The cerebellum and psychological trauma: A systematic review of neuroimaging studies

Neurobiology of Stress, Год журнала: 2022, Номер 17, С. 100429 - 100429

Опубликована: Янв. 14, 2022

Psychological trauma is highly prevalent among psychiatric disorders, however, the relationship between trauma, neurobiology and psychopathology not yet fully understood. The cerebellum has been recognized as a crucial structure for cognition emotion, it relatively ignored in literature of psychological considered part traditional fear neuro-circuitry. aim this review to investigate how affects make conclusive remarks on whether forms trauma-affected brain circuitry. A total 267 unique records were screened 39 studies included review. Structural cerebellar alterations aberrant activity connectivity trauma-exposed individuals consistently reported across studies. Early-onset adverse experiences was associated with individuals. Several nodes large-brain networks, which are implicated several including default mode network, salience network central executive network. Also, showed altered resting state task based cortical subcortical structures that involved emotion regulation. Our preferred interpretation results through lens Universal Cerebellar Transform, hypothesis cerebellum, given its homogeneous cytoarchitecture, performs common computation motor, cognitive emotional functions. Therefore, trauma-induced might set ground variety symptoms.

Язык: Английский

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Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control

Nature Neuroscience, Год журнала: 2023, Номер 26(8), С. 1394 - 1406

Опубликована: Июль 20, 2023

The brain generates predictive motor commands to control the spatiotemporal precision of high-velocity movements. Yet, how organizes automated internal feedback coordinate kinematics such fast movements is unclear. Here we unveil a unique nucleo-olivary loop in cerebellum and its involvement coordinating Activating excitatory pathway induces well-timed complex spike signals Purkinje cells shape cerebellar outputs. Anatomical tracing reveals extensive axonal collaterals from neurons downstream regions, supporting integration output within cerebellum. This directly drives saccades head with converging direction, while curtailing their amplitude velocity via powerful mechanism. Our finding challenges long-standing dogma that inhibits inferior olivary provides new circuit mechanism for

Язык: Английский

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The Rules of Cerebellar Learning: Around the Ito Hypothesis

Neuroscience, Год журнала: 2020, Номер 462, С. 175 - 190

Опубликована: Авг. 29, 2020

Язык: Английский

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The relationship between birth timing, circuit wiring, and physiological response properties of cerebellar granule cells

Proceedings of the National Academy of Sciences, Год журнала: 2021, Номер 118(23)

Опубликована: Июнь 4, 2021

Cerebellar granule cells (GrCs) are usually regarded as a uniform cell type that collectively expands the coding space of cerebellum by integrating diverse combinations mossy fiber inputs. Accordingly, stable molecularly or physiologically defined GrC subtypes within single cerebellar region have not been reported. The only known cellular property distinguishes otherwise homogeneous GrCs is correspondence between birth timing and depth molecular layer to which their axons project. To determine role plays in wiring function, we developed genetic strategies access early- late-born GrCs. We initiated retrograde monosynaptic rabies virus tracing from control (birth unrestricted), early-born, GrCs, revealing different patterns input vermis lobule 6 simplex, well 6: sensory motor nuclei provide more early-born while basal pontine In vivo multidepth two-photon Ca

Язык: Английский

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Cortico-cerebellar interactions during goal-directed behavior

Current Opinion in Neurobiology, Год журнала: 2020, Номер 65, С. 27 - 37

Опубликована: Сен. 24, 2020

Язык: Английский

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