Multifunctional materials for implantable and wearable photonic healthcare devices

Nature Reviews Materials, Год журнала: 2020, Номер 5(2), С. 149 - 165

Опубликована: Янв. 7, 2020

Язык: Английский

---

Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics

Advanced Materials, Год журнала: 2021, Номер 34(16)

Опубликована: Дек. 12, 2021

Abstract Medical robots are invaluable players in non‐pharmaceutical treatment of disabilities. Particularly, using prosthetic and rehabilitation devices with human–machine interfaces can greatly improve the quality life for impaired patients. In recent years, flexible electronic soft robotics have attracted tremendous attention this field due to their high biocompatibility, functionality, conformability, low‐cost. Flexible on will make a promising alternative conventional rigid devices, which potentially revolutionize paradigm future direction medical terms feedback user experience. review, fundamental components materials, structures, mechanisms human‐machine summarized by renowned applications five primary areas: physical chemical sensing, physiological recording, information processing communication, robotic actuation, stimulation. This review further concludes discussing outlook current challenges these technologies as interface robotics.

Язык: Английский

---

Battery-free, wireless sensors for full-body pressure and temperature mapping

Science Translational Medicine, Год журнала: 2018, Номер 10(435)

Опубликована: Апрель 4, 2018

Battery-free, soft, skin-mounted wireless sensors enable continuous, full-body spatiotemporal mapping of pressure and temperature on human subjects.

Язык: Английский

---

Wireless and battery-free technologies for neuroengineering

Nature Biomedical Engineering, Год журнала: 2021, Номер 7(4), С. 405 - 423

Опубликована: Март 8, 2021

Язык: Английский

---

Emerging Modalities and Implantable Technologies for Neuromodulation

Cell, Год журнала: 2020, Номер 181(1), С. 115 - 135

Опубликована: Март 26, 2020

Язык: Английский

---

Circuit Investigations With Open-Source Miniaturized Microscopes: Past, Present and Future

Frontiers in Cellular Neuroscience, Год журнала: 2019, Номер 13

Опубликована: Апрель 5, 2019

The ability to simultaneously image the spatiotemporal activity signatures from many neurons during unrestrained vertebrate behaviors has become possible through development of miniaturized fluorescence microscopes, or miniscopes, sufficiently light be carried by small animals such as bats, birds and rodents. Miniscopes have permitted study circuits underlying song vocalization, action sequencing, head-direction tuning, spatial memory encoding sleep name a few. foundation for these microscopes been laid over last two decades academic research with some this work resulting in commercialization. More recently, open-source initiatives led an even broader adoption miniscopes neuroscience community. Open-source designs allow rapid modification extension their function, which resulted new generation that now permit wire-free wireless recording, concurrent electrophysiology imaging, two-color detection, simultaneous optical actuation read-out well wide-field volumetric light-field imaging. These novel will further expand toolset those seeking affordable methods probe neural circuit function naturalistic behaviors. Here, we discuss early development, present use future potential miniscopes.

Язык: Английский

---

3D Printed Functional and Biological Materials on Moving Freeform Surfaces

Advanced Materials, Год журнала: 2018, Номер 30(23)

Опубликована: Апрель 25, 2018

Abstract Conventional 3D printing technologies typically rely on open‐loop, calibrate‐then‐print operation procedures. An alternative approach is adaptive printing, which a closed‐loop method that combines real‐time feedback control and direct ink writing of functional materials in order to fabricate devices moving freeform surfaces. Here, it demonstrated the changes states workspace terms geometries motions target surfaces can be perceived by an integrated robotic system aided computer vision. A hybrid fabrication procedure combining electrical connects with automatic pick‐and‐placing surface‐mounted electronic components yields free‐moving human hand. Using this same approach, cell‐laden hydrogels are also printed live mice, creating model for future studies wound‐healing diseases. This may lead new forms smart manufacturing directly wearable body advanced medical treatments.

Язык: Английский

---

A mm-Sized Wireless Implantable Device for Electrical Stimulation of Peripheral Nerves

IEEE Transactions on Biomedical Circuits and Systems, Год журнала: 2018, Номер 12(2), С. 257 - 270

Опубликована: Март 13, 2018

A wireless electrical stimulation implant for peripheral nerves, achieving >10× improvement over state of the art in depth/volume figure merit, is presented. The fully integrated measures just 2 mm × 3 6.5 (39 ³ , 78 mg), and operates at a large depth 10.5 cm tissue phantom. powered using ultrasound includes miniaturized piezoelectric receiver (piezo), an IC designed 180 nm HV BCD process, off-chip energy storage capacitor, platinum electrodes. package also optional blue light-emitting diode potential applications optogenetic future. system-level design strategy complete operation during charging transient as well unique downlink command/data transfer protocol, enables externally programmable current-controlled with wide range parameters, both (22 to 5000 μA amplitude, ~14 470 μs pulse-width, 0 60 Hz repetition rate) optical (up 23 mW/mm xmlns:xlink="http://www.w3.org/1999/xlink">2 intensity) stimulation. Additionally, achieves 15 V compliance voltage chronic applications. Full integration components, end-to-end vitro system characterizations, results sciatic nerve, demonstrate feasibility efficacy proposed stimulator nerves.

Язык: Английский

---

Flexible and Stretchable Antennas for Biointegrated Electronics

Advanced Materials, Год журнала: 2019, Номер 32(15)

Опубликована: Сен. 6, 2019

Combined advances in material science, mechanical engineering, and electrical engineering form the foundations of thin, soft electronic/optoelectronic platforms that have unique capabilities wireless monitoring control various biological processes cells, tissues, organs. Miniaturized, stretchable antennas represent an essential link between such devices external systems for control, power delivery, data processing, and/or communication. Applications typically involve a demanding set considerations performance, size, stretchability. Some most effective strategies rely on unusual materials as liquid metals, nanowires, woven textiles or optimally configured 2D/3D structures serpentines helical coils conventional materials. In best cases, performance metrics small, stretchable, radio frequency (RF) realized using these compare favorably to those traditional devices. Examples range from dipole, monopole, patch far-field RF operation, magnetic loop near-field communication (NFC), where key parameters include operating frequency, Q factor, radiation pattern, reflection coefficient S11 across deformations cyclic loads. Despite significant progress over last several years, many challenges associated research opportunities remain development high-efficiency biointegrated systems.

Язык: Английский

---

Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain

Proceedings of the National Academy of Sciences, Год журнала: 2018, Номер 115(7)

Опубликована: Янв. 29, 2018

Capabilities for recording neural activity in behaving mammals have greatly expanded our understanding of brain function. Some the most sophisticated approaches use light delivered by an implanted fiber-optic cable to optically excite genetically encoded calcium indicators and record resulting changes fluorescence. Physical constraints induced cables bulk, size, weight associated fixtures complicate studies on natural behaviors, including social interactions movements environments that include obstacles, housings, other complex features. Here, we introduce a wireless, injectable fluorescence photometer integrates miniaturized source photodetector flexible, needle-shaped polymer support, suitable injection into deep at sites interest. The ultrathin geometry compliant mechanics these probes allow minimally invasive implantation stable chronic operation. In vivo freely moving animals demonstrate this technology allows high-fidelity brain, with measurement characteristics match or exceed those fiber photometry systems. capabilities optical recordings neuronal dynamics untethered, potential widespread applications neuroscience research.

Язык: Английский

---