NeuroImage Clinical,
Год журнала:
2018,
Номер
19, С. 581 - 598
Опубликована: Янв. 1, 2018
White
matter
plasticity
occurs
throughout
life
due
to
learning
and
can
be
a
protective
factor
against
as
well
vulnerability
for
the
development
of
mental
disorders.
In
this
systematic
review
we
summarize
findings
on
structural
white
changes
in
children
adults
with
posttraumatic
stress
disorder
(PTSD)
relate
them
theoretical
accounts
pathophysiology
PTSD
focus
disturbed
processing
contexts
associated
problems
emotional
cognitive
symptomatology.
We
particularly
examine
studies
reporting
fractional
anisotropy
(FA)
measured
diffusion
tensor
imaging
(DTI).
further
subdivided
adult-onset
traumatic
experience
adulthood,
childhood
PTSD.
included
30
comprising
almost
1700
participants
450
300
suffering
from
Our
showed
that
trauma,
decrease
FA
corpus
collosum,
most
prominently
anterior
posterior
midbody,
isthmus
splenium
were
reported.
For
part
cingulum,
superior
longitudinal
fasciculus
frontal
regions
found.
Using
GingerAle,
also
performed
coordinate-based
meta-analysis
14
adulthood
did
not
find
any
significant
clusters.
results
suggest
microstructure
vary
depending
are
brain
circuits
related
contexts.
Finally,
present
methodological
considerations
future
studies.
Cells,
Год журнала:
2019,
Номер
8(11), С. 1424 - 1424
Опубликована: Ноя. 12, 2019
Oligodendrocytes
are
the
myelinating
cells
of
central
nervous
system
(CNS)
that
generated
from
oligodendrocyte
progenitor
(OPC).
OPC
distributed
throughout
CNS
and
represent
a
pool
migratory
proliferative
adult
can
differentiate
into
oligodendrocytes.
The
function
oligodendrocytes
is
to
generate
myelin,
which
an
extended
membrane
cell
wraps
tightly
around
axons.
Due
this
energy
consuming
process
associated
high
metabolic
turnover
vulnerable
cytotoxic
excitotoxic
factors.
Oligodendrocyte
pathology
therefore
evident
in
range
disorders
including
multiple
sclerosis,
schizophrenia
Alzheimer's
disease.
Deceased
be
replenished
lost
myelin
regenerated
during
remyelination,
prevent
axonal
degeneration
restore
function.
Cell
population
studies
have
recently
identified
novel
immunomodulatory
functions
oligodendrocytes,
implications
which,
e.g.,
for
diseases
with
primary
pathology,
not
yet
clear.
Here,
we
review
journey
embryonic
stage
their
role
homeostasis
fate
We
will
also
discuss
most
common
models
used
study
describe
newly
discovered
Science,
Год журнала:
2022,
Номер
378(6619), С. 505 - 510
Опубликована: Ноя. 3, 2022
There
is
more
to
brain
connections
than
the
mere
transfer
of
signals
between
regions.
Behavior
and
cognition
emerge
through
cortical
area
interaction.
This
requires
integration
local
distant
areas
orchestrated
by
densely
connected
networks.
Brain
determine
brain's
functional
organization.
The
imaging
in
living
has
provided
an
opportunity
identify
driving
factors
behind
neurobiology
cognition.
Connectivity
differences
species
among
humans
have
furthered
understanding
evolution
diverging
cognitive
profiles.
pathologies
amplify
this
variability
disconnections
and,
consequently,
disintegration
functions.
prediction
long-term
symptoms
now
preferentially
based
on
disconnections.
paradigm
shift
will
reshape
our
maps
challenge
current
models.
Proceedings of the National Academy of Sciences,
Год журнала:
2018,
Номер
115(50)
Опубликована: Ноя. 28, 2018
Significance
Remyelination
of
the
CNS
is
a
critical
process
in
restoring
function
and
protecting
nerve
fibers
from
degeneration
multiple
sclerosis
other
demyelinating
diseases.
It
currently
thought
that
myelin
can
only
be
repaired
by
generation
new
oligodendrocytes
progenitor
cells
remaining
mature
are
unable
to
participate.
Here
we
show,
using
unique
large
animal
models,
including
nonhuman
primate,
partially
injured
participate
repair.
The
capacity
remyelinate
disease
remains
unknown,
yet
it
provides
an
additional
cell
source
for
recruitment
Molecular Psychiatry,
Год журнала:
2020,
Номер
26(1), С. 103 - 117
Опубликована: Ноя. 3, 2020
Abstract
Depression
is
a
common
mental
illness,
affecting
more
than
300
million
people
worldwide.
Decades
of
investigation
have
yielded
symptomatic
therapies
for
this
disabling
condition
but
not
led
to
consensus
about
its
pathogenesis.
There
are
data
support
several
different
theories
causation,
including
the
monoamine
hypothesis,
hypothalamic–pituitary–adrenal
axis
changes,
inflammation
and
immune
system
alterations,
abnormalities
neurogenesis
conducive
environmental
milieu.
Research
in
these
areas
others
has
greatly
advanced
current
understanding
depression;
however,
there
other,
less
widely
known
Oligodendrocyte
lineage
cells,
oligodendrocyte
progenitor
cells
mature
oligodendrocytes,
numerous
important
functions,
which
include
forming
myelin
sheaths
that
enwrap
central
nervous
axons,
supporting
axons
metabolically,
mediating
certain
forms
neuroplasticity.
These
specialized
glial
been
implicated
psychiatric
disorders
such
as
depression.
In
review,
we
summarize
recent
findings
shed
light
on
how
might
participate
pathogenesis
depression,
discuss
new
approaches
targeting
novel
strategy
treat
Several
MRI
measures
have
been
proposed
as
in
vivo
biomarkers
of
myelin,
each
with
applications
ranging
from
plasticity
to
pathology.
Despite
the
availability
these
myelin-sensitive
modalities,
specificity
and
sensitivity
a
matter
discussion.
Debate
about
which
measure
is
most
suitable
for
quantifying
myelin
still
ongoing.
In
this
study,
we
performed
systematic
review
published
quantitative
validation
studies
clarify
how
different
are
when
compared
underlying
histology.
We
analyzed
results
43
applying
meta-analysis
tools,
controlling
study
sample
size
using
interactive
visualization
(
https://neurolibre.github.io/myelin-meta-analysis
).
report
overall
estimates
prediction
intervals
coefficient
determination
find
that
MT
relaxometry-based
exhibit
highest
correlations
content.
also
show
are,
not
statistically
regarding
their
relationship
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 21, 2025
Neural
interface
technologies
are
increasingly
evolving
towards
bio-inspired
approaches
to
enhance
integration
and
long-term
functionality.
Recent
strategies
merge
soft
materials
with
tissue
engineering
realize
biologically-active
and/or
cell-containing
living
layers
at
the
tissue-device
that
enable
seamless
biointegration
novel
cell-mediated
therapeutic
opportunities.
This
review
maps
field
of
electronics
discusses
key
recent
developments
in
tissue-like
regenerative
bioelectronics,
from
biomaterials
surface-functionalized
bioactive
coatings
'biohybrid'
'all-living'
interfaces.
We
define
contextualize
terminology
this
emerging
highlight
how
biological
components
can
bridge
gap
clinical
translation.
