MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway

Journal of Investigative Dermatology, Год журнала: 2020, Номер 141(5), С. 1286 - 1296.e4

Опубликована: Окт. 13, 2020

Язык: Английский

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Glutamate in primary afferents is required for itch transmission

Neuron, Год журнала: 2022, Номер 110(5), С. 809 - 823.e5

Опубликована: Янв. 4, 2022

Язык: Английский

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Neuroimmune interactions in atopic and allergic contact dermatitis

Journal of Allergy and Clinical Immunology, Год журнала: 2023, Номер 151(5), С. 1169 - 1177

Опубликована: Май 1, 2023

Язык: Английский

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Reproducible and fully automated testing of nocifensive behavior in mice

Cell Reports Methods, Год журнала: 2023, Номер 3(12), С. 100650 - 100650

Опубликована: Дек. 1, 2023

Язык: Английский

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Educational and psychological interventions for managing atopic dermatitis (eczema)

Cochrane library, Год журнала: 2024, Номер 2024(8)

Опубликована: Авг. 12, 2024

Язык: Английский

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Mrgprd Cre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit

Pain, Год журнала: 2021, Номер 162(7), С. 2120 - 2131

Опубликована: Фев. 4, 2021

Abstract Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors respond noxious input in a graded manner. However, mechanically sensitive, fibers also mechanical the innocuous range, so degree which they contribute nociception remains unclear. To address this gap, we investigated function of afferents using Mrgprd Cre allele. In real-time place aversion studies, found that low-frequency optogenetic activation Mrgrpd lineage neurons was not aversive naive mice but became after spared nerve injury (SNI). underlying mechanisms allodynia, recorded responses from lamina I spinoparabrachial (SPB) semi-intact ex vivo preparation. After SNI, brushing skin gave rise abnormal activity SPB neurons, consisting an increase proportion responded with excitatory postsynaptic potentials or action potentials. This likely due, at least part, received on neurons. Intriguingly, there significant current latency consistent possibility greater post-SNI could due recruitment new polysynaptic circuit. Together, our findings suggest can provide dorsal horn is nonnoxious before becomes afterwards because engagement previously silent circuit horn.

Язык: Английский

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Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action

Journal of Pain, Год журнала: 2021, Номер 23(2), С. 196 - 211

Опубликована: Авг. 20, 2021

Язык: Английский

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Association between P2X3 receptors and neuropathic pain: As a potential therapeutic target for therapy

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 113029 - 113029

Опубликована: Апрель 27, 2022

Neuropathic pain is a common clinical symptom of various diseases, and it seriously affects the physical mental health patients. Owing to complex pathological mechanism neuropathic pain, treatment challenging. Therefore, there growing interest among researchers explore potential therapeutic strategies for pain. A large number studies have shown that development related nerve conduction signaling molecules. P2X3 receptors (P2X3R) are ATP-dependent ion channels participate in transmission neural information pathways, sensitize central nervous system, play key role In this paper, we summarized structure biological characteristics P2X3R gene discussed system. Moreover, outlined mechanisms described relationship between chronic provide valuable novel

Язык: Английский

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Transcriptional Alterations of Mouse Trigeminal Ganglion Neurons Following Orofacial Inflammation Revealed by Single-Cell Analysis

Frontiers in Cellular Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Июнь 2, 2022

Orofacial inflammation leads to transcriptional alterations in trigeminal ganglion (TG) neurons. However, diverse and regulatory mechanisms following orofacial inflammatory pain different types of TG neurons remain unclear. Here, was induced by injection complete Freund’s adjuvant (CFA) mice. After 7 days, we performed single-cell RNA-sequencing on cells mice from control treatment groups. We identified primary sensory neurons, Schwann cells, satellite glial oligodendrocyte-like immune fibroblasts, endothelial tissue. principal component analysis hierarchical clustering, six neuronal subpopulations: peptidergic nociceptors (PEP1 PEP2), non-peptidergic (NP1 NP2), C-fiber low-threshold mechanoreceptors (cLTMR) myelinated ( Nefh -positive NF) based annotated marker gene expression. also differential expression among subtypes, identifying several genes involved the response, excitability, neuroprotection, metabolic processes. Notably, potential novel targets associated with modulation, including Arl6ip1 , Gsk3b Scn7a Zbtb20 PEP1, Rgs7bp PEP2, Bhlha9 cLTMR. The established protein–protein interaction network some hub genes, implying their critical involvement regulating pain. Our study revealed heterogeneity transcriptomic responses inflammation, providing a basis for development therapeutic strategies

Язык: Английский

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Potential mechanisms of acupuncture for neuropathic pain based on somatosensory system

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Сен. 20, 2022

Neuropathic pain, caused by a lesion or disease of the somatosensory system, is common and distressing. In view high human economic burden, more effective treatment strategies were urgently needed. Acupuncture has been increasingly used as an adjuvant complementary therapy for neuropathic pain. Although therapeutic effects acupuncture have demonstrated in various high-quality randomized controlled trials, there significant heterogeneity underlying mechanisms. This review aimed to summarize potential mechanisms on pain based guided future both foundational clinical studies. Here, we argued that may inhibit neuronal activity through reducing activation pain-related ion channels suppressing glial cells (including microglia astrocytes) release inflammatory cytokines, chemokines, amongst others. Meanwhile, non-pharmacologic treatment, activate descending control system via increasing level spinal brain 5-hydroxytryptamine (5-HT), norepinephrine (NE), opioid peptides. And types endogenously peptides was influenced electroacupuncture-frequency. The cumulative evidence provided alternative adjunctive

Язык: Английский

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