The Interaction of Person-Affect-Cognition-Execution (I-PACE) model for addictive behaviors: Update, generalization to addictive behaviors beyond internet-use disorders, and specification of the process character of addictive behaviors

Neuroscience & Biobehavioral Reviews, Год журнала: 2019, Номер 104, С. 1 - 10

Опубликована: Июнь 24, 2019

We propose an updated version of the Interaction Person-Affect-Cognition-Execution (I-PACE) model, which we argue to be valid for several types addictive behaviors, such as gambling, gaming, buying-shopping, and compulsive sexual behavior disorders. Based on recent empirical findings theoretical considerations, that behaviors develop a consequence interactions between predisposing variables, affective cognitive responses specific stimuli, executive functions, inhibitory control decision-making. In process associations cue-reactivity/craving diminished contribute development habitual behaviors. An imbalance structures fronto-striatal circuits, particularly ventral striatum, amygdala, dorsolateral prefrontal areas, may relevant early stages dorsal striatum later processes. The I-PACE model provide foundation future studies clinical practice. Future should investigate common unique mechanisms involved in addictive, obsessive-compulsive-related, impulse-control, substance-use

Язык: Английский

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Obsessive–compulsive disorder

Nature Reviews Disease Primers, Год журнала: 2019, Номер 5(1)

Опубликована: Авг. 1, 2019

Язык: Английский

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Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?

Translational Psychiatry, Год журнала: 2022, Номер 12(1)

Опубликована: Янв. 10, 2022

Abstract Obsessive-compulsive disorder (OCD) is a highly disabling mental illness that can be divided into frequent primary and rarer organic secondary forms. Its association with autoimmune triggers was introduced through the discovery of Pediatric Autoimmune Neuropsychiatric Disorder Associated Streptococcal infection (PANDAS) Acute onset Syndrome (PANS). encephalitis systemic diseases or other brain diseases, such as multiple sclerosis, have also been reported to sometimes present obsessive-compulsive symptoms (OCS). Subgroups patients OCD show elevated proinflammatory cytokines autoantibodies against targets include basal ganglia. In this conceptual review paper, clinical manifestations, pathophysiological considerations, diagnostic investigations, treatment approaches immune-related are summarized. The novel concept “autoimmune OCD” proposed for small subgroup patients, signs based on PANDAS/PANS criteria from recent experience psychosis suggested. Red flag could (sub)acute onset, unusual age atypical presentation OCS neuropsychiatric features (e.g., disproportionate cognitive deficits) accompanying neurological movement disorders), autonomic dysfunction, resistance, associations symptom infections group A streptococcus, comorbid malignancies. Clinical investigations may reveal alterations increased levels anti-basal ganglia dopamine receptor antibodies inflammatory changes in neuroimaging. Based these red signs, possible, probable, definite subtype proposed.

Язык: Английский

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From compulsivity to compulsion: the neural basis of compulsive disorders

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(5), С. 313 - 333

Опубликована: Апрель 9, 2024

Язык: Английский

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Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 8, 2024

Abstract Compulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying not clearly defined. Here we show that basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to manifestation compulsive-like behaviors. We revealed BLA neurons projecting DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with neuronal population responds aversive predator stress, widely used anxiogenic stressor. Specific optogenetic BLA-DMS induced strong anxiety response followed by compulsive grooming. Furthermore, developed mouse model for compulsivity displaying wide spectrum chronically activating circuit. In these mice, persistent molecular changes at synapses were causally related phenotypes. Together, our study demonstrates involvement emergence enduring via its synaptic changes.

Язык: Английский

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Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized, controlled trial

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 5, 2024

Abstract Obsessive-compulsive disorder (OCD) is associated with a high disease burden, and treatment options are limited. We used intensified electrical stimulation in two dosages to target main circuitry the pathophysiology of OCD, left dorsolateral prefrontal cortex (l-DLPFC), pre-supplementary motor area (pre-SMA) assessed clinical outcomes, neuropsychological performance, brain physiology. In double-blind, randomized controlled trial, thirty-nine patients OCD were randomly assigned three groups sham, 2-mA, or 1-mA transcranial direct current (tDCS) targeting l-DLPFC (F3) pre-SMA (FC2) anodal cathodal respectively. The included 10 sessions 20-minute delivered twice per day 20-min between-session intervals. Outcome measures reduction symptoms, anxiety, depressive states, performance on test battery (response inhibition, working memory, attention), oscillatory activities, functional connectivity. All outcome except EEG examined at pre-intervention, post-intervention, 1-month follow-up times. 2-mA protocol significantly reduced depression states improved quality life after intervention up compared sham group, while symptoms only state immediately following intervention. Both protocols partially response attention bias OCD-related stimuli reaction time memory performance. increased alpha power, decreased delta power as well. connectivity higher frequency bands frontal-central areas sham. Modulation prefrontal-supplementary network tDCS ameliorates results beneficial cognitive effects. resulted larger symptom more converging variables related therapeutic efficacy. These support applying prefrontal-SMA trials.

Язык: Английский

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Deep brain stimulation for psychiatric disorders: From focal brain targets to cognitive networks

NeuroImage, Год журнала: 2020, Номер 225, С. 117515 - 117515

Опубликована: Ноя. 1, 2020

Deep brain stimulation (DBS) is a promising intervention for treatment-resistant psychiatric disorders, particularly major depressive disorder (MDD) and obsessive-compulsive (OCD). Up to 90% of patients who have not recovered with therapy or medication reported benefit from DBS in open-label studies. Response rates randomized controlled trials (RCTs), however, been much lower. This has argued arise surgical variability between sites, recent research focused on refining targeting through personalized imaging. Much less attention given the fact that disorders dysfunction distributed networks, likely acts by altering communication within those networks. part because relies subjective rating scales make it difficult identify network biomarkers. Here, we overview RCT results OCD MDD, as well follow-on imaging We present evidence new approach studying DBS' mechanisms action, measuring objective cognitive/emotional deficits underpin these many other mental disorders. Further, suggest focus cognition could lead reliable biomarkers at an electrophysiologic level, especially related inter-regional synchrony local field potential (LFP). Developing neuroscience finally unlock this highly specific therapy.

Язык: Английский

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High-frequency neuromodulation improves obsessive–compulsive behavior

Nature Medicine, Год журнала: 2021, Номер 27(2), С. 232 - 238

Опубликована: Янв. 18, 2021

Язык: Английский

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Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder

Biological Psychiatry, Год журнала: 2021, Номер 90(10), С. 678 - 688

Опубликована: Июль 19, 2021

Obsessive-compulsive disorder is among the most disabling psychiatric disorders. Although deep brain stimulation considered an effective treatment, its use in clinical practice not fully established. This is, at least part, due to ambiguity about best suited target and insufficient knowledge underlying mechanisms. Recent advances suggest that changes broader networks are responsible for improvement of obsessions compulsions, rather than local impact site. These findings were fueled by innovative methodological approaches using connectivity analyses combination with neuromodulatory interventions. Such a connectomic approach neuromodulation constitutes integrative account aims characterize optimal networks. In this critical review, we integrate from studies interventions neural network presumably reducing compulsions. To end, scrutinize methodologies seemingly conflicting aim merge observations identify common diverse pathways treating obsessive-compulsive disorder. Ultimately, propose unified that—when modulated means cortical or subcortical interventions—alleviates symptoms.

Язык: Английский

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A limbic circuitry involved in emotional stress-induced grooming

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Май 8, 2020

Abstract Prolonged exposure to negative stressors could be harmful if a subject cannot respond appropriately. Strategies evolved stress, including repetitive displacement behaviours, are important in maintaining behavioural homoeostasis. In rodents, self-grooming is frequently observed behaviour believed contribute post-stress de-arousal with adaptive value. Here we identified rat limbic di-synaptic circuit that regulates stress-induced positive affective valence. This links hippocampal ventral subiculum lateral septum (LSv) and then hypothalamus tuberal nucleus. Optogenetic activation of this triggers delayed but robust excessive grooming patterns closely resembling those evoked by emotional stress. Consistently, the neural activity LSv reaches peak before while inhibition significantly suppresses triggered Our results uncover previously unknown circuitry involved regulating pinpoint critical role ethologically behaviour.

Язык: Английский

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