Oxytocin, Neural Plasticity, and Social Behavior

Annual Review of Neuroscience, Год журнала: 2021, Номер 44(1), С. 359 - 381

Опубликована: Апрель 7, 2021

Oxytocin regulates parturition, lactation, parental nurturing, and many other social behaviors in both sexes. The circuit mechanisms by which oxytocin modulates behavior are receiving increasing attention. Here, we review recent studies on modulation of neural function behavior, largely enabled new methods monitoring manipulating or receptor neurons vivo. These indicate that can enhance the salience stimuli increase signal-to-noise ratios modulating spiking synaptic plasticity context circuits networks. We highlight effects nontraditional organisms such as prairie voles discuss opportunities to utility these for studying circuit-level behaviors. then insights into neuron activity during interactions. conclude discussing some major questions field ahead.

Язык: Английский

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What is the dynamical regime of cerebral cortex?

Neuron, Год журнала: 2021, Номер 109(21), С. 3373 - 3391

Опубликована: Авг. 30, 2021

Язык: Английский

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Where is the error? Hierarchical predictive coding through dendritic error computation

Trends in Neurosciences, Год журнала: 2022, Номер 46(1), С. 45 - 59

Опубликована: Ноя. 18, 2022

Top-down feedback in cortex is critical for guiding sensory processing, which has prominently been formalized the theory of hierarchical predictive coding (hPC). However, experimental evidence error units, are central to theory, inconclusive and it remains unclear how hPC can be implemented with spiking neurons. To address this, we connect existing work on efficient balanced networks lateral inhibition computation at apical dendrites. Together, this points an implementation neurons, where prediction errors computed not separate but locally dendritic compartments. We then discuss correspondence model experimentally observed connectivity patterns, plasticity, dynamics cortex.

Язык: Английский

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Regulation of circuit organization and function through inhibitory synaptic plasticity

Trends in Neurosciences, Год журнала: 2022, Номер 45(12), С. 884 - 898

Опубликована: Окт. 28, 2022

Язык: Английский

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The plasticitome of cortical interneurons

Nature reviews. Neuroscience, Год журнала: 2022, Номер 24(2), С. 80 - 97

Опубликована: Дек. 30, 2022

Язык: Английский

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The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms

Frontiers in Synaptic Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Май 19, 2022

Synaptic plasticity is a critical process that regulates neuronal activity by allowing neurons to adjust their synaptic strength in response changes activity. Despite the high proximity of excitatory glutamatergic and inhibitory GABAergic postsynaptic zones functional integration within dendritic regions, concurrent has historically been underassessed. Growing evidence for pathological disruptions excitation inhibition (E/I) balance neurological neurodevelopmental disorders indicates need an improved, more "holistic" understanding interplay. There continues be long-standing focus on persistent strengthening (excitatory long-term potentiation; eLTP) its role learning memory, although importance potentiation (iLTP) depression (iLTD) become increasingly apparent. Emerging further points dynamic dialogue between synapses, but much remains understood regarding mechanisms extent this exchange. In mini-review, we explore calcium signaling crosstalk play regulating excitability. We examine current knowledge synapse responses perturbances activity, with induced short-term pharmacological treatments which act either enhance or reduce excitability via ionotropic receptor regulation culture. To delve deeper into potential crosstalk, discuss influence key regulatory proteins, including kinases, phosphatases, structural/scaffolding proteins. Finally, briefly suggest avenues future research better understand synapses.

Язык: Английский

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The generation of cortical novelty responses through inhibitory plasticity

eLife, Год журнала: 2021, Номер 10

Опубликована: Окт. 14, 2021

Animals depend on fast and reliable detection of novel stimuli in their environment. Neurons multiple sensory areas respond more strongly to comparison familiar stimuli. Yet, it remains unclear which circuit, cellular, synaptic mechanisms underlie those responses. Here, we show that spike-timing-dependent plasticity inhibitory-to-excitatory synapses generates novelty responses a recurrent spiking network model. Inhibitory increases the inhibition onto excitatory neurons tuned stimuli, while for low, leading response. The generation does not periodicity but rather distribution presented By including tuning inhibitory neurons, further captures stimulus-specific adaptation. Finally, suggest disinhibition can control amplification Therefore, provides flexible, biologically plausible mechanism detect bottom-up enabling us make experimentally testable predictions.

Язык: Английский

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Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity

Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Янв. 3, 2022

Throughout early phases of brain development, the two main neural signaling mechanisms-excitation and inhibition-are dynamically sculpted in neocortex to establish primary functions. Despite its relatively late formation persistent developmental changes, GABAergic system promotes ordered shaping neuronal circuits at structural functional levels. Within this frame, interneurons participate first spontaneous later sensory-evoked activity patterns that precede cortical functions mature brain. Upon their subcortical generation, embryonic must orderly migrate settle respective target layers before they can actively engage network activity. During process, changes molecular synaptic level allow not only coordinated but also pruning connections as well excitatory inhibitory synapses. At postsynaptic site, shift from an towards response is required enable synchronization within networks. Concomitantly, progressive specification different interneuron subtypes endows with distinct local region-specific modulation firing. Finally, apoptotic process further refines populations by constantly maintaining a controlled ratio neurons. Interestingly, many these fundamental complex processes are influenced-if directly controlled-by electrical Interneurons on subcellular, cellular, affected high frequency patterns, such spindle burst gamma oscillations rodents delta brushes humans. Conversely, maturation structure function each scales feeds back contributes generation essential for proper peri- postnatal development. Overall, more precise description conducting role terms how contribute specific patterns-as impinge orchestra members-will lead better understanding physiological pathophysiological development nervous system.

Язык: Английский

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Spatial regulation of coordinated excitatory and inhibitory synaptic plasticity at dendritic synapses

Cell Reports, Год журнала: 2022, Номер 38(6), С. 110347 - 110347

Опубликована: Фев. 1, 2022

The induction of synaptic plasticity at an individual dendritic glutamatergic spine can affect neighboring spines. This local modulation generates microdomains believed to expand the neuronal computational capacity. Here, we investigate whether also occur between synapses and adjacent GABAergic synapses. We find that long-term potentiation causes depression nearby inhibitory (within 3 μm), whereas more distant ones are potentiated. Notably, L-type calcium channels calpain required for this spreading. Overall, our data support a model whereby input-specific postsynaptic induces spatially regulated rearrangement strength in surrounding area through short-range heterosynaptic interactions. Such coordination excitatory is expected influence information processing integration.

Язык: Английский

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My Neighbour Hetero — deconstructing the mechanisms underlying heterosynaptic plasticity

Current Opinion in Neurobiology, Год журнала: 2020, Номер 67, С. 106 - 114

Опубликована: Ноя. 5, 2020

Язык: Английский

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