Journal of Neuroscience,
Год журнала:
2018,
Номер
38(44), С. 9402 - 9413
Опубликована: Окт. 31, 2018
Motor
and
premotor
cortices
are
crucial
for
the
control
of
movements.
However,
we
still
know
little
about
how
these
areas
contribute
to
higher-order
motor
control,
such
as
deciding
which
movements
make
when
them.
Here
focus
on
rodent
studies
review
recent
findings,
suggest
that-in
addition
control-neurons
in
play
a
role
sensory
integration,
behavioral
strategizing,
working
memory,
decision-making.
We
that
seemingly
disparate
functions
may
subserve
an
evolutionarily
conserved
sensorimotor
cognition
further
study
could
major
contribution
our
understanding
evolution
function
mammalian
frontal
cortex.
Annual Review of Neuroscience,
Год журнала:
2020,
Номер
43(1), С. 249 - 275
Опубликована: Июль 8, 2020
Significant
experimental,
computational,
and
theoretical
work
has
identified
rich
structure
within
the
coordinated
activity
of
interconnected
neural
populations.
An
emerging
challenge
now
is
to
uncover
nature
associated
computations,
how
they
are
implemented,
what
role
play
in
driving
behavior.
We
term
this
computation
through
population
dynamics.
If
successful,
framework
will
reveal
general
motifs
quantitatively
describe
dynamics
implement
computations
necessary
for
goal-directed
Here,
we
start
with
a
mathematical
primer
on
dynamical
systems
theory
analytical
tools
apply
perspective
experimental
data.
Next,
highlight
some
recent
discoveries
resulting
from
successful
application
systems.
focus
studies
spanning
motor
control,
timing,
decision-making,
working
memory.
Finally,
briefly
discuss
promising
lines
investigation
future
directions
framework.
Humans
process
information
hierarchically.
In
the
presence
of
hierarchies,
sources
failures
are
ambiguous.
resolve
this
ambiguity
by
assessing
their
confidence
after
one
or
more
attempts.
To
understand
neural
basis
reasoning
strategy,
we
recorded
from
dorsomedial
frontal
cortex
(DMFC)
and
anterior
cingulate
(ACC)
monkeys
in
a
task
which
negative
outcomes
were
caused
either
misjudging
stimulus
covert
switch
between
two
stimulus-response
contingency
rules.
We
found
that
both
areas
harbored
representation
evidence
supporting
rule
switch.
Additional
perturbation
experiments
revealed
ACC
functioned
downstream
DMFC
was
directly
specifically
involved
inferring
switches.
These
results
reveal
computational
principles
hierarchical
reasoning,
as
implemented
cortical
circuits.
