Frontiers in Neuroscience,
Journal Year:
2018,
Volume and Issue:
12
Published: Oct. 26, 2018
Cannabinoid-based
interventions
are
being
explored
for
a
range
of
central
nervous
system
(CNS)
pathologies
such
as
neurodegeneration,
demyelination,
epilepsy,
stroke,
and
trauma.
As
many
these
disease
states
involve
dysregulation
myelin
integrity
and/or
remyelination,
it
is
important
to
consider
effects
the
endocannabinoid
on
oligodendrocytes
their
precursors.
To
date,
cannabinoid
ligands
modulators
have
been
shown
promote
cell
signaling
in
oligodendrocyte
precursor
survival,
proliferation,
migration
differentiation,
mature
survival
myelination.
In
this
review,
we
examine
research
reports
components
precursors,
with
focus
therapeutic
implications.
Cells,
Journal Year:
2019,
Volume and Issue:
8(11), P. 1424 - 1424
Published: Nov. 12, 2019
Oligodendrocytes
are
the
myelinating
cells
of
central
nervous
system
(CNS)
that
generated
from
oligodendrocyte
progenitor
(OPC).
OPC
distributed
throughout
CNS
and
represent
a
pool
migratory
proliferative
adult
can
differentiate
into
oligodendrocytes.
The
function
oligodendrocytes
is
to
generate
myelin,
which
an
extended
membrane
cell
wraps
tightly
around
axons.
Due
this
energy
consuming
process
associated
high
metabolic
turnover
vulnerable
cytotoxic
excitotoxic
factors.
Oligodendrocyte
pathology
therefore
evident
in
range
disorders
including
multiple
sclerosis,
schizophrenia
Alzheimer's
disease.
Deceased
be
replenished
lost
myelin
regenerated
during
remyelination,
prevent
axonal
degeneration
restore
function.
Cell
population
studies
have
recently
identified
novel
immunomodulatory
functions
oligodendrocytes,
implications
which,
e.g.,
for
diseases
with
primary
pathology,
not
yet
clear.
Here,
we
review
journey
embryonic
stage
their
role
homeostasis
fate
We
will
also
discuss
most
common
models
used
study
describe
newly
discovered
Science,
Journal Year:
2022,
Volume and Issue:
378(6619), P. 505 - 510
Published: Nov. 3, 2022
There
is
more
to
brain
connections
than
the
mere
transfer
of
signals
between
regions.
Behavior
and
cognition
emerge
through
cortical
area
interaction.
This
requires
integration
local
distant
areas
orchestrated
by
densely
connected
networks.
Brain
determine
brain's
functional
organization.
The
imaging
in
living
has
provided
an
opportunity
identify
driving
factors
behind
neurobiology
cognition.
Connectivity
differences
species
among
humans
have
furthered
understanding
evolution
diverging
cognitive
profiles.
pathologies
amplify
this
variability
disconnections
and,
consequently,
disintegration
functions.
prediction
long-term
symptoms
now
preferentially
based
on
disconnections.
paradigm
shift
will
reshape
our
maps
challenge
current
models.
Proceedings of the National Academy of Sciences,
Journal Year:
2018,
Volume and Issue:
115(50)
Published: Nov. 28, 2018
Significance
Remyelination
of
the
CNS
is
a
critical
process
in
restoring
function
and
protecting
nerve
fibers
from
degeneration
multiple
sclerosis
other
demyelinating
diseases.
It
currently
thought
that
myelin
can
only
be
repaired
by
generation
new
oligodendrocytes
progenitor
cells
remaining
mature
are
unable
to
participate.
Here
we
show,
using
unique
large
animal
models,
including
nonhuman
primate,
partially
injured
participate
repair.
The
capacity
remyelinate
disease
remains
unknown,
yet
it
provides
an
additional
cell
source
for
recruitment
Molecular Psychiatry,
Journal Year:
2020,
Volume and Issue:
26(1), P. 103 - 117
Published: Nov. 3, 2020
Abstract
Depression
is
a
common
mental
illness,
affecting
more
than
300
million
people
worldwide.
Decades
of
investigation
have
yielded
symptomatic
therapies
for
this
disabling
condition
but
not
led
to
consensus
about
its
pathogenesis.
There
are
data
support
several
different
theories
causation,
including
the
monoamine
hypothesis,
hypothalamic–pituitary–adrenal
axis
changes,
inflammation
and
immune
system
alterations,
abnormalities
neurogenesis
conducive
environmental
milieu.
Research
in
these
areas
others
has
greatly
advanced
current
understanding
depression;
however,
there
other,
less
widely
known
Oligodendrocyte
lineage
cells,
oligodendrocyte
progenitor
cells
mature
oligodendrocytes,
numerous
important
functions,
which
include
forming
myelin
sheaths
that
enwrap
central
nervous
axons,
supporting
axons
metabolically,
mediating
certain
forms
neuroplasticity.
These
specialized
glial
been
implicated
psychiatric
disorders
such
as
depression.
In
review,
we
summarize
recent
findings
shed
light
on
how
might
participate
pathogenesis
depression,
discuss
new
approaches
targeting
novel
strategy
treat
Several
MRI
measures
have
been
proposed
as
in
vivo
biomarkers
of
myelin,
each
with
applications
ranging
from
plasticity
to
pathology.
Despite
the
availability
these
myelin-sensitive
modalities,
specificity
and
sensitivity
a
matter
discussion.
Debate
about
which
measure
is
most
suitable
for
quantifying
myelin
still
ongoing.
In
this
study,
we
performed
systematic
review
published
quantitative
validation
studies
clarify
how
different
are
when
compared
underlying
histology.
We
analyzed
results
43
applying
meta-analysis
tools,
controlling
study
sample
size
using
interactive
visualization
(
https://neurolibre.github.io/myelin-meta-analysis
).
report
overall
estimates
prediction
intervals
coefficient
determination
find
that
MT
relaxometry-based
exhibit
highest
correlations
content.
also
show
are,
not
statistically
regarding
their
relationship
Ageing & Longevity,
Journal Year:
2025,
Volume and Issue:
1.2025, P. 6 - 21
Published: Jan. 17, 2025
Neuroglia
of
the
central
nervous
system,
represented
by
astroglia,
oligodendroglia
and
microglia,
are
fundamental
for
life-long
support
homeostasis,
plasticity
defence
neural
tissue.
In
particular
neuroglial
cells
contribute
to
cognitive
reserve,
which
defines
neurological
outcome
both
physiological
pathological
ageing.
Physiological
ageing
is
accompanied
with
structural
functional
decline
neuroglia.
particular,
astrocytes
undergo
morphological
atrophy
asthenia
compromises
their
vital
functions
such
as
glutamate
clearance,
K+
buffering
synaptic
support.
Old
oligodendrocytes
lose
myelination
capacity,
results
in
thinning
myelin
sheath
white
matter.
Finally,
associated
accumulation
dystrophic
microglia
limits
neuroprotection.
Age-dependent
impedes
contributes
impairment,
increases
vulnerability
system
neurodegeneration.
Life
style
changes
positively
impact
on
structure
function
this
improving
longevity.
Keywords:
ageing;
longevity;
neuroglia,
oligodendroglia;
oligodendroglial
precursor
cells;
