Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 954 - 954
Опубликована: Апрель 18, 2023
Beyond
sleep/wake,
clock
genes
regulate
the
daily
rhythms
of
melatonin
production,
motor
activity,
innate
immunity,
and
mitochondrial
dynamics,
among
others.
All
these
are
affected
in
Parkinson's
disease
(PD),
suggesting
that
chronodisruption
may
be
an
early
stage
disease.
The
aim
this
study
was
to
evaluate
connection
between
PD,
whether
administration
reestablished
normal
function.
Parkinsonism
induced
with
600
μM
MPTP
(N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
24-120
h
post
fertilization
(hpf)
zebrafish
embryos
administered
at
a
dose
1
μM.
Day-night
rhythm
disappeared
MPTP-treated
embryos,
which
showed
advance
activity
phase
parallel
changes
genes.
An
alteration
fission-to-fusion
dynamics
also
detected
parkinsonian
increasing
former
leading
apoptosis.
Melatonin
fully
restored
circadian
system,
including
genes,
rhythm,
decreasing
Because
clock-controlled
such
as
sleep/wake
alterations
events
data
here
reported
point
one
initial
pathophysiological
event
Circadian
disruption
has
become
more
prevalent
in
society
due
to
the
increase
shift
work,
sleep
disruption,
blue
light
exposure,
and
travel
via
different
time
zones.
The
circadian
rhythm
is
a
timed
transcription-translation
feedback
loop
with
positive
regulators,
BMAL1
CLOCK,
that
interact
negative
CRY
PER,
regulate
both
central
peripheral
clocks.
This
review
highlights
functions
of
rhythm,
specifically
blood-brain
barrier
(BBB),
during
healthy
pathological
states.
BBB
highly
selective
dynamic
interface
composed
CNS
endothelial
cells,
astrocytes,
pericytes,
neurons,
microglia
form
neurovascular
unit
(NVU).
rhythms
modulate
integrity
through
regulating
oscillations
tight
junction
proteins,
assisting
NVU,
modulating
transporter
functions.
disruptions
within
have
been
observed
stress
responses
several
neurological
disorders,
including
brain
metastasis,
epilepsy,
Alzheimer's
disease,
Parkinson's
disease.
Further
understanding
these
interactions
may
facilitate
development
improved
treatment
options
preventative
measures.
Molecular Neurodegeneration,
Год журнала:
2022,
Номер
17(1)
Опубликована: Янв. 9, 2022
The
use
of
animals
as
models
human
physiology
is,
and
has
been
for
many
years,
an
indispensable
tool
understanding
the
mechanisms
disease.
In
Parkinson's
disease,
various
mouse
form
cornerstone
these
investigations.
Early
were
developed
to
reflect
traditional
histological
features
motor
symptoms
However,
it
is
important
that
accurately
encompass
facets
disease
allow
comprehensive
mechanistic
translational
significance.
Circadian
rhythm
sleep
issues
are
tightly
correlated
often
arise
prior
presentation
typical
deficits.
It
essential
used
understand
dysfunctions
in
circadian
rhythms
sleep,
both
facilitate
investigations
into
interplay
between
assist
development
rhythm-facing
therapeutic
treatments.
This
review
describes
extent
which
genetically-
neurotoxically-induced
murine
abnormalities
observed
clinic.
Journal of Cellular Physiology,
Год журнала:
2022,
Номер
237(8), С. 3239 - 3256
Опубликована: Июнь 13, 2022
Abstract
The
circadian
system
is
responsible
for
internal
functions
and
regulation
of
the
organism
according
to
environmental
cues
(zeitgebers).
Circadian
rhythm
dysregulation
or
chronodisruption
has
been
associated
with
several
diseases,
from
mental
autoimmune
life
quality
change.
Following
this,
some
therapies
have
developed
correct
misalignments,
such
as
light
therapy
chronobiotics.
In
this
manuscript,
we
describe
circadian‐related
diseases
so
far
investigated,
studies
reporting
relevant
data
on
topic,
evidencing
relationship,
are
included.
Despite
actual
limitations
in
published
work,
there
clear
evidence
correlation
between
disease
origin/development,
and,
way,
clock‐related
emerge
great
progress
clinical
field.
Future
improvements
interventions
can
lead
development
successful
chronotherapy
strategies,
deeply
contributing
enhanced
therapeutic
outcomes.
Frontiers in Neuroscience,
Год журнала:
2021,
Номер
14
Опубликована: Янв. 18, 2021
Disruptions
of
sleep
and
circadian
rhythms
are
among
the
most
debilitating
symptoms
in
patients
with
neurodegenerative
diseases.
Their
underlying
pathophysiology
is
multilayered
multifactorial.
Recent
evidence
suggests
that
disturbances
may
influence
processes
as
well
be
their
consequence.
In
this
perspective,
we
provide
an
update
current
understanding
dysregulation
Alzheimer’s,
Parkinson’s,
Huntington’s
Journal of Neurology,
Год журнала:
2021,
Номер
269(1), С. 125 - 148
Опубликована: Янв. 7, 2021
Abstract
Rapid
Eye
Movement
sleep
behavior
disorder
(RBD)
is
a
parasomnia
causing
sufferers
to
physically
act
out
their
dreams.
These
behaviors
can
disrupt
and
sometimes
lead
injuries
in
patients
bed-partners.
Clonazepam
melatonin
are
the
first-line
pharmacological
treatment
options
for
RBD
based
on
direct
uncontrolled
clinical
observations
very
limited
double-blind
placebo-controlled
trials.
Given
risk
adverse
outcomes,
especially
older
adults,
it
of
great
importance
assess
existing
level
evidence
use
these
treatments.
In
this
update,
we
therefore
critically
review
scientific
management
people
aged
over
50.
We
focus
treatments,
provide
an
overview
all
other
alternative
agents
trialed
could
locate
as
supplementary
materials.
By
amalgamating
observations,
our
update
shows
that
66.7%
1,026
reported
improvements
from
clonazepam
32.9%
137
various
outcome
measures
published
accounts.
Recently,
however,
three
relatively
small
randomized
trials
did
not
find
be
superior
placebo.
clinically
assumed
majorly
modify
or
eliminate
nearly
patients—there
urgent
need
test
whether
magnitude
effect
remains
intact
larger
Experimental Gerontology,
Год журнала:
2022,
Номер
172, С. 112076 - 112076
Опубликована: Дек. 24, 2022
The
circadian
system
is
an
intricate
molecular
network
of
coordinating
clocks
that
organize
the
internal
synchrony
organism
in
response
to
environment.
These
rhythms
are
maintained
by
genetically
programmed
positive
and
negative
auto-regulated
transcriptional
translational
feedback
loops
sustain
24-hour
oscillations
mRNA
protein
components
endogenous
clock.
Since
inter
intracellular
activity
central
pacemaker
appears
reduce
with
aging,
interaction
between
clock
aging
continues
elude
our
understanding.
In
this
review
article,
we
discuss
at
level
how
adversely
affects
functioning
rodents
humans.
natural
decline
melatonin
levels
strongly
contributes
dysregulation
resulting
development
neurological
anomalies.
Additionally,
inappropriate
environmental
conditions
such
as
Artificial
Light
Night
(ALAN)
can
cause
disruption
or
chronodisruption
(CD)
which
result
a
variety
pathological
diseases,
including
premature
aging.
Furthermore,
summarize
recent
evidence
suggesting
CD
may
also
be
predisposing
factor
for
age-related
neurodegenerative
diseases
(NDDs)
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
although
more
investigation
required
prove
link.
Finally,
certain
chrono-enhancement
approaches
have
been
offered
intervention
strategies
prevent,
alleviate,
mitigate
impacts
CD.
This
thus
aims
bring
together
advancements
chronobiology
process,
well
its
role
NDDs.
