Global waves synchronize the brain’s functional systems with fluctuating arousal

Science Advances, Год журнала: 2021, Номер 7(30)

Опубликована: Июль 21, 2021

Traveling waves spatiotemporally organize brain-wide activity in synchrony with ongoing arousal fluctuations.

Язык: Английский

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Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Nature Neuroscience, Год журнала: 2022, Номер 25(8), С. 1059 - 1070

Опубликована: Июль 7, 2022

Язык: Английский

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Sleep—A brain-state serving systems memory consolidation

Neuron, Год журнала: 2023, Номер 111(7), С. 1050 - 1075

Опубликована: Апрель 1, 2023

Язык: Английский

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Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

Brain, Год журнала: 2020, Номер 143(8), С. 2341 - 2368

Опубликована: Март 2, 2020

Abstract Absence seizures in children and teenagers are generally considered relatively benign because of their non-convulsive nature the large incidence remittance early adulthood. Recent studies, however, show that 30% with absence pharmaco-resistant 60% affected by severe neuropsychiatric comorbid conditions, including impairments attention, cognition, memory mood. In particular, attention deficits can be detected before epilepsy diagnosis, may persist even when pharmacologically controlled aggravated valproic acid monotherapy. New functional MRI-magnetoencephalography MRI-EEG studies provide conclusive evidence changes blood oxygenation level-dependent signal amplitude frequency specific cortical networks at least 1 min start a seizure, spike-wave discharges not generalized seizure onset abnormal network states remain during interictal periods. From neurobiological perspective, recent electrical recordings imaging neuronal ensembles single-cell resolution non-anaesthetized models that, contrast to predominant opinion, mechanisms, rather than an exclusively thalamic rhythmogenesis, key driving ictogenesis determining frequency. Though synchronous ictal firing characterizes activity population level, individual cortico-thalamic thalamocortical neurons sparsely recruited successive consecutive paroxysmal cycles within seizure. strengthens previous findings on essential role for basal ganglia seizures, particular increase substantia nigra GABAergic neurons. Thus, feature is powerful inhibition originates from two sources, reticular nucleus. This undoubtedly provides major contribution decrease total T-type calcium channel-mediated burst neurons, though latter expression. Moreover, some animal enhanced loss-of-function astrocytic GABA transporter GAT-1 does necessarily derive mutation its gene. Together, these novel clinical experimental bring about paradigm-shifting views our understanding demand careful choice initial monotherapy continuous evaluation children. These issues discussed here focus future research help identify therapeutic targets treating both comorbidities.

Язык: Английский

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Noradrenergic circuit control of non-REM sleep substates

Current Biology, Год журнала: 2021, Номер 31(22), С. 5009 - 5023.e7

Опубликована: Окт. 14, 2021

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity inhibited during non-rapid-eye-movement (NREMS). However, sensory vigilance persists NREMS animals and humans, suggesting that wake promotion could remain functional. Here, we demonstrate consolidated mouse a brain state with recurrent fluctuations of the neurotransmitter noradrenaline on ∼50-s timescale thalamus. These occurred around mean levels greater than ones quiet wakefulness, while (NA) declined steeply REMS. They coincided clustering spindle rhythms forebrain heart-rate variations, both which are correlates arousability. We addressed origins these by using closed-loop optogenetic locus coeruleus (LC) activation or inhibition timed moments low high NREMS. suppress, lock, entrain sleep-spindle fore- hindbrain-projecting LC neurons show coordinated infraslow variations natural Noradrenergic modulation thalamic, but not cortical, circuits was required for involved NA release into primary reticular thalamic nuclei activated α1- β-adrenergic receptors cause slowly decaying membrane depolarizations. signaling constitutes vigilance-promoting mechanism renders mammalian disruption close-to-minute through sustaining thalamocortical autonomic arousability.Video abstracthttps://www.cell.com/cms/asset/ab9ec3b8-a3f1-470e-8a9c-a2d6ebebc742/mmc3.mp4Loading ...(mp4, 35.34 MB) Download video

Язык: Английский

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Endogenous memory reactivation during sleep in humans is clocked by slow oscillation-spindle complexes

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Май 25, 2021

Abstract Sleep is thought to support memory consolidation via reactivation of prior experiences, with particular electrophysiological sleep signatures (slow oscillations (SOs) and spindles) gating the information flow between relevant brain areas. However, empirical evidence for a role endogenous (i.e., without experimentally delivered cues) in humans lacking. Here, we devised paradigm which participants acquired associative memories before taking nap. Multivariate decoding was then used capture during non-rapid eye movement (NREM) surface EEG recordings. Our results reveal learning material SO-spindle complexes, precision coupling predicting strength. Critically, strength (i.e. classifier favor previously studied stimulus category) turn predicts level across participants. These elucidate function emphasize importance SOs spindles clocking processes.

Язык: Английский

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How coupled slow oscillations, spindles and ripples coordinate neuronal processing and communication during human sleep

Nature Neuroscience, Год журнала: 2023, Номер 26(8), С. 1429 - 1437

Опубликована: Июль 10, 2023

Abstract Learning and plasticity rely on fine-tuned regulation of neuronal circuits during offline periods. An unresolved puzzle is how the sleeping brain, in absence external stimulation or conscious effort, coordinates firing rates (FRs) communication within across to support synaptic systems consolidation. Using intracranial electroencephalography combined with multiunit activity recordings from human hippocampus surrounding medial temporal lobe (MTL) areas, we show that, governed by slow oscillation (SO) up-states, sleep spindles set a timeframe for ripples occur. This sequential coupling leads stepwise increase (1) FRs, (2) short-latency cross-correlations among local assemblies (3) cross-regional MTL interactions. Triggered SOs spindles, thus establish optimal conditions spike-timing-dependent These results unveil specific rhythms orchestrates processing sleep.

Язык: Английский

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Overnight neuronal plasticity and adaptation to emotional distress

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(4), С. 253 - 271

Опубликована: Март 5, 2024

Язык: Английский

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Consciousness and sleep

Neuron, Год журнала: 2024, Номер 112(10), С. 1568 - 1594

Опубликована: Май 1, 2024

Язык: Английский

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Coupled sleep rhythms for memory consolidation

Trends in Cognitive Sciences, Год журнала: 2024, Номер 28(4), С. 339 - 351

Опубликована: Март 4, 2024

How do passing moments turn into lasting memories? Sheltered from external tasks and distractions, sleep constitutes an optimal state for the brain to reprocess consolidate previous experiences. Recent work suggests that consolidation is governed by intricate interaction of slow oscillations (SOs), spindles, ripples – electrophysiological rhythms orchestrate neuronal processing communication within across memory circuits. This review describes how sequential SO–spindle–ripple coupling provides a temporally spatially fine-tuned mechanism selectively strengthen target memories hippocampal cortical networks. Coupled might be harnessed not only enhance overnight retention, but also combat decline associated with healthy ageing neurodegenerative diseases.

Язык: Английский

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