Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions

eLife, Год журнала: 2018, Номер 7

Опубликована: Фев. 7, 2018

The simultaneous imaging and manipulating of neural activity could enable the functional dissection circuits. Here we have combined two-photon optogenetics with volumetric calcium to measure manipulate in mouse neocortex vivo three-dimensions (3D) cellular resolution. Using a hybrid holographic approach, simultaneously photostimulate more than 80 neurons over 150 μm depth layer 2/3 visual cortex, while surrounding neurons. We validate usefulness method by photoactivating 3D selected groups interneurons, suppressing response nearby pyramidal stimuli awake animals. Our all-optical approach be used as general platform read write neuronal activity.

Язык: Английский

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Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour

Nature, Год журнала: 2019, Номер 565(7741), С. 645 - 649

Опубликована: Янв. 1, 2019

Язык: Английский

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Adult Hippocampal Neurogenesis, Fear Generalization, and Stress

Neuropsychopharmacology, Год журнала: 2015, Номер 41(1), С. 24 - 44

Опубликована: Июнь 12, 2015

Язык: Английский

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A Systems Neuroscience Approach to Migraine

Neuron, Год журнала: 2018, Номер 97(5), С. 1004 - 1021

Опубликована: Март 1, 2018

Язык: Английский

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Attractor and integrator networks in the brain

Nature reviews. Neuroscience, Год журнала: 2022, Номер 23(12), С. 744 - 766

Опубликована: Ноя. 3, 2022

Язык: Английский

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