Evaluation of In Vitro Serotonin-Induced Electrochemical Fouling Performance of Boron Doped Diamond Microelectrode Using Fast-Scan Cyclic Voltammetry DOI Creative Commons
Mason L. Perillo,

Bhavna Gupta,

James R. Siegenthaler

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(7), P. 352 - 352

Published: July 19, 2024

Fast-scan cyclic voltammetry (FSCV) is an electrochemical sensing technique that can be used for neurochemical with high spatiotemporal resolution. Carbon fiber microelectrodes (CFMEs) are traditionally as FSCV sensors. However, CFMEs prone to fouling caused by oxidative byproducts of repeated serotonin (5-HT) exposure, which makes them less suitable chronic 5-HT Our team developing a boron-doped diamond microelectrode (BDDME) has previously been shown relatively resistant protein adsorption (biofouling). We sought determine if this BDDME exhibits resistance fouling, we explored on electrodes fabricated either femtosecond laser cutting or physical cleaving. recorded the oxidation current response after 25 injections in flow-injection cell and compared drop from first last injection. The responses were dopamine (DA), known produce minimal stable response. Physical cleaving yielded reduction due CFME cut BDDME. exhibited large increase sensitivity over cleaved An extended stability analysis was conducted all device types following tests. This demonstrated improvement long-term CFMEs, well diminishing laser-cut time. work reports performance when it repeatedly exposed DA 5-HT, informs development chronic, diamond-based sensor neurotransmitter measurements vivo.

Language: Английский

A tissue-like neurotransmitter sensor for the brain and gut DOI
Jinxing Li, Yuxin Liu, Lei Yuan

et al.

Nature, Journal Year: 2022, Volume and Issue: 606(7912), P. 94 - 101

Published: June 1, 2022

Language: Английский

Citations

310
Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators DOI
Zhaofa Wu, Dayu Lin, Yulong Li

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(5), P. 257 - 274

Published: March 31, 2022

Language: Английский

Citations

163
The Neuropsychology of Anxiety DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Language: Английский

Citations

73
A mosaic of cost–benefit control over cortico-striatal circuitry DOI
Andrew Westbrook, Michael J. Frank, Roshan Cools

et al.

Trends in Cognitive Sciences, Journal Year: 2021, Volume and Issue: 25(8), P. 710 - 721

Published: June 10, 2021

Language: Английский

Citations

71
Serotonin and dopamine modulate aging in response to food odor and availability DOI Creative Commons
Hillary Miller, Shijiao Huang,

Elizabeth S. Dean

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 7, 2022

Abstract An organism’s ability to perceive and respond changes in its environment is crucial for health survival. Here we reveal how the most well-studied longevity intervention, dietary restriction, acts in-part through a cell non-autonomous signaling pathway that inhibited by presence of attractive smells. Using an intestinal reporter key gene induced restriction but suppressed smells, identify three compounds block food odor effects C. elegans , thereby increasing as mimetics. These clearly implicate serotonin dopamine limiting lifespan response odor. We further chemosensory neuron likely perceives odor, enteric signals receptor 5-HT1A/SER-4, dopaminergic DRD2/DOP-3. Aspects this are conserved D. melanogaster . Thus, blocking antagonism or receptors plausible approach mimic benefits restriction.

Language: Английский

Citations

44
Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex DOI Creative Commons
Seth R. Batten,

Alec Hartle,

Leonardo S. Barbosa

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115162 - 115162

Published: Jan. 1, 2025

Words represent a uniquely human information channel-humans use words to express thoughts and feelings assign emotional valence experience. Work from model organisms suggests that assignments are carried out in part by the neuromodulators dopamine, serotonin, norepinephrine. Here, we ask whether signaling these extends word semantics humans measuring sub-second neuromodulator dynamics thalamus (N = 13) anterior cingulate cortex 6) of individuals evaluating positive, negative, neutrally valenced words. Our combined results suggest modulate release both cortex, but with region- valence-specific response patterns, as well hemispheric dependence for dopamine cingulate. Overall, experiments provide evidence neuromodulator-dependent humans, not simple one-valence-per-transmitter fashion.

Language: Английский

Citations

2
Biological and Mechanical Limitations for Chronic Fast‐Scan Cyclic Voltammetry Sensor Design DOI Creative Commons
Mason L. Perillo,

Bhavna Gupta,

Akash Saxena

et al.

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Fast‐scan cyclic voltammetry (FSCV) is a popular approach for real‐time neurochemical sensing. Using carbon‐fiber microelectrode (CFME), sensitive sensing can be achieved in the acute setting with sub‐second resolution monoamine neurotransmitters. However, to study neuropsychiatric conditions and neurological functions, it often of interest perform longitudinal monitoring neurotransmitters over chronic timepoints. Despite notable successes, there remains substantial room improvement performance. Electrode fouling cellular encapsulation that occur following surgical implantation lead diminished sensor performance time. Additionally, working reference electrodes suffer from etching polarization hinder their longevity stability. Here, this work reviews current challenges facing sensors discusses state‐of‐the‐art advancements electrode material device design choices. This covers how biological environment negatively affect mitigate these effects. also provides examples technologies have been developed improve Improvements FSCV as tool neurotransmitter will open new opportunities neurodegenerative diseases, develop feedback systems neuromodulation, explore underpinnings normal brain function behavior.

Language: Английский

Citations

1
A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity “Shati/Nat8l-BDNF System” in the Dorsal Striatum DOI Creative Commons

Hajime Miyanishi,

Atsumi Nitta

Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(9), P. 889 - 889

Published: Sept. 1, 2021

Depression is one of the most common mental diseases, with increasing numbers patients globally each year. In addition, approximately 30% depression are resistant to any treatment and do not show an expected response first-line antidepressant drugs. Therefore, novel agents strategies required. Although triggered by post-birth stress, while some individuals pathology depression, others remain resilient. The molecular mechanisms underlying stress sensitivity unknown. Brain-derived neurotrophic factor (BDNF) has both pro- anti-depressant effects, dependent on brain region. Considering strong region-specific contribution BDNF pathogenesis, regulation in whole a beneficial strategy for depression. We reviewed finding function dorsal striatum, which induces vulnerability social addition recent research progress regarding regional functions BDNF, including prefrontal cortex, hippocampus, nucleus accumbens. Striatal regulated Shati/Nat8l, N-acetyltransferase through epigenetic regulation. Targeting Shati/Nat8l would allow be striatum-specifically regulated, striatal Shati/Nat8l-BDNF pathway could promising therapeutic agent modulating stress.

Language: Английский

Citations

51
Nigrostriatal dopamine pathway regulates auditory discrimination behavior DOI Creative Commons
Allen P. F. Chen, Jeffrey M. Malgady, Chen Lu

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 8, 2022

Abstract The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated perceptual decision-making, transforming stimuli to action outcomes. Despite its known connections diverse neurological conditions, dopaminergic modulation sensory striatal neuronal activity and behavioral influences remain unknown. We demonstrated that optogenetic inhibition projections from substantia nigra pars compacta specifically impairs mouse choice performance but not movement an frequency discrimination task. In vivo dopamine calcium imaging freely behaving mice revealed this projection modulates tone representations, tone-evoked release inversely correlated with evidence strength tones. Optogenetic D1-receptor expressing neurons pharmacological D1 receptors dampened accuracy. Our study uncovers a phasic mechanism within nigrostriatal system regulates decisions by modulating ongoing perception.

Language: Английский

Citations

35
Transdiagnostic computations of uncertainty: towards a new lens on intolerance of uncertainty DOI Creative Commons

Timothy R. Sandhu,

Bowen Xiao, Rebecca Lawson

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 148, P. 105123 - 105123

Published: March 11, 2023

People radically differ in how they cope with uncertainty. Clinical researchers describe a dispositional characteristic known as "intolerance of uncertainty", tendency to find uncertainty aversive, reported be elevated across psychiatric and neurodevelopmental conditions. Concurrently, recent research computational psychiatry has leveraged theoretical work characterise individual differences processing. Under this framework, people estimate different forms can contribute mental health difficulties. In review, we briefly outline the concept intolerance within its clinical context, argue that mechanisms underlying construct may further elucidated through modelling individuals make inferences about We will review evidence linking psychopathology computationally specified consider these findings might suggest distinct mechanistic routes towards also discuss implications approach for behavioural pharmacological interventions, well importance cognitive domains subjective experiences studying

Language: Английский

Citations

22