Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila DOI Creative Commons
Michaëla Majcin Dorcikova,

Lou C. Duret,

Emma Pottié

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 22, 2023

Abstract Sleep and circadian rhythm disruptions are frequent comorbidities of Parkinson’s disease (PD), a disorder characterized by the progressive loss dopaminergic (DA) neurons in substantia nigra. However, causal role clocks degenerative process remains uncertain. We demonstrated here that regulate rhythmicity magnitude vulnerability DA to oxidative stress male Drosophila . Circadian pacemaker presynaptic subset rhythmically modulate their susceptibility degeneration. The arrhythmic period ( per ) gene null mutation exacerbates age-dependent and, combination with brief stress, causes premature animal death. These findings suggest clock disruption promotes neurodegeneration.

Язык: Английский

Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation DOI Creative Commons
Tanya Wolff, Mark Eddison, Nan Chen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

The central complex (CX) plays a key role in many higher-order functions of the insect brain including navigation and activity regulation. Genetic tools for manipulating individual cell types, knowledge what neurotransmitters neuromodulators they express, will be required to gain mechanistic understanding how these are implemented. We generated characterized split-GAL4 driver lines that express or small subsets about half CX types. surveyed neuropeptide receptor expression using fluorescent

Язык: Английский

Процитировано

6
Circadian dysregulation in Parkinson's disease DOI Creative Commons
Aleksandar Videnović, Diego A. Golombék

Neurobiology of Sleep and Circadian Rhythms, Год журнала: 2016, Номер 2, С. 53 - 58

Опубликована: Ноя. 12, 2016

Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects over one million individuals in US alone. PD characterized by a plethora of motor and non-motor manifestations, resulting from progressive degeneration dopaminergic neurons disbalance several other neurotransmitters. A growing body evidence points to significant alterations circadian system PD. This not surprising given pivotal role dopamine plays regulation as well influences metabolism. In this review we present basic clinical investigations examined function

Язык: Английский

Процитировано

56
Time-course RNASeq of Camponotus floridanus forager and nurse ant brains indicate links between plasticity in the biological clock and behavioral division of labor DOI Creative Commons
Biplabendu Das, Charissa de Bekker

BMC Genomics, Год журнала: 2022, Номер 23(1)

Опубликована: Янв. 15, 2022

Circadian clocks allow organisms to anticipate daily fluctuations in their environment by driving rhythms physiology and behavior. Inter-organismal differences rhythms, called chronotypes, exist can shift with age. In ants, age, caste-related behavior chronotype appear be linked. Brood-tending nurse ants are usually younger individuals show "around-the-clock" activity. With age or the absence of brood, nurses transition into foraging that Ants adaptively between these behavioral castes caste-associated chronotypes depending on social context. We investigated how changes gene expression could contributing such plasticity Camponotus floridanus carpenter combining time-course assays RNA-Sequencing forager brains.We found brains have three times fewer 24 h oscillating genes than foragers. However, several hundred oscillated every showed robust 8 oscillations nurses, including core clock Period Shaggy. These differentially rhythmic consisted components circadian entrainment output pathway, said involved regulating insect locomotory also Vitellogenin, known regulate division labor insects, but not Finally, we significant overlap expressed two ant ultradian expression.This study provides a first look at chronobiological brains. This endeavor allowed us identify putative molecular mechanism underlying plastic timekeeping: its seemingly oscillate different harmonics rhythm. propose has evolved for distinct regulatory networks underlie castes, while supporting swift caste transitions response colony demands. Behavioral is common among insects. The links C. floridanus, thus, likely represent more general phenomenon warrants further investigation.

Язык: Английский

Процитировано

27
Circadian programming of the ellipsoid body sleep homeostat in Drosophila DOI Creative Commons
Tomas Andreani, Clark Rosensweig,

Shiju Sisobhan

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Июнь 23, 2022

Homeostatic and circadian processes collaborate to appropriately time consolidate sleep wake. To understand how these are integrated, we scheduled brief deprivation at different times of day in

Язык: Английский

Процитировано

24
Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila DOI Creative Commons
Michaëla Majcin Dorcikova,

Lou C. Duret,

Emma Pottié

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 22, 2023

Abstract Sleep and circadian rhythm disruptions are frequent comorbidities of Parkinson’s disease (PD), a disorder characterized by the progressive loss dopaminergic (DA) neurons in substantia nigra. However, causal role clocks degenerative process remains uncertain. We demonstrated here that regulate rhythmicity magnitude vulnerability DA to oxidative stress male Drosophila . Circadian pacemaker presynaptic subset rhythmically modulate their susceptibility degeneration. The arrhythmic period ( per ) gene null mutation exacerbates age-dependent and, combination with brief stress, causes premature animal death. These findings suggest clock disruption promotes neurodegeneration.

Язык: Английский

Процитировано

14