Current Opinion in Behavioral Sciences,
Год журнала:
2024,
Номер
57, С. 101391 - 101391
Опубликована: Апрель 17, 2024
Animal
brains
are
probably
the
most
complex
computational
machines
on
our
planet,
and
like
everything
in
biology,
they
product
of
evolution.
Advances
developmental
palaeobiology
have
been
expanding
general
understanding
how
nervous
systems
can
change
at
a
molecular
structural
level.
However,
these
changes
translate
into
altered
function
—
that
is,
'computation'
remains
comparatively
sparsely
explored.
What,
concretely,
does
it
mean
for
neuronal
computation
when
neurons
their
morphology
connectivity,
new
appear
or
old
ones
disappear,
transmitter
slowly
modified
over
many
generations?
And
evolution
use
possible
knobs
dials
to
constantly
tune
give
rise
amazing
diversity
animal
behaviours
we
see
today?
Addressing
major
gaps
benefits
from
choosing
suitable
model
system.
Here,
I
present
vertebrate
retina
as
one
perhaps
unusually
promising
candidate.
The
is
ancient
displays
highly
conserved
core
organisational
principles
across
entire
lineage,
alongside
myriad
adjustments
extant
species
were
shaped
by
history
visual
ecology.
Moreover,
logic
readily
interrogated
experimentally,
existing
retinal
circuits
handful
serve
an
anchor
exploring
circuit
adaptations
tree
life,
fish
deep
aphotic
zone
oceans
eagles
soaring
high
up
sky.
Biomolecules,
Год журнала:
2021,
Номер
11(1), С. 78 - 78
Опубликована: Янв. 9, 2021
Zebrafish
are
an
instrumental
system
for
the
generation
of
photoreceptor
degeneration
models,
which
can
be
utilized
to
determine
underlying
causes
dysfunction
and
death,
analysis
potential
therapeutic
compounds,
as
well
characterization
regenerative
responses.
We
review
wealth
information
from
existing
zebrafish
models
disease,
specifically
they
relate
currently
accepted
taxonomic
classes
human
rod
cone
disease.
also
highlight
that
rich,
detailed
derived
studying
development,
structure,
function,
including
behavioural
assessments
in
vivo
imaging
zebrafish.
available
a
diversity
diseases,
dystrophies,
challenging
recapitulate
nocturnal
mammalian
systems.
Newly
discovered
disease
drusenoid
deposit
formation
may
not
only
provide
important
insights
into
pathogenesis
but
approaches.
have
already
shown
their
use
providing
pre-clinical
data
prior
testing
genetic
therapies
clinical
trials,
such
antisense
oligonucleotide
therapy
Usher
syndrome.
During
development,
retinal
progenitors
navigate
a
complex
landscape
of
fate
decisions
to
generate
the
major
cell
classes
necessary
for
proper
vision.
Transcriptional
regulation
is
critical
diversity
within
these
classes.
Here,
we
aim
provide
resources
and
techniques
required
identify
transcription
factors
maintain
in
photoreceptor
subtypes,
which
are
First,
key
resource:
high-quality
deep
transcriptomic
profile
each
subtype
adult
zebrafish.
We
make
this
resource
openly
accessible,
easy
explore,
have
integrated
it
with
other
currently
available
datasets.
Second,
using
our
profiles,
derive
an
in-depth
map
expression
photoreceptors.
Third,
use
efficient
CRISPR-Cas9
based
mutagenesis
screen
null
phenotypes
F0
larvae
(F0
screening)
as
fast,
efficient,
versatile
technique
assess
involvement
candidate
generation
subtypes.
first
show
that
known
can
be
easily
replicated
method:
loss
S
cones
foxq2
mutants
rods
nr2e3
mutants.
then
novel
functions
factor
Tbx2,
demonstrating
plays
distinct
roles
controlling
all
subtypes
retina.
Our
study
provides
roadmap
discover
additional
involved
process.
Additionally,
explore
four
unknown
function
(Skor1a,
Sall1a,
Lrrfip1a,
Xbp1),
find
no
evidence
their
This
dataset
screening
method
will
valuable
way
genes
many
essential
aspects
biology.
Current Opinion in Behavioral Sciences,
Год журнала:
2024,
Номер
57, С. 101391 - 101391
Опубликована: Апрель 17, 2024
Animal
brains
are
probably
the
most
complex
computational
machines
on
our
planet,
and
like
everything
in
biology,
they
product
of
evolution.
Advances
developmental
palaeobiology
have
been
expanding
general
understanding
how
nervous
systems
can
change
at
a
molecular
structural
level.
However,
these
changes
translate
into
altered
function
—
that
is,
'computation'
remains
comparatively
sparsely
explored.
What,
concretely,
does
it
mean
for
neuronal
computation
when
neurons
their
morphology
connectivity,
new
appear
or
old
ones
disappear,
transmitter
slowly
modified
over
many
generations?
And
evolution
use
possible
knobs
dials
to
constantly
tune
give
rise
amazing
diversity
animal
behaviours
we
see
today?
Addressing
major
gaps
benefits
from
choosing
suitable
model
system.
Here,
I
present
vertebrate
retina
as
one
perhaps
unusually
promising
candidate.
The
is
ancient
displays
highly
conserved
core
organisational
principles
across
entire
lineage,
alongside
myriad
adjustments
extant
species
were
shaped
by
history
visual
ecology.
Moreover,
logic
readily
interrogated
experimentally,
existing
retinal
circuits
handful
serve
an
anchor
exploring
circuit
adaptations
tree
life,
fish
deep
aphotic
zone
oceans
eagles
soaring
high
up
sky.
