Cell, Journal Year: 2021, Volume and Issue: 184(15), P. 4048 - 4063.e32
Published: July 1, 2021
Language: Английский
Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(4), P. 457 - 464
Published: March 1, 2021
Language: Английский
Citations
355
Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 55, P. 103 - 111
Published: March 13, 2019
Language: Английский
Citations
279
Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)
Published: June 16, 2016
All organisms possess innate behavioural and physiological programmes that ensure survival. In order to have maximum adaptive benefit, these must be sufficiently flexible account for changes in the environment. Here we show hypothalamic CRH neurons orchestrate an environmentally repertoire of behaviours emerge after acute stress mice. Optical silencing disrupts organization individual stress. These patterns shift according environment stress, but this environmental sensitivity is blunted by activation PVN neurons. findings provide evidence cells are part a previously unexplored circuit matches precise context following Overactivity network absence may contribute ambivalence, resulting context-inappropriate strategies.
Language: Английский
Citations
272
Dialogues in Clinical Neuroscience, Journal Year: 2017, Volume and Issue: 19(2), P. 181 - 191
Published: June 30, 2017
Stress is a precipitating factor for anxiety-related disorders, which are among the leading forms of psychiatric illness and impairment in modern world. Rodent-based behavioral tests models widely used to understand mechanisms by stress triggers behaviors identify new treatments disorders. Although substantial progress has been made many key neural circuits molecular pathways mediating responsiveness have characterized, these advances thus far failed translate into fundamentally that safer more efficacious humans. The purpose this article describe methods historically type research highlight approaches align with recent conceptualizations disease symptomatology may ultimately prove be fruitful facilitating development improved therapeutics.
Language: Английский
Citations
258
Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(12), P. 1537 - 1549
Published: Nov. 9, 2020
Language: Английский
Citations
256
Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(1), P. 11 - 19
Published: Jan. 1, 2022
Language: Английский
Citations
255
Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(11), P. 1433 - 1443
Published: Sept. 21, 2020
Language: Английский
Citations
249
Neuron, Journal Year: 2017, Volume and Issue: 95(5), P. 1171 - 1180.e7
Published: Aug. 1, 2017
Language: Английский
Citations
249
Annual Review of Neuroscience, Journal Year: 2017, Volume and Issue: 40(1), P. 125 - 147
Published: April 4, 2017
A great challenge in neuroscience is understanding how activity the brain gives rise to behavior. The zebrafish an ideal vertebrate model address this challenge, thanks capacity, at larval stage, for precise behavioral measurements, genetic manipulations, and recording manipulation of neural noninvasively single-neuron resolution throughout whole brain. These techniques are being further developed application freely moving animals juvenile stages study more complex behaviors including learning, decision making, social interactions. We review some approaches that have been used behavior point opportunities challenges lie ahead.
Language: Английский
Citations
241
Current Biology, Journal Year: 2018, Volume and Issue: 28(2), P. 181 - 195.e5
Published: Jan. 1, 2018
Language: Английский
Citations
232