A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction DOI Open Access
Antoine Bechara, Kent Berridge, Warren K. Bickel

и другие.

Psychological Science in the Public Interest, Год журнала: 2019, Номер 20(2), С. 96 - 127

Опубликована: Окт. 1, 2019

Two major questions about addictive behaviors need to be explained by any worthwhile neurobiological theory. First, why do people seek drugs in the first place? Second, some who use seem eventually become unable resist drug temptation and so "addicted"? We will review theories of addiction that address negative-reinforcement views (i.e., taking opioids alleviate distress or withdrawal), positive-reinforcement for euphoria), habit growth automatic drug-use routines), incentive-sensitization excessive "wanting" take as a result dopamine-related sensitization), cognitive-dysfunction impaired prefrontal top-down control), including those involving competing neurobehavioral decision systems (CNDS), role insula modulating craving. In special case opioids, particular attention is paid whether their analgesic effects overlap with reinforcing perceived low risk legal medicinal which are often prescribed health professional, could play use. Specifically, we issue predisposition vulnerability becoming addicted question experiment develop an addiction, while others not). Finally, attempts novel therapeutic strategies policy ideas help prevent opioid other substance abuse.

Язык: Английский

Brain default-mode network dysfunction in addiction DOI Creative Commons
Rui Zhang, Nora D. Volkow

NeuroImage, Год журнала: 2019, Номер 200, С. 313 - 331

Опубликована: Июнь 21, 2019

Aberrant patterns of brain functional connectivity in the default mode network (DMN) have been observed across different classes substance use disorder (SUD) and are associated with craving relapse. In addicted individuals resting (RSFC) anterior DMN, which participates attribution personal value emotional regulation, tends to be decreased, whereas RSFC posterior directs attention internal world, increased. within DMN is believed contribute impaired self-awareness, negative emotions ruminations addiction. Additionally, disrupted between cortical regions involved executive function, memory emotion could critical drug-taking regardless consequences stress-triggered At system level, dynamics interactions control salience networks also disturbed The prominently engaged during withdrawal preoccupation phases addiction cycle at expense an enhanced participation network. contrast, prominence appears transitorily decreased intoxication phases. There growing evidence that disruption reflects part changes dopaminergic, glutamatergic, GABAergic signaling acute chronic drug use. Findings starting reveal as a potential biomarker for predicting clinical outcomes SUD identify promising target treatment

Язык: Английский

Процитировано

309
A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study DOI Creative Commons
Murat Yücel, Erin Oldenhof, Serge H. Ahmed

и другие.

Addiction, Год журнала: 2018, Номер 114(6), С. 1095 - 1109

Опубликована: Авг. 22, 2018

The US National Institutes of Mental Health Research Domain Criteria (RDoC) seek to stimulate research into biologically validated neuropsychological dimensions across mental illness symptoms and diagnoses. RDoC framework comprises 39 functional constructs designed be revised refined, with the overall goal improving diagnostic validity treatments. This study aimed reach a consensus among experts in addiction field on 'primary' most relevant substance behavioural addictions.Forty-four were recruited from Australia, Asia, Europe Americas. Delphi technique was used determine as degree importance each construct understanding essential underpinning addictive behaviours. Expert opinions canvassed online over three rounds (97% completion rate), consecutive round offering feedback for review their opinions.Seven endorsed by ≥ 80% behaviour: five Positive Valence System (reward valuation, expectancy, action selection, reward learning, habit); one Cognitive Control (response selection/inhibition); expert-initiated (compulsivity). These rated related differentially stages cycle, some linked more closely onset others chronicity. Experts agreed that these apply range addictions.The offers novel neuropsychologically informed theoretical framework, well cogent step forward test transdiagnostic concepts research, direct implications assessment, diagnosis, staging disorder, treatment.

Язык: Английский

Процитировано

203
Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum DOI
Robert F. Krueger, Kelsey A. Hobbs, Christopher Conway

и другие.

World Psychiatry, Год журнала: 2021, Номер 20(2), С. 171 - 193

Опубликована: Май 18, 2021

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address limitations traditional mental disorder diagnoses. These include arbitrary boundaries between and normality, co‐occurrence in the modal case, heterogeneity presentation within dis­orders, instability diagnosis patients. This paper reviews evidence on validity utility disinhibited externalizing antagonistic spectra HiTOP, which together constitute a broad superspectrum. are composed elements subsumed variety disorders described recent DSM nosologies, including most notably substance use “Cluster B” personality disorders. superspectrum ranges from normative levels impulse control self‐assertion, maladaptive disinhibition antagonism, extensive polysubstance involvement psychopathology. A rich literature supports superspectrum, spectra. encompasses common genetic influences, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, treatment response. structure these validators mirrors phenotypic with some correlates more specific or spectra, others relevant entire underlining hierarchical domain. Compared diagnostic categories, conceptualization shows improved utility, reliability, explanatory capacity, clinical applicability. one aspect general approach psychopathology offered by HiTOP can make classification useful both research clinic.

Язык: Английский

Процитировано

202
Structural and functional correlates of smartphone addiction DOI

Juliane Horvath,

Christina Mundinger,

Mike M. Schmitgen

и другие.

Addictive Behaviors, Год журнала: 2020, Номер 105, С. 106334 - 106334

Опубликована: Фев. 1, 2020

Язык: Английский

Процитировано

153
Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis DOI
Sensen Song, Anna Zilverstand, Wenjun Gui

и другие.

Brain stimulation, Год журнала: 2018, Номер 12(3), С. 606 - 618

Опубликована: Дек. 27, 2018

Язык: Английский

Процитировано

148
Cognition and addiction DOI Creative Commons
Antonio Verdejo‐García, Gloria García–Fernández, Geert Dom

и другие.

Dialogues in Clinical Neuroscience, Год журнала: 2019, Номер 21(3), С. 281 - 290

Опубликована: Сен. 30, 2019

In this targeted review, we summarize current knowledge on substance-use disorder (SUD)-related cognitive deficits, the link between these deficits and clinical outcomes, training, remediation, pharmacological approaches that have potential to rescue cognition. We conclude that: (i) people with SUDs moderate in memory, attention, executive functions, decision-making (including reward expectancy, valuation, learning); (ii) higher-order functions are significant predictors of relapse; (iii) training programs targeting reward-related appetitive biases, remediation strategies goal-based decision-making, pharmacotherapies impulsivity SUD-related deficits. suggest avenues for future research, including developing brief, clinically oriented harmonized testing suites improve individualized prediction treatment outcomes; computational modeling can achieve deep phenotyping subtypes likely respond different interventions; phenotype-targeted cognitive, pharmacological, combined interventions. a tentative model neuroscience-informed precision medicine.

Язык: Английский

Процитировано

134
Dopamine and addiction: what have we learned from 40 years of research DOI
Marcello Solinas, Pauline Belujon, Pierre‐Olivier Fernagut

и другие.

Journal of Neural Transmission, Год журнала: 2018, Номер 126(4), С. 481 - 516

Опубликована: Дек. 19, 2018

Язык: Английский

Процитировано

130
Neurobiology of cue-reactivity, craving, and inhibitory control in non-substance addictive behaviors DOI
Stephanie Antons, Matthias Brand, Marc N. Potenza

и другие.

Journal of the Neurological Sciences, Год журнала: 2020, Номер 415, С. 116952 - 116952

Опубликована: Май 31, 2020

Язык: Английский

Процитировано

112
The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex DOI Open Access
Ahmet O. Ceceli, Charles W. Bradberry, Rita Z. Goldstein

и другие.

Neuropsychopharmacology, Год журнала: 2021, Номер 47(1), С. 276 - 291

Опубликована: Авг. 18, 2021

Язык: Английский

Процитировано

106
Compulsive alcohol seeking results from a failure to disengage dorsolateral striatal control over behavior DOI Open Access
Chiara Giuliano, David Belin, Barry J. Everitt

и другие.

Journal of Neuroscience, Год журнала: 2019, Номер unknown, С. 2615 - 18

Опубликована: Янв. 7, 2019

The acquisition of drug, including alcohol, use is associated with activation the mesolimbic dopamine system. However, over course drug exposure control seeking progressively devolves to anterior dorsal striatum (aDLS) dopamine-dependent mechanisms. causal importance this functional recruitment aDLS in switch from controlled compulsive vulnerable individuals remains be established. Here we tested hypothesis that individual differences susceptibility alcohol predicts and underlies development seeking. Male alcohol-preferring rats, phenotype which was confirmed an intermittent two-bottle choice procedure, were implanted bilaterally cannulae above trained instrumentally on a seeking–taking chained schedule reinforcement until some developed behavior. behavior investigated before after compulsivity by measuring extent bilateral infusions receptor antagonist α-flupenthixol (0, 5, 10, 15 μg/side) decreased at different stages training, as follows: (1) instrumental taking responses for alcohol; (2) alcohol-seeking well established; (3) punishment-resistant Only alcohol-seeking, not alcohol-taking, became dependent dopamine. Further, marked blockade actually predicted vulnerability develop seeking, but only subjects control. SIGNIFICANCE STATEMENT Over addictive exposure, there transition ventral mechanisms, it unclear whether causally involved We reliance emergence identified established behavior, mechanisms also showed subsequent Thus, those whom depended subsequently display compulsivity.

Язык: Английский

Процитировано

93