International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(13), С. 7227 - 7227
Опубликована: Июль 5, 2021
Atopic
dermatitis
(AD)
is
a
prototypic
inflammatory
disease
that
presents
with
intense
itching.
The
pathophysiology
of
AD
multifactorial,
involving
environmental
factors,
genetic
susceptibility,
skin
barrier
function,
and
immune
responses.
A
recent
understanding
pruritus
transmission
provides
more
information
about
the
role
pruritogens
in
pathogenesis
AD.
There
evidence
are
not
only
responsible
for
eliciting
pruritus,
but
also
interact
cells
act
as
mediators,
which
exacerbate
severity
In
this
review,
we
discuss
interaction
between
molecules
summarize
targeted
therapies
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Июнь 16, 2020
Abstract
Itch,
in
particular
chronic
forms,
has
been
widely
recognized
as
an
important
clinical
problem,
but
much
less
is
known
about
the
mechanisms
of
itch
comparison
with
other
sensory
modalities
such
pain.
Recently,
considerable
progress
made
dissecting
circuit
at
both
spinal
and
supraspinal
levels.
Major
components
neural
underlying
chemical
mechanical
have
now
identified,
along
circuits
relaying
ascending
transmission
descending
modulation
itch.
In
this
review,
we
summarize
elucidating
mechanism
Journal of Neural Transmission,
Год журнала:
2020,
Номер
127(4), С. 505 - 525
Опубликована: Апрель 1, 2020
Abstract
The
dorsal
horns
of
the
spinal
cord
and
trigeminal
nuclei
in
brainstem
contain
neuron
populations
that
are
critical
to
process
sensory
information.
Neurons
these
areas
highly
heterogeneous
their
morphology,
molecular
phenotype
intrinsic
properties,
making
it
difficult
identify
functionally
distinct
cell
populations,
determine
how
engaged
pathophysiological
conditions.
There
is
a
growing
consensus
concerning
classification
based
on
transcriptomic
transductomic
analyses
horn.
These
approaches
have
led
discovery
several
molecularly
defined
types
been
implicated
cutaneous
mechanical
allodynia,
prevalent
difficult-to-treat
symptom
chronic
pain,
which
touch
becomes
painful.
main
objective
this
review
provide
contemporary
view
horn
neuronal
describe
recent
advances
our
understanding
they
participate
allodynia.
Annual Review of Neuroscience,
Год журнала:
2020,
Номер
43(1), С. 187 - 205
Опубликована: Фев. 20, 2020
Itch
is
a
unique
sensation
that
helps
organisms
scratch
away
external
threats;
scratching
itself
induces
an
immune
response
can
contribute
to
more
itchiness.
induced
chemically
in
the
peripheral
nervous
system
via
wide
array
of
receptors.
Given
superficial
localization
itch
neuron
terminals,
cells
dwell
close
skin
significantly
itch.
Certain
mechanical
stimuli
mediated
by
recently
discovered
circuits
also
sensation.
Ultimately,
spinal
cord,
and
likely
brain,
mediate
touch,
pain,
engage
cross
modulation.
Much
perception
still
mystery,
but
we
present
this
review
known
ligands
receptors
associated
with
We
describe
experiments
findings
from
investigations
into
supraspinal
circuitry
responsible
for
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Март 13, 2020
Abstract
Gastrin-releasing
peptide
(GRP)
functions
as
a
neurotransmitter
for
non-histaminergic
itch,
but
its
site
of
action
(sensory
neurons
vs
spinal
cord)
remains
controversial.
To
determine
the
role
GRP
in
sensory
neurons,
we
generated
floxed
Grp
mouse
line.
We
found
that
conditional
knockout
results
attenuated
without
impairing
histamine-induced
itch.
Using
-Cre
knock-in
line,
show
upper
epidermis
skin
is
exclusively
innervated
by
fibers,
whose
activation
via
optogeneics
and
chemogenetics
evokes
itch-
not
pain-related
scratching
or
wiping
behaviors.
In
contrast,
intersectional
genetic
ablation
does
affect
itch
nor
pain
transmission,
demonstrating
are
dispensable
transmission.
These
data
indicate
neuropeptide
dedicated
to
The
neuropeptides
Substance
P
and
CGRPα
have
long
been
thought
important
for
pain
sensation.
Both
peptides
their
receptors
are
expressed
at
high
levels
in
pain-responsive
neurons
from
the
periphery
to
brain
making
them
attractive
therapeutic
targets.
However,
drugs
targeting
these
pathways
individually
did
not
relieve
clinical
trials.
Since
extensively
co-expressed,
we
hypothesized
that
simultaneous
inhibition
would
be
required
effective
analgesia.
We
therefore
generated
Tac1
Calca
double
knockout
(DKO)
mice
assessed
behavior
using
a
wide
range
of
pain-relevant
assays.
As
expected,
were
undetectable
throughout
nervous
system
DKO
mice.
To
our
surprise,
animals
displayed
largely
intact
responses
mechanical,
thermal,
chemical,
visceral
stimuli,
as
well
itch.
Moreover,
chronic
inflammatory
neurogenic
inflammation
unaffected
by
loss
two
peptides.
Finally,
neuropathic
evoked
nerve
injury
or
chemotherapy
treatment
was
also
preserved
peptide-deficient
Thus,
results
demonstrate
even
combination,
transmission
acute
pain.
Theranostics,
Год журнала:
2020,
Номер
10(26), С. 12111 - 12126
Опубликована: Янв. 1, 2020
Psoriasis
is
a
chronic
inflammatory
disease
caused
by
complex
interplay
between
the
immune
and
nervous
systems
with
recurrent
scaly
skin
plaques,
thickened
stratum
corneum,
infiltration
activation
of
cells,
itch.
Despite
an
increasing
availability
therapies,
they
often
have
adverse
effects,
high
costs,
dissociated
effects
on
inflammation
Activation
sensory
neurons
innervating
TRPV1
(transient
receptor
potential
vanilloid
1)
are
emerging
as
critical
components
in
pathogenesis
psoriasis,
but
little
known
about
their
endogenous
inhibitors.
Recent
studies
demonstrated
that
resolvins,
lipid
mediators
derived
from
omega-3
fatty
acids,
potent
inhibitors
TRP
channels
may
offer
new
therapies
for
psoriasis
without
effects.
