Neurosteroids as regulators of neuroinflammation DOI Creative Commons
Canelif Yılmaz, Kanelina Karali,

Georgia Fodelianaki

и другие.

Frontiers in Neuroendocrinology, Год журнала: 2019, Номер 55, С. 100788 - 100788

Опубликована: Сен. 9, 2019

Neuroinflammation is a physiological protective response in the context of infection and injury. However, neuroinflammation, especially if chronic, may also drive neurodegeneration. Neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's (PD) traumatic brain injury (TBI), display inflammatory activation microglia astrocytes. Intriguingly, central nervous system (CNS) highly steroidogenic environment synthesizing steroids de novo, well metabolizing deriving from circulation. Neurosteroid synthesis can be substantially affected by while, turn, several steroids, 17β-estradiol, dehydroepiandrosterone (DHEA) allopregnanolone, regulate neuroinflammatory responses. Here, we review role neurosteroids neuroinflammation MS, AD, PD TBI describe underlying molecular mechanisms. Moreover, introduce concept that synthetic neurosteroid analogues could potentially utilized for treatment neurodegenerative diseases future.

Язык: Английский

An astroglial basis of major depressive disorder? An overview DOI
Qian Wang, Wei Jie, Jihong Liu

и другие.

Glia, Год журнала: 2017, Номер 65(8), С. 1227 - 1250

Опубликована: Март 20, 2017

Abstract Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the global population. The monoamine hypothesis has dominated our understanding pharmacotherapy depression for more than half century; however, pathophysiology pathogenesis major lagged far behind. Astrocytes are most abundant versatile cells in brain, participating most, if not all, brain functions as both passive housekeeper an active player. Mounting evidence from clinical, preclinical post‐mortem studies revealed decrease number or density astrocytes morphological functional astroglial atrophy patients with depressive (MDD) animal models depression. Furthermore, currently available antidepressant treatments at least partially exert their therapeutic effects on astrocytes. More importantly, dysfunctional lead depressive‐like phenotypes animals. Together, current point pathology potential root cause MDD. Thus, shift neuron‐centric astrocyte‐centric MDD gained increasing attention during past two decades. Here we will summarize supporting disease astrocyte highlight previous promising strategies directly target development novel treatments.

Язык: Английский

Процитировано

191

Molecular mechanisms of astrocyte-induced synaptogenesis DOI
Katherine T. Baldwin, Çağla Eroğlu

Current Opinion in Neurobiology, Год журнала: 2017, Номер 45, С. 113 - 120

Опубликована: Май 31, 2017

Язык: Английский

Процитировано

190

Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease DOI
Baljit S. Khakh, Vahri Beaumont, Roger Cachope

и другие.

Trends in Neurosciences, Год журнала: 2017, Номер 40(7), С. 422 - 437

Опубликована: Июнь 1, 2017

Язык: Английский

Процитировано

190

Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior DOI Creative Commons
Sónia Guerra‐Gomes, Nuno Sousa, Luísa Pinto

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2018, Номер 11

Опубликована: Янв. 16, 2018

Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological phenotypical features that allow to monitor dynamically respond changes. One hallmarks astrocytic response is generation calcium elevations, which further affect downstream cellular processes. Technical advances field have allowed spatially temporally quantify qualify these elevations. However, impact on brain function remains poorly understood. In this review, we discuss evidences functional heterogeneous events several regions, their consequences synapses, circuits behavior.

Язык: Английский

Процитировано

188

Neurosteroids as regulators of neuroinflammation DOI Creative Commons
Canelif Yılmaz, Kanelina Karali,

Georgia Fodelianaki

и другие.

Frontiers in Neuroendocrinology, Год журнала: 2019, Номер 55, С. 100788 - 100788

Опубликована: Сен. 9, 2019

Neuroinflammation is a physiological protective response in the context of infection and injury. However, neuroinflammation, especially if chronic, may also drive neurodegeneration. Neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's (PD) traumatic brain injury (TBI), display inflammatory activation microglia astrocytes. Intriguingly, central nervous system (CNS) highly steroidogenic environment synthesizing steroids de novo, well metabolizing deriving from circulation. Neurosteroid synthesis can be substantially affected by while, turn, several steroids, 17β-estradiol, dehydroepiandrosterone (DHEA) allopregnanolone, regulate neuroinflammatory responses. Here, we review role neurosteroids neuroinflammation MS, AD, PD TBI describe underlying molecular mechanisms. Moreover, introduce concept that synthetic neurosteroid analogues could potentially utilized for treatment neurodegenerative diseases future.

Язык: Английский

Процитировано

183