A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity DOI Creative Commons
Xuetao Qi, Kun Cui, Yu Zhang

и другие.

Cell Reports, Год журнала: 2022, Номер 41(11), С. 111833 - 111833

Опубликована: Дек. 1, 2022

Pain chronicity involves unpleasant experience in both somatosensory and affective aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However, whether specific PFC neuronal ensembles underlie pain remains elusive. Here we identify a nociceptive ensemble dorsomedial (dmPFC), which shows prominent reactivity to stimuli. We observed that this distinct molecular characteristics is densely connected pain-related regions including basolateral amygdala (BLA) lateral parabrachial nuclei (LPB). Prolonged chemogenetic activation of ensemble, but not randomly transfected subset dmPFC neurons, induces chronic pain-like behaviors normal mice. By contrast, silencing neurons relieves hypersensitivity anxiety mice inflammatory pain. These results suggest presence processing information regulating chronicity.

Язык: Английский

Cell type–differential modulation of prefrontal cortical GABAergic interneurons on low gamma rhythm and social interaction DOI Creative Commons
Ling Liu, Haifeng Xu, Jun Wang

и другие.

Science Advances, Год журнала: 2020, Номер 6(30)

Опубликована: Июль 22, 2020

Prefrontal cortical PV INs and SST differentially regulate low gamma rhythms social interaction behavior.

Язык: Английский

Процитировано

70
State-dependent encoding of exploratory behaviour in the amygdala DOI
María Sol Fustiñana, Tobias Eichlisberger, Tewis Bouwmeester

и другие.

Nature, Год журнала: 2021, Номер 592(7853), С. 267 - 271

Опубликована: Март 3, 2021

Язык: Английский

Процитировано

52
Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex DOI
Bin Yu, Bo Yuan, Jiankun Dai

и другие.

Neuroscience Bulletin, Год журнала: 2020, Номер 36(6), С. 570 - 584

Опубликована: Март 7, 2020

Язык: Английский

Процитировано

51
Neural circuit pathology driven by Shank3 mutation disrupts social behaviors DOI Creative Commons
Sunwhi Kim,

Yong-Eun Kim,

Inuk Song

и другие.

Cell Reports, Год журнала: 2022, Номер 39(10), С. 110906 - 110906

Опубликована: Июнь 1, 2022

Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic mechanisms underlying social dysfunction are largely unknown. Here, we demonstrate circuit-selective mutation (ctMUT) of ASD-risk Shank3 gene within unidirectional projection the prefrontal cortex to basolateral amygdala alters spine morphology and excitatory-inhibitory balance circuit. ctMUT mice show reduced as well elevated neural activity its amplitude variability, which consistent with neuroimaging results human ASD patients. Moreover, circuit hyper-activity disrupts temporal correlation socially tuned neurons events interactions. Finally, optogenetic activation wild-type partially recapitulates mice, while inhibition rescues behavior. Collectively, these highlight circuit-level mechanism drives dysfunction.

Язык: Английский

Процитировано

33
A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity DOI Creative Commons
Xuetao Qi, Kun Cui, Yu Zhang

и другие.

Cell Reports, Год журнала: 2022, Номер 41(11), С. 111833 - 111833

Опубликована: Дек. 1, 2022

Pain chronicity involves unpleasant experience in both somatosensory and affective aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However, whether specific PFC neuronal ensembles underlie pain remains elusive. Here we identify a nociceptive ensemble dorsomedial (dmPFC), which shows prominent reactivity to stimuli. We observed that this distinct molecular characteristics is densely connected pain-related regions including basolateral amygdala (BLA) lateral parabrachial nuclei (LPB). Prolonged chemogenetic activation of ensemble, but not randomly transfected subset dmPFC neurons, induces chronic pain-like behaviors normal mice. By contrast, silencing neurons relieves hypersensitivity anxiety mice inflammatory pain. These results suggest presence processing information regulating chronicity.

Язык: Английский

Процитировано

33