Mechanisms of systems memory consolidation during sleep

Nature Neuroscience, Год журнала: 2019, Номер 22(10), С. 1598 - 1610

Опубликована: Авг. 26, 2019

Язык: Английский

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Sleep Spindles: Mechanisms and Functions

Physiological Reviews, Год журнала: 2019, Номер 100(2), С. 805 - 868

Опубликована: Дек. 5, 2019

Sleep spindles are burstlike signals in the electroencephalogram (EEG) of sleeping mammalian brain and electrical surface correlates neuronal oscillations thalamus. As one most inheritable sleep EEG signatures, probably reflect strength malleability thalamocortical circuits that underlie individual cognitive profiles. We review characteristics, organization, regulation, origins their implication non-rapid-eye-movement (NREMS) its functions, focusing on human rodent. Spatially, spindle-related activity appears scales ranging from small thalamic to functional cortical areas, generates a state favoring intracortical plasticity while limiting output. Temporally, discrete events, part continuous power band, elements grouped an infraslow time scale over which NREMS alternates between continuity fragility. synthesize diverse seemingly unlinked functions for architecture, sensory processing, synaptic plasticity, memory formation, abilities into unifying spindle concept, according 1) generate neural conditions large-scale connectivity outlast appearance as 2) appear preferentially engaged learning attention-based experience during wakefulness, 3) enable selective reactivation routing wake-instated traces areas such hippocampus cortex. Their fine spatiotemporal organization reflects physiological coordinated body may indicate, if not anticipate ultimately differentiate, pathologies neurodevelopmental, -degenerative, -psychiatric conditions.

Язык: Английский

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Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting

Neuron, Год журнала: 2017, Номер 97(1), С. 221 - 230.e4

Опубликована: Дек. 14, 2017

Язык: Английский

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The Brain from Inside Out

Oxford University Press eBooks, Год журнала: 2019, Номер unknown

Опубликована: Июнь 17, 2019

Abstract The Brain from Inside Out takes a critical look at contemporary brain research and reminds us that theoretical framework does matter. Current technology-driven neuroscience is still largely fueled by an empiricist philosophy assuming the brain’s goal to perceive, represent world, learn truth. An inevitable consequence of this assumption decision-making homunculus wedged between our perception actions. In contrast, advocates fundamental function induce actions predict consequences those support survival prosperity host. Brains constantly test their hypotheses producing rather than searching for veridical objective world. Only can provide second opinion about relevance sensory inputs meaning interpretation inputs. inside-out framework, it not sensations teach build up its circuits. Instead, comes with preconfigured self-organized dynamics constrains how acts views Both anatomical physiological organizations are characterized enormous diversity which spans several orders magnitude. two ends continuous landscape give rise apparently distinct qualitative features. A small core strongly interconnected, highly active neurons provides fast “good-enough” answers in needy situations generalizations, whereas detailed precise solutions rely on contribution more isolated sluggish majority. non-egalitarian organization, preexisting nonsense patterns become meaningful through action-based experience. offers alternative strategy investigate operations cognitive faculties, as opposed outside-in approach explores preconceived ideas map onto structures.

Язык: Английский

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Cortical circuit activity underlying sleep slow oscillations and spindles

Proceedings of the National Academy of Sciences, Год журнала: 2018, Номер 115(39)

Опубликована: Сен. 12, 2018

Significance Slow oscillations and spindles are hallmarks of the EEG during slow-wave sleep. They thought to support memory consolidation, particularly in instances where faster spindle nests into “upstate” a slow oscillation. Using two-photon wide-field imaging, we recorded calcium transients from distinct populations cortical excitatory inhibitory neurons sleep mice. Compared with or occurring isolation, events nested oscillation upstate were indeed accompanied by unique pattern activity high pyramidal cell appears concur perisomatic inhibition through parvalbumin-positive interneurons low dendritic somatostatin-positive interneurons. These conditions might foster plasticity.

Язык: Английский

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Oscillating circuitries in the sleeping brain

Nature reviews. Neuroscience, Год журнала: 2019, Номер 20(12), С. 746 - 762

Опубликована: Окт. 15, 2019

Язык: Английский

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Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting

Cell, Год журнала: 2019, Номер 179(2), С. 514 - 526.e13

Опубликована: Окт. 1, 2019

Язык: Английский

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Brain neural patterns and the memory function of sleep

Science, Год журнала: 2021, Номер 374(6567), С. 560 - 564

Опубликована: Окт. 28, 2021

Sleep is crucial for healthy cognition, including memory. The two main phases of sleep, REM (rapid eye movement) and non-REM are associated with characteristic electrophysiological patterns that recorded using surface intracranial electrodes. These include sharp-wave ripples, cortical slow oscillations, delta waves, spindles during sleep theta oscillations sleep. They reflect the precisely timed activity underlying neural circuits. Here, we review how these electrical signatures have been guiding our understanding circuits processes sustaining memory consolidation focusing on hippocampal ripples they coordinate patterns. Finally, highlight brain could also sustain sleep-dependent homeostatic evoke several potential future directions research function

Язык: Английский

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Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Авг. 8, 2019

How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it currently unclear how selective interaction these cardinal oscillations organized support information reactivation transfer. Here, using human intracranial recordings, we demonstrate that prefrontal cortex plays a key role in organizing ripple-mediated transfer during non-rapid eye movement (NREM) sleep. We reveal temporally precise form coupling between slow-wave spindle oscillations, which actively dictates hippocampal-neocortical dialogue Our results suggest model sleeping brain rapid bidirectional interactions, triggered by cortex, mediate activation optimally time subsequent neocortex NREM

Язык: Английский

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Precise Slow Oscillation–Spindle Coupling Promotes Memory Consolidation in Younger and Older Adults

Scientific Reports, Год журнала: 2019, Номер 9(1)

Опубликована: Фев. 13, 2019

Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO; 0.5-1 Hz), spindles (SP), and their coupling across adult human lifespan ask whether observed alterations relate to ability retain associative memories sleep. We demonstrate that older adults do not show fine-tuned fast SPs (12.5-16 Hz) SO peak present younger but, instead, are characterized most by a SP power increase (9-12.5 at end up-state. This increase, typical for adults, coincides with worse memory young age already, whereas tight precision SO-fast promotes adults. Crucially, brain integrity source regions generation, including medial prefrontal cortex, thalamus, hippocampus entorhinal reinforces this beneficial SO-SP old age. Our results reveal cognitive functioning is only determined maintaining structural lifespan, but also preservation interactions enable declarative memories.

Язык: Английский

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