Distributed chromatic processing at the interface between retina and brain in the larval zebrafish DOI Creative Commons
Drago Guggiana-Nilo,

Clemens Riegler,

Mark Hübener

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(9), P. 1945 - 1953.e5

Published: Feb. 26, 2021

Larval zebrafish (Danio rerio) are an ideal organism for studying color vision, as their retina possesses four types of cone photoreceptors, covering most the visible range and into UV.1Raymond P.A. Barthel L.K. Curran G.A. Developmental patterning rod photoreceptors in embryonic zebrafish.J. Comp. Neurol. 1995; 359: 537-550Crossref PubMed Scopus (254) Google Scholar,2Robinson J. Schmitt E.A. Hárosi F.I. Reece R.J. Dowling J.E. Zebrafish ultraviolet visual pigment: absorption spectrum, sequence, localization.Proc. Natl. Acad. Sci. USA. 1993; 90: 6009-6012Crossref (191) Scholar Additionally, eye nervous systems accessible to imaging, given that they naturally transparent.3Spence R. Gerlach G. Lawrence C. Smith The behaviour ecology zebrafish, Danio rerio.Biol. Rev. Camb. Philos. Soc. 2008; 83: 13-34Crossref (627) Scholar, 4Portugues Feierstein C.E. Engert F. Orger M.B. Whole-brain activity maps reveal stereotyped, distributed networks visuomotor behavior.Neuron. 2014; 81: 1328-1343Abstract Full Text PDF (163) 5Ahrens Robson D.N. Li J.M. Keller P.J. functional imaging at cellular resolution using light-sheet microscopy.Nat. Methods. 2013; 10: 413-420Crossref (737) Recent studies have found that, through a set wavelength-range-specific horizontal, bipolar, retinal ganglion cells (RGCs),6Zimmermann M.J.Y. Nevala N.E. Yoshimatsu T. Osorio D. Nilsson D.-E. Berens P. Baden differentially process across space match natural scenes.Curr. Biol. 2018; 28: 2018-2032.e5Abstract (63) 7Connaughton V.P. Nelson Spectral responses horizontal include tetraphasic response novel UV-dominated triphasic response.J. Neurophysiol. 2010; 104: 2407-2422Crossref (34) 8Zhou M. Bear Roberts Janiak F.K. Semmelhack asymmetrically encode spectral temporal information space.Curr. 2020; 30: 2927-2942.e7Abstract (10) 9Yoshimatsu Schröder Fovea-like photoreceptor specializations underlie single UV driven prey-capture behavior zebrafish.Neuron. 107: 320-337.e6Abstract (22) relays tetrachromatic several retinorecipient areas (RAs).10Ma Kler S. Pan Y.A. Structural neural connectivity analysis with restricted anterograde transneuronal viral labeling quantitative brain mapping.Front. Neural Circuits. 13: 85Crossref (5) 11Wulliman M.F. Rupp B. Reichert H. Neuroanatomy Brain: A Topological Atlas. Birkhäuser, 2012Google 12Bartel Colourfulness possible measure object proximity larval brain.bioRxiv. https://doi.org/10.1101/2020.12.03.410241Crossref (0) 13Fornetto Tiso N. Pavone F.S. Vanzi Colored stimuli evoke spectrally tuned neuronal central system larvae.BMC 18: 172Crossref (6) main RA is optic tectum, receiving 97% RGC axons via neuropil mass termed arborization field 10 (AF10).14Robles E. Laurell Baier projectome reveals brain-area-specific representations generated by cell diversity.Curr. 24: 2085-2096Abstract (84) Scholar,15Burrill J.D. Easter Jr., S.S. Development retinofugal projections (Brachydanio rerio).J. 1994; 346: 583-600Crossref (182) Here, we aim understand processing chromatic signals interface between RGCs major targets. We used 2-photon calcium separately neurons different awake animals. find widespread throughout brain, large variety among RGCs, even greater diversity Specific combinations enriched specific nuclei, but there no structure. In this pathway, connection AF10 observe key elements processing, such enhanced signal decorrelation improved decoding.16Niessing Friedrich R.W. Olfactory pattern classification discrete network states.Nature. 465: 47-52Crossref (124) Scholar,17Johnson K.O. coding.Neuron. 2000; 26: 563-566Abstract (26) richer stimulus revealed these enhancements occur context more code facilitating association small vertebrate brain.

Language: Английский

Transcription factors underlying photoreceptor diversity DOI Creative Commons
Juan M Angueyra, Vincent P Kunze,

Laura K Patak

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Feb. 6, 2023

During development, retinal progenitors navigate a complex landscape of fate decisions to generate the major cell classes necessary for proper vision. Transcriptional regulation is critical diversity within these classes. Here, we aim provide resources and techniques required identify transcription factors maintain in photoreceptor subtypes, which are First, key resource: high-quality deep transcriptomic profile each subtype adult zebrafish. We make this resource openly accessible, easy explore, have integrated it with other currently available datasets. Second, using our profiles, derive an in-depth map expression photoreceptors. Third, use efficient CRISPR-Cas9 based mutagenesis screen null phenotypes F0 larvae (F0 screening) as fast, efficient, versatile technique assess involvement candidate generation subtypes. first show that known can be easily replicated method: loss S cones foxq2 mutants rods nr2e3 mutants. then novel functions factor Tbx2, demonstrating plays distinct roles controlling all subtypes retina. Our study provides roadmap discover additional involved process. Additionally, explore four unknown function (Skor1a, Sall1a, Lrrfip1a, Xbp1), find no evidence their This dataset screening method will valuable way genes many essential aspects biology.

Language: Английский

Citations

16
Zebrafish larvae use stimulus intensity and contrast to estimate distance to prey DOI Creative Commons
Biswadeep Khan, On-mongkol Jaesiri,

Ivan P. Lazarte

et al.

Current Biology, Journal Year: 2023, Volume and Issue: 33(15), P. 3179 - 3191.e4

Published: July 11, 2023

Language: Английский

Citations

15
The vertebrate retina: a window into the evolution of computation in the brain DOI Creative Commons
Tom Baden

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 57, P. 101391 - 101391

Published: April 17, 2024

Animal brains are probably the most complex computational machines on our planet, and like everything in biology, they product of evolution. Advances developmental palaeobiology have been expanding general understanding how nervous systems can change at a molecular structural level. However, these changes translate into altered function — that is, 'computation' remains comparatively sparsely explored. What, concretely, does it mean for neuronal computation when neurons their morphology connectivity, new appear or old ones disappear, transmitter slowly modified over many generations? And evolution use possible knobs dials to constantly tune give rise amazing diversity animal behaviours we see today? Addressing major gaps benefits from choosing suitable model system. Here, I present vertebrate retina as one perhaps unusually promising candidate. The is ancient displays highly conserved core organisational principles across entire lineage, alongside myriad adjustments extant species were shaped by history visual ecology. Moreover, logic readily interrogated experimentally, existing retinal circuits handful serve an anchor exploring circuit adaptations tree life, fish deep aphotic zone oceans eagles soaring high up sky.

Language: Английский

Citations

5
Kinematically distinct saccades are used in a context-dependent manner by larval zebrafish DOI Creative Commons
Charles K. Dowell, Joanna Lau, Paride Antinucci

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(19), P. 4382 - 4396.e5

Published: Sept. 4, 2024

Language: Английский

Citations

5
Distributed chromatic processing at the interface between retina and brain in the larval zebrafish DOI Creative Commons
Drago Guggiana-Nilo,

Clemens Riegler,

Mark Hübener

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(9), P. 1945 - 1953.e5

Published: Feb. 26, 2021

Larval zebrafish (Danio rerio) are an ideal organism for studying color vision, as their retina possesses four types of cone photoreceptors, covering most the visible range and into UV.1Raymond P.A. Barthel L.K. Curran G.A. Developmental patterning rod photoreceptors in embryonic zebrafish.J. Comp. Neurol. 1995; 359: 537-550Crossref PubMed Scopus (254) Google Scholar,2Robinson J. Schmitt E.A. Hárosi F.I. Reece R.J. Dowling J.E. Zebrafish ultraviolet visual pigment: absorption spectrum, sequence, localization.Proc. Natl. Acad. Sci. USA. 1993; 90: 6009-6012Crossref (191) Scholar Additionally, eye nervous systems accessible to imaging, given that they naturally transparent.3Spence R. Gerlach G. Lawrence C. Smith The behaviour ecology zebrafish, Danio rerio.Biol. Rev. Camb. Philos. Soc. 2008; 83: 13-34Crossref (627) Scholar, 4Portugues Feierstein C.E. Engert F. Orger M.B. Whole-brain activity maps reveal stereotyped, distributed networks visuomotor behavior.Neuron. 2014; 81: 1328-1343Abstract Full Text PDF (163) 5Ahrens Robson D.N. Li J.M. Keller P.J. functional imaging at cellular resolution using light-sheet microscopy.Nat. Methods. 2013; 10: 413-420Crossref (737) Recent studies have found that, through a set wavelength-range-specific horizontal, bipolar, retinal ganglion cells (RGCs),6Zimmermann M.J.Y. Nevala N.E. Yoshimatsu T. Osorio D. Nilsson D.-E. Berens P. Baden differentially process across space match natural scenes.Curr. Biol. 2018; 28: 2018-2032.e5Abstract (63) 7Connaughton V.P. Nelson Spectral responses horizontal include tetraphasic response novel UV-dominated triphasic response.J. Neurophysiol. 2010; 104: 2407-2422Crossref (34) 8Zhou M. Bear Roberts Janiak F.K. Semmelhack asymmetrically encode spectral temporal information space.Curr. 2020; 30: 2927-2942.e7Abstract (10) 9Yoshimatsu Schröder Fovea-like photoreceptor specializations underlie single UV driven prey-capture behavior zebrafish.Neuron. 107: 320-337.e6Abstract (22) relays tetrachromatic several retinorecipient areas (RAs).10Ma Kler S. Pan Y.A. Structural neural connectivity analysis with restricted anterograde transneuronal viral labeling quantitative brain mapping.Front. Neural Circuits. 13: 85Crossref (5) 11Wulliman M.F. Rupp B. Reichert H. Neuroanatomy Brain: A Topological Atlas. Birkhäuser, 2012Google 12Bartel Colourfulness possible measure object proximity larval brain.bioRxiv. https://doi.org/10.1101/2020.12.03.410241Crossref (0) 13Fornetto Tiso N. Pavone F.S. Vanzi Colored stimuli evoke spectrally tuned neuronal central system larvae.BMC 18: 172Crossref (6) main RA is optic tectum, receiving 97% RGC axons via neuropil mass termed arborization field 10 (AF10).14Robles E. Laurell Baier projectome reveals brain-area-specific representations generated by cell diversity.Curr. 24: 2085-2096Abstract (84) Scholar,15Burrill J.D. Easter Jr., S.S. Development retinofugal projections (Brachydanio rerio).J. 1994; 346: 583-600Crossref (182) Here, we aim understand processing chromatic signals interface between RGCs major targets. We used 2-photon calcium separately neurons different awake animals. find widespread throughout brain, large variety among RGCs, even greater diversity Specific combinations enriched specific nuclei, but there no structure. In this pathway, connection AF10 observe key elements processing, such enhanced signal decorrelation improved decoding.16Niessing Friedrich R.W. Olfactory pattern classification discrete network states.Nature. 465: 47-52Crossref (124) Scholar,17Johnson K.O. coding.Neuron. 2000; 26: 563-566Abstract (26) richer stimulus revealed these enhancements occur context more code facilitating association small vertebrate brain.

Language: Английский

Citations

29