Crosstalk between the subiculum and sleep–wake regulation: A review DOI Creative Commons
Sadegh Rahimi,

Leesa Joyce,

Thomas Fenzl

и другие.

Journal of Sleep Research, Год журнала: 2024, Номер 33(5)

Опубликована: Янв. 9, 2024

Summary The circuitry underlying the initiation, maintenance, and coordination of wakefulness, rapid eye movement sleep, non‐rapid sleep is not thoroughly understood. Sleep thought to arise due decreased activity in ascending reticular arousal system, which originates brainstem awakens thalamus cortex during wakefulness. Despite conventional association sleep–wake states with hippocampal rhythms, mutual influence formation regulating vigilance has been largely neglected. Here, we focus on subiculum, main output region formation. particulary ventral part, sends extensive monosynaptic projections crucial regions implicated regulation, including thalamus, lateral hypothalamus, tuberomammillary nucleus, basal forebrain, ventrolateral preoptic tegmental area, suprachiasmatic nucleus. Additionally, second‐order from subiculum are received by laterodorsal locus coeruleus, median raphe suggesting potential involvement regulation cycle. We also discuss alterations observed individuals disorders sleep‐deprived mice, underscoring significance investigating neuronal communication between pathways promoting both

Язык: Английский

The evolution of the concept of stress and the framework of the stress system DOI Creative Commons

Siyu Lu,

Fang Wei, Guolin Li

и другие.

Cell Stress, Год журнала: 2021, Номер 5(6), С. 76 - 85

Опубликована: Май 31, 2021

Stress is a central concept in biology and has now been widely used psychological, physiological, social, even environmental fields. However, the of stress was cross-utilized to refer different elements system including stressful stimulus, stressor, response, effect. Here, we summarized evolution framework system. We find although developed from Selye's "general adaptation syndrome", it expanded evolved significantly. defined as state homeostasis being challenged, both local stress. A specific stressor may potentially bring about stress, while intensity beyond threshold commonly activate hypothalamic-pituitary-adrenal axis result systematic response. The indicates that includes three types: sustress (inadequate stress), eustress (good distress (bad stress). Both might impair normal physiological functions lead pathological conditions, benefit health through hormesis-induced optimization homeostasis. Therefore, an optimal level essential for building biological shields guarantee life processes.

Язык: Английский

Процитировано

142
Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways DOI Creative Commons

Candace Alicia Rizzi-Wise,

Dong V. Wang

eNeuro, Год журнала: 2021, Номер 8(6), С. ENEURO.0315 - 21.2021

Опубликована: Ноя. 1, 2021

Abstract The lateral septum (LS) is implicated as a hub that regulates variety of affects, such reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated structure homogeneity, exhibits multifaceted functions. Emerging evidence suggests different functions LS are mediated largely by its diverse input output connections. It has also become clear heterogeneous region, where dorsal ventral poles play dissociable often opposing roles. This functional heterogeneity can be explained distinct hippocampal inputs along dorsoventral axis, well antagonizing connections between subregions. Similarly, outputs from subregions to respective downstream targets, hypothalamic, preoptic, tegmental areas, account for this heterogeneity. In review, we provide an updated perspective on subregion classification, connectivity, We identify key questions have yet addressed in field.

Язык: Английский

Процитировано

108
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model DOI Creative Commons

Guangjian Qi,

Pei Zhang, Tongxia Li

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Янв. 31, 2022

Abstract Emotional stress is considered a severe pathogenetic factor of psychiatric disorders. However, the circuit mechanisms remain largely unclear. Using three-chamber vicarious social defeat (3C-VSDS) model in mice, we here show that chronic emotional (CES) induces anxiety-like behavior and transient interaction changes. Dopaminergic neurons ventral tegmental area (VTA) are required to control this behavioral deficit. VTA dopaminergic neuron hyperactivity induced by CES involved innate anxiogenic environment. Chemogenetic activation directly triggers behavior, while chemogenetic inhibition these promotes resilience CES-induced behavior. Moreover, receiving nucleus accumbens (NAc) projections activated mice. Bidirectional modulation NAc-VTA mimics or reverses In conclusion, propose critically establishes regulates This study not only characterizes preclinical representative nuanced aspect CES, but also provides insight circuit-level neuronal processes underlie empathy-like

Язык: Английский

Процитировано

84
Endocannabinoids, cannabinoids and the regulation of anxiety DOI
Gavin N. Petrie, Andrei S. Nastase, Robert J. Aukema

и другие.

Neuropharmacology, Год журнала: 2021, Номер 195, С. 108626 - 108626

Опубликована: Июнь 8, 2021

Язык: Английский

Процитировано

63
Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice DOI Creative Commons
Radhika Rawat, Elif Tunc‐Ozcan,

Tammy L. McGuire

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Май 12, 2022

Abstract Ketamine treatment decreases depressive symptoms within hours, but the mechanisms mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity of adult-born immature granule neurons (ABINs) in mouse hippocampal dentate gyrus is both necessary and sufficient for ketamine. activates ABINs parallel with its behavioral stressed unstressed mice. Chemogenetic inhibition ABIN blocks ketamine, indicating this effects. Conversely, chemogenetic activation without any change neuron numbers mimics cellular increased These findings thus identify a specific cell population mediates actions can potentially be targeted to limit ketamine’s side while preserving therapeutic efficacy.

Язык: Английский

Процитировано

53
Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice DOI Creative Commons
Yun Feng Zhang,

Jialiang Wu,

Yingqi Wang

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Окт. 28, 2023

Abstract The ventral striatum is a reward center implicated in the pathophysiology of depression. It contains islands Calleja, clusters dopamine D3 receptor-expressing granule cells, predominantly olfactory tubercle (OT). These OT neurons regulate self-grooming, repetitive behavior manifested affective disorders. Here we show that chronic restraint stress (CRS) induces robust depression-like behaviors mice and decreases excitability neurons. Ablation or inhibition these leads to behaviors, whereas their activation ameliorates CRS-induced behaviors. Moreover, has rewarding effect, which diminishes when grooming blocked. Finally, propose model explains how may influence release via synaptic connections with spiny projection (SPNs) project midbrain Our study reveals crucial role bidirectionally mediating suggesting potential therapeutic target.

Язык: Английский

Процитировано

25
Procoagulant, antibacterial and antioxidant high-strength porous hydrogel adhesives in situ formed via self-gelling hemostatic microsheets for emergency hemostasis and wound repair DOI
Y. Shan, Feng Cao, Xin Zhao

и другие.

Biomaterials, Год журнала: 2024, Номер 315, С. 122936 - 122936

Опубликована: Окт. 31, 2024

Язык: Английский

Процитировано

12
Microglia-Derived Insulin-like Growth Factor 1 Is Critical for Neurodevelopment DOI Creative Commons

Dominika Rusin,

Lejla Vahl Becirovic, Gabriela Teresa Lyszczarz

и другие.

Cells, Год журнала: 2024, Номер 13(2), С. 184 - 184

Опубликована: Янв. 18, 2024

Insulin-like growth factor 1 (IGF-1) is a peptide hormone essential for the proper development and of organism, as complete knockout

Язык: Английский

Процитировано

11
Ventral striatal islands of Calleja neurons control grooming in mice DOI
Yun Feng Zhang, Luigim Vargas Cifuentes, Katherine N. Wright

и другие.

Nature Neuroscience, Год журнала: 2021, Номер 24(12), С. 1699 - 1710

Опубликована: Ноя. 18, 2021

Язык: Английский

Процитировано

44
Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward DOI Creative Commons
Jingjing Sun, Yuan Yuan,

Xiaohua Wu

и другие.

Neuron, Год журнала: 2022, Номер 110(20), С. 3356 - 3373.e8

Опубликована: Сен. 6, 2022

The use of body-focused repetitive behaviors (BFRBs) is conceptualized as a means coping with stress. However, the neurological mechanism by which affect anxiety regulation unclear. Here, we identify that excitatory somatostatin-positive neurons in medial paralemniscal nucleus (MPLSST neurons) mice promote self-grooming and encode reward. MPLSST display prominent grooming-related neuronal activity. Loss function impairs both post-stress alleviation. Activation rewarding sufficient to drive reinforcement activating dopamine (DA) ventral tegmental area (VTA) eliciting release. neuropeptide SST facilitates impact neurons. neuron-mediated triggered input from central amygdala (CeA). Our study reveals dual role CeA-MPLSST-VTADA circuit conceptualizes an interface linking stress reward systems mice.

Язык: Английский

Процитировано

38