brain.Nat. Rev. Neurosci. 2005; 6: 285-296Crossref PubMed Scopus (618) Google Scholar, 3Akam T. Kullmann D.M. Oscillatory multiplexing population codes selective mammalian 2014; 15: 111-122Crossref (75) 4Fries P. Rhythms cognition: through coherence.Neuron. 2015; 88: 220-235Abstract Full Text PDF (182) 5Saalmann Y.B. et al.The pulvinar regulates transmission cortical areas based attention demands.Science. 2012; 337: 753-756Crossref (298) 6Mejias J.F. al.Feedforward feedback frequency-dependent large-scale laminar network primate cortex.Sci. Adv. 2016; 2: e1601335Crossref Thus, role functionally dynamically health disease. Here we review We begin brief discussion peculiarities its brain. then summarize On this basis specifically discuss factors percept. Moreover, Finally, consider perspectives future directions study unpleasant emotional signals threat promotes behavior protect individual. Commonly, underlying process noxious stimulus induces physiological processes, referred as nociception (see Glossary), translate This translation influenced broad variety factors. routinely make use influence; example, when comforting injured child or harnessing placebo effects therapy. nociceptive mediated feedforward human [7Wiech K. Deconstructing sensation influence cognitive perception.Science. 354: 584-587Crossref (0) not static but be adjusted continuously changing demands everyday life. For same input can yield no competing goal achieved (e.g., during long-distance run) under other conditions result strong severe disease feared). plays preeminent probably exceeds modalities. states, often persists without objective body. Chronic own right affects about fifth adult Western world [8Breivik H. al.Survey Europe: prevalence, impact daily life, treatment.Eur. Pain. 2006; 10: 287-333Crossref (1993) 9Kennedy al.Prevalence persistent U.S. population: data 2010 national interview survey.J. 979-984Abstract (46) Scholar], imposes enormous economic burden society [10Breivik individual societal case strategic prioritisation action improve knowledge availability appropriate care.BMC Public Health. 2013; 13: 1229Crossref (93) 11Gaskin D.J. Richard costs United States.J. 715-724Abstract (470) causes suffering individuals. weak lost [12Baliki M.N. Apkarian A.V. 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It likely activity eventually Structural connections represent anatomical process. adjust momentary behavioral demands, highly flexible. flexibility requires changes timescales provided structural rather connections. recently conceptualized connectome [20Kucyi Davis connectome.Trends 38: 86-95Abstract concept does conceive emphasizes dynamics determine only spatially recruited also complex temporal–spectral patterns activity. pain-related ranging infraslow fluctuations below 0.1 Hz (Box 1) via theta (4–7 Hz), alpha (8–13 beta (14–29 Hz) gamma (30–100 [21Gross al.Gamma primary somatosensory reflect perception.PLoS Biol. 2007; 5: e133Crossref (53) 22Hauck M. al.Attention painful stimulation enhances gamma-band synchronization sensorimotor cortex.J. 27: 9270-9277Crossref (74) 23Mouraux al.Non-phase locked electroencephalogram (EEG) responses CO2 laser skin stimulations may A∂- C-fibre afferent volleys.Clin. 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Язык: Английский

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Frontal Top-Down Signals Increase Coupling of Auditory Low-Frequency Oscillations to Continuous Speech in Human Listeners

Current Biology, Год журнала: 2015, Номер 25(12), С. 1649 - 1653

Опубликована: Май 29, 2015

Язык: Английский

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