Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(2), С. 73 - 85

Опубликована: Янв. 5, 2017

Язык: Английский

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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Neuron, Год журнала: 2018, Номер 101(1), С. 133 - 151.e7

Опубликована: Ноя. 29, 2018

Язык: Английский

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Genetic Dissection of Neural Circuits: A Decade of Progress

Neuron, Год журнала: 2018, Номер 98(2), С. 256 - 281

Опубликована: Апрель 1, 2018

Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have carried out in a multitude invertebrate vertebrate organisms, linking neurons to behavioral functions. New methods allow systematic classification cell types provide access diverse neuronal for connectivity coding during behavior. Here we evaluate key advances over the past decade discuss future directions.

Язык: Английский

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Neural Circuitry of Reward Prediction Error

Annual Review of Neuroscience, Год журнала: 2017, Номер 40(1), С. 373 - 394

Опубликована: Апрель 25, 2017

Dopamine neurons facilitate learning by calculating reward prediction error, or the difference between expected and actual reward. Despite two decades of research, it remains unclear how dopamine make this calculation. Here we review studies that tackle problem from a diverse set approaches, anatomy to electrophysiology computational modeling behavior. Several patterns emerge synthesis: themselves calculate rather than inherit passively upstream regions; they combine multiple separate redundant inputs, which are interconnected in dense recurrent network; despite complexity output is remarkably homogeneous robust. The more study simple arithmetic computation, knottier appears be, suggesting daunting (but stimulating) path ahead for neuroscience generally.

Язык: Английский

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Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

Physiological Reviews, Год журнала: 2020, Номер 101(2), С. 611 - 681

Опубликована: Сен. 24, 2020

This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.

Язык: Английский

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Striatal and Tegmental Neurons Code Critical Signals for Temporal-Difference Learning of State Value in Domestic Chicks

Frontiers in Neuroscience, Год журнала: 2016, Номер 10

Опубликована: Ноя. 7, 2016

To ensure survival, animals must update the internal representations of their environment in a trial-and-error fashion. Psychological studies associative learning and neurophysiological analyses dopaminergic neurons have suggested that this updating process involves temporal-difference (TD) method basal ganglia network. However, way which component variables TD are implemented at neuronal level is unclear. investigate underlying neural mechanisms, we trained domestic chicks to associate color cues with food rewards. We recorded activities from medial striatum or tegmentum freely behaving condition examined how reward omission changed firing. compare signals assumed method, simulated behavioral task form finite sequence composed discrete steps time. The three were prediction signal, target signal for updating, TD-error signal. In both tegmentum, majority categorized into types according fitness models, though these tended continuum spectrum without distinct differences firing rate. Specifically, two striatal successfully mimicked A linear summation was good fit activity one type tegmental mimicking present study thus demonstrates can convey critically required method. Based on theoretical studies, together tract-tracing data, propose novel model explain convergence represented could lead computation error neurons.

Язык: Английский

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Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function

Neuron, Год журнала: 2017, Номер 94(1), С. 7 - 18

Опубликована: Апрель 1, 2017

Язык: Английский

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Neural Circuit Motifs in Valence Processing

Neuron, Год журнала: 2018, Номер 100(2), С. 436 - 452

Опубликована: Окт. 1, 2018

Язык: Английский

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Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture

Journal of Neuroscience, Год журнала: 2019, Номер 39(42), С. 8239 - 8249

Опубликована: Окт. 16, 2019

The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that prominent component of disparate theories brain function due to its broad noradrenergic projections throughout the CNS. As diffuse system, noradrenaline affects learning decision making, control sleep wakefulness, sensory salience including pain, physiology correlated forebrain activity (ensembles networks) hemodynamic responses. However, our understanding LC undergoing dramatic shift application state-of-the-art methods reveal many modules provide targeted neuromodulation. Here, we review evidence supporting modular based on multiple levels observation (developmental, genetic, molecular, anatomical, neurophysiological). We suggest concept as and, alongside it, role in diverse must be reconsidered.

Язык: Английский

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Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons

Nature Neuroscience, Год журнала: 2018, Номер 21(4), С. 638 - 646

Опубликована: Март 2, 2018

Язык: Английский

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