Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains

eLife, Год журнала: 2020, Номер 9

Опубликована: Июнь 16, 2020

Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems activated during such decisions. In previous work in humans, we found that evoked responses of decisions reported rapid dilations the pupil and track a suppression biases accumulation decision-relevant (de Gee et al., 2017). Here, show this arousal-related decision bias acts on both conservative liberal biases, generalizes from humans to mice, perceptual memory-based challenging sound-detection tasks, impact spontaneous or experimentally induced choice was reduced under high phasic arousal. Similar occurred when drawn memory. All these behavioral effects were explained biases. Our results point general principle interplay between decision-making.

Язык: Английский

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Task-evoked activity quenches neural correlations and variability across cortical areas

PLoS Computational Biology, Год журнала: 2020, Номер 16(8), С. e1007983 - e1007983

Опубликована: Авг. 3, 2020

Many large-scale functional connectivity studies have emphasized the importance of communication through increased inter-region correlations during task states. In contrast, local circuit demonstrated that states primarily reduce among pairs neurons, likely enhancing their information coding by suppressing shared spontaneous activity. Here we sought to adjudicate between these conflicting perspectives, assessing whether co-active brain regions tend increase or decrease correlations. We found variability and across a variety cortical in two highly distinct data sets: non-human primate spiking human magnetic resonance imaging data. Moreover, this observed correlation reduction was accompanied an overall dimensionality (reflecting less redundancy) states, suggesting decreased capacity. further both neural mass computational models task-evoked activity stability around stable attractor, globally quenching Together, our results provide integrative mechanistic account encompasses measures activity, variability, resting

Язык: Английский

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Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice

Nature Methods, Год журнала: 2021, Номер 18(4), С. 417 - 425

Опубликована: Апрель 1, 2021

Язык: Английский

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Principles of Corticocortical Communication: Proposed Schemes and Design Considerations

Trends in Neurosciences, Год журнала: 2020, Номер 43(9), С. 725 - 737

Опубликована: Авг. 5, 2020

Язык: Английский

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Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

Cell, Год журнала: 2020, Номер 184(2), С. 489 - 506.e26

Опубликована: Дек. 17, 2020

Язык: Английский

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A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

Neuron, Год журнала: 2021, Номер 109(21), С. 3500 - 3520.e13

Опубликована: Сен. 17, 2021

Dopamine is required for working memory, but how it modulates the large-scale cortex unknown. Here, we report that dopamine receptor density per neuron, measured by autoradiography, displays a macroscopic gradient along macaque cortical hierarchy. This incorporated in connectome-based model endowed with multiple neuron types. The captures an inverted U-shaped dependence of memory on and spatial patterns persistent activity observed over 90 experimental studies. Moreover, show crucial filtering out irrelevant stimuli enhancing inhibition from dendrite-targeting interneurons. Our revealed activity-silent trace can be realized facilitation inter-areal connections adjusting induces switch this internal state to distributed activity. work represents cross-level understanding molecules cell types recurrent circuit dynamics underlying core cognitive function across primate cortex.

Язык: Английский

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Cortical Observation by Synchronous Multifocal Optical Sampling Reveals Widespread Population Encoding of Actions

Neuron, Год журнала: 2020, Номер 107(2), С. 351 - 367.e19

Опубликована: Май 19, 2020

Язык: Английский

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A goal-driven modular neural network predicts parietofrontal neural dynamics during grasping

Proceedings of the National Academy of Sciences, Год журнала: 2020, Номер 117(50), С. 32124 - 32135

Опубликована: Ноя. 30, 2020

Significance Grasping objects is something primates do effortlessly, but how does our brain coordinate such a complex task? Multiple areas across the parietal and frontal cortices of macaque monkeys are essential for shaping hand during grasping, we lack comprehensive model grasping from vision to action. In this work, show that multiarea neural networks trained reproduce arm control required using visual features also reproduced dynamics in regions relationships between areas, outperforming alternative models. Simulated lesion experiments revealed unique deficits paralleling lesions specific circuit, providing these work together drive behavior.

Язык: Английский

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Sensory coding and the causal impact of mouse cortex in a visual decision

eLife, Год журнала: 2021, Номер 10

Опубликована: Июль 30, 2021

Correlates of sensory stimuli and motor actions are found in multiple cortical areas, but such correlates do not indicate whether these areas causally relevant to task performance. We trained mice discriminate visual contrast report their decision by steering a wheel. Widefield calcium imaging Neuropixels recordings cortex revealed stimulus-related activity (VIS) frontal (MOs) widespread movement-related across the whole dorsal cortex. Optogenetic inactivation biased choices only when targeted at VIS MOs,proportionally each site's encoding stimulus, times corresponding peak stimulus decoding. A neurometric model based on summing subtracting MOs successfully described behavioral performance predicted effect optogenetic inactivation. Thus, signals localized play causal role performance, while correlating with movement reflect processes that role.

Язык: Английский

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Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging

Journal of Neuroscience, Год журнала: 2021, Номер 41(19), С. 4160 - 4168

Опубликована: Апрель 23, 2021

The brain functions through coordinated activity among distributed regions. Wide-field calcium imaging, combined with improved genetically encoded indicators, allows sufficient signal-to-noise ratio and spatiotemporal resolution to afford a unique opportunity capture cortex-wide dynamics on moment-by-moment basis in behaving animals. Recent applications of this approach have been uncovering cortical at unprecedented scales during various cognitive processes, ranging from relatively simple sensorimotor integration more complex decision-making tasks. In review, we will highlight recent scientific advances enabled by wide-field imaging mice. We then summarize several technical considerations future opportunities for uncover large-scale circuit dynamics.

Язык: Английский

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