NEUROBIOLOGICAL ASPECTS OF PATHOGENETIC MECHANISMS IN THE DEVELOPMENT OF POST-TRAUMATIC STRESS DISORDER (LITERATURE REVIEW) DOI Creative Commons
Oleksandr Oleshko, Kristina Berladir, Tetiana Oleshko

и другие.

Eastern Ukrainian Medical Journal, Год журнала: 2025, Номер 13(1), С. 39 - 54

Опубликована: Янв. 1, 2025

Post-traumatic stress disorder (PTSD) occurs as a result of exposure to life-threatening traumatic event or situation involving violence. The main manifestations PTSD are obsessive re-experiencing the event, increased nervous arousal, avoidance stimuli related emotional and cognitive disorders that persist for long time. This mental is exhausting causes changes make it difficult sometimes impossible patients with function professionally socially. results in significant clinical burden high socioeconomic costs. Materials methods. authors have reviewed more than 100 scientific papers from world literature on problems diagnosis, symptoms, pathophysiological neurobiological mechanisms play an important role development can be used key elements choice treatment measures. Results. multifactorial disease, therefore, numerous factors involved its occurrence progression. immediate response activation neuroendocrine autonomic systems release adrenaline norepinephrine. involvement hypothalamic-pituitary-adrenal system subsequent secretion cortisol may trigger development. A link has been found between activity noradrenergic system, glucocorticoid exposure, impaired interaction neurons amygdala prefrontal cortex. In addition, glucocorticoids associated immune neuroinflammation. Inflammatory cytokines regulate modify functioning neurotransmitters such serotonin dopamine, which contributes onset progression symptoms. Conclusions. data large number studies allow us confirm following pathogenesis PTSD. These include vegetative regulation, dysfunction immunological regulatory inflammatory mechanisms, dysregulation monoaminergic transmission system. Further study pathogenetic pathways will better implementation strategy medical care

Язык: Английский

A tissue-like neurotransmitter sensor for the brain and gut DOI
Jinxing Li, Yuxin Liu, Lei Yuan

и другие.

Nature, Год журнала: 2022, Номер 606(7912), С. 94 - 101

Опубликована: Июнь 1, 2022

Язык: Английский

Процитировано

313
Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators DOI
Zhaofa Wu, Dayu Lin, Yulong Li

и другие.

Nature reviews. Neuroscience, Год журнала: 2022, Номер 23(5), С. 257 - 274

Опубликована: Март 31, 2022

Язык: Английский

Процитировано

165
The Neuropsychology of Anxiety DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Год журнала: 2024, Номер unknown

Опубликована: Май 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Язык: Английский

Процитировано

74
A mosaic of cost–benefit control over cortico-striatal circuitry DOI
Andrew Westbrook, Michael J. Frank, Roshan Cools

и другие.

Trends in Cognitive Sciences, Год журнала: 2021, Номер 25(8), С. 710 - 721

Опубликована: Июнь 10, 2021

Язык: Английский

Процитировано

71
Serotonin and dopamine modulate aging in response to food odor and availability DOI Creative Commons
Hillary Miller, Shijiao Huang,

Elizabeth S. Dean

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Июнь 7, 2022

Abstract An organism’s ability to perceive and respond changes in its environment is crucial for health survival. Here we reveal how the most well-studied longevity intervention, dietary restriction, acts in-part through a cell non-autonomous signaling pathway that inhibited by presence of attractive smells. Using an intestinal reporter key gene induced restriction but suppressed smells, identify three compounds block food odor effects C. elegans , thereby increasing as mimetics. These clearly implicate serotonin dopamine limiting lifespan response odor. We further chemosensory neuron likely perceives odor, enteric signals receptor 5-HT1A/SER-4, dopaminergic DRD2/DOP-3. Aspects this are conserved D. melanogaster . Thus, blocking antagonism or receptors plausible approach mimic benefits restriction.

Язык: Английский

Процитировано

44
Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex DOI Creative Commons
Seth R. Batten,

Alec Hartle,

Leonardo S. Barbosa

и другие.

Cell Reports, Год журнала: 2025, Номер 44(1), С. 115162 - 115162

Опубликована: Янв. 1, 2025

Words represent a uniquely human information channel-humans use words to express thoughts and feelings assign emotional valence experience. Work from model organisms suggests that assignments are carried out in part by the neuromodulators dopamine, serotonin, norepinephrine. Here, we ask whether signaling these extends word semantics humans measuring sub-second neuromodulator dynamics thalamus (N = 13) anterior cingulate cortex 6) of individuals evaluating positive, negative, neutrally valenced words. Our combined results suggest modulate release both cortex, but with region- valence-specific response patterns, as well hemispheric dependence for dopamine cingulate. Overall, experiments provide evidence neuromodulator-dependent humans, not simple one-valence-per-transmitter fashion.

Язык: Английский

Процитировано

2
A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity “Shati/Nat8l-BDNF System” in the Dorsal Striatum DOI Creative Commons

Hajime Miyanishi,

Atsumi Nitta

Pharmaceuticals, Год журнала: 2021, Номер 14(9), С. 889 - 889

Опубликована: Сен. 1, 2021

Depression is one of the most common mental diseases, with increasing numbers patients globally each year. In addition, approximately 30% depression are resistant to any treatment and do not show an expected response first-line antidepressant drugs. Therefore, novel agents strategies required. Although triggered by post-birth stress, while some individuals pathology depression, others remain resilient. The molecular mechanisms underlying stress sensitivity unknown. Brain-derived neurotrophic factor (BDNF) has both pro- anti-depressant effects, dependent on brain region. Considering strong region-specific contribution BDNF pathogenesis, regulation in whole a beneficial strategy for depression. We reviewed finding function dorsal striatum, which induces vulnerability social addition recent research progress regarding regional functions BDNF, including prefrontal cortex, hippocampus, nucleus accumbens. Striatal regulated Shati/Nat8l, N-acetyltransferase through epigenetic regulation. Targeting Shati/Nat8l would allow be striatum-specifically regulated, striatal Shati/Nat8l-BDNF pathway could promising therapeutic agent modulating stress.

Язык: Английский

Процитировано

51
Nigrostriatal dopamine pathway regulates auditory discrimination behavior DOI Creative Commons
Allen P. F. Chen, Jeffrey M. Malgady, Chen Lu

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Окт. 8, 2022

Abstract The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated perceptual decision-making, transforming stimuli to action outcomes. Despite its known connections diverse neurological conditions, dopaminergic modulation sensory striatal neuronal activity and behavioral influences remain unknown. We demonstrated that optogenetic inhibition projections from substantia nigra pars compacta specifically impairs mouse choice performance but not movement an frequency discrimination task. In vivo dopamine calcium imaging freely behaving mice revealed this projection modulates tone representations, tone-evoked release inversely correlated with evidence strength tones. Optogenetic D1-receptor expressing neurons pharmacological D1 receptors dampened accuracy. Our study uncovers a phasic mechanism within nigrostriatal system regulates decisions by modulating ongoing perception.

Язык: Английский

Процитировано

36
Transdiagnostic computations of uncertainty: towards a new lens on intolerance of uncertainty DOI Creative Commons

Timothy R. Sandhu,

Bowen Xiao, Rebecca Lawson

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 148, С. 105123 - 105123

Опубликована: Март 11, 2023

People radically differ in how they cope with uncertainty. Clinical researchers describe a dispositional characteristic known as "intolerance of uncertainty", tendency to find uncertainty aversive, reported be elevated across psychiatric and neurodevelopmental conditions. Concurrently, recent research computational psychiatry has leveraged theoretical work characterise individual differences processing. Under this framework, people estimate different forms can contribute mental health difficulties. In review, we briefly outline the concept intolerance within its clinical context, argue that mechanisms underlying construct may further elucidated through modelling individuals make inferences about We will review evidence linking psychopathology computationally specified consider these findings might suggest distinct mechanistic routes towards also discuss implications approach for behavioural pharmacological interventions, well importance cognitive domains subjective experiences studying

Язык: Английский

Процитировано

22
Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange DOI Creative Commons
Seth R. Batten, Dan Bang, Brian H. Kopell

и другие.

Nature Human Behaviour, Год журнала: 2024, Номер 8(4), С. 718 - 728

Опубликована: Фев. 26, 2024

Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able study neuromodulator dynamics as interaction unfolds. Here, obtained subsecond estimates of dopamine from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had accept or reject monetary offers varying fairness computer players. They rejected more in than condition, an effect context associated higher overall levels but serotonin. Regardless context, relative changes tracked trial-by-trial offer value-akin reward prediction errors-whereas current value. These results show that fluctuations one basal ganglia's main output structures reflect distinct value signals.

Язык: Английский

Процитировано

8