Considering sex as a biological variable will require a global shift in science culture

Nature Neuroscience, Год журнала: 2021, Номер 24(4), С. 457 - 464

Опубликована: Март 1, 2021

Язык: Английский

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Towards the neural population doctrine

Current Opinion in Neurobiology, Год журнала: 2019, Номер 55, С. 103 - 111

Опубликована: Март 13, 2019

Язык: Английский

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Hypothalamic CRH neurons orchestrate complex behaviours after stress

Nature Communications, Год журнала: 2016, Номер 7(1)

Опубликована: Июнь 16, 2016

All organisms possess innate behavioural and physiological programmes that ensure survival. In order to have maximum adaptive benefit, these must be sufficiently flexible account for changes in the environment. Here we show hypothalamic CRH neurons orchestrate an environmentally repertoire of behaviours emerge after acute stress mice. Optical silencing disrupts organization individual stress. These patterns shift according environment stress, but this environmental sensitivity is blunted by activation PVN neurons. findings provide evidence cells are part a previously unexplored circuit matches precise context following Overactivity network absence may contribute ambivalence, resulting context-inappropriate strategies.

Язык: Английский

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Behavioral methods to study anxiety in rodents

Dialogues in Clinical Neuroscience, Год журнала: 2017, Номер 19(2), С. 181 - 191

Опубликована: Июнь 30, 2017

Stress is a precipitating factor for anxiety-related disorders, which are among the leading forms of psychiatric illness and impairment in modern world. Rodent-based behavioral tests models widely used to understand mechanisms by stress triggers behaviors identify new treatments disorders. Although substantial progress has been made many key neural circuits molecular pathways mediating responsiveness have characterized, these advances thus far failed translate into fundamentally that safer more efficacious humans. The purpose this article describe methods historically type research highlight approaches align with recent conceptualizations disease symptomatology may ultimately prove be fruitful facilitating development improved therapeutics.

Язык: Английский

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Quantifying behavior to understand the brain

Nature Neuroscience, Год журнала: 2020, Номер 23(12), С. 1537 - 1549

Опубликована: Ноя. 9, 2020

Язык: Английский

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Large-scale neural recordings call for new insights to link brain and behavior

Nature Neuroscience, Год журнала: 2022, Номер 25(1), С. 11 - 19

Опубликована: Янв. 1, 2022

Язык: Английский

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Revealing the structure of pharmacobehavioral space through motion sequencing

Nature Neuroscience, Год журнала: 2020, Номер 23(11), С. 1433 - 1443

Опубликована: Сен. 21, 2020

Язык: Английский

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The Spatiotemporal Organization of the Striatum Encodes Action Space

Neuron, Год журнала: 2017, Номер 95(5), С. 1171 - 1180.e7

Опубликована: Авг. 1, 2017

Язык: Английский

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Zebrafish Behavior: Opportunities and Challenges

Annual Review of Neuroscience, Год журнала: 2017, Номер 40(1), С. 125 - 147

Опубликована: Апрель 4, 2017

A great challenge in neuroscience is understanding how activity the brain gives rise to behavior. The zebrafish an ideal vertebrate model address this challenge, thanks capacity, at larval stage, for precise behavioral measurements, genetic manipulations, and recording manipulation of neural noninvasively single-neuron resolution throughout whole brain. These techniques are being further developed application freely moving animals juvenile stages study more complex behaviors including learning, decision making, social interactions. We review some approaches that have been used behavior point opportunities challenges lie ahead.

Язык: Английский

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Structure of the Zebrafish Locomotor Repertoire Revealed with Unsupervised Behavioral Clustering

Current Biology, Год журнала: 2018, Номер 28(2), С. 181 - 195.e5

Опубликована: Янв. 1, 2018

Язык: Английский

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