Dopamine error signal to actively cope with lack of expected reward

Science Advances, Год журнала: 2023, Номер 9(10)

Опубликована: Март 10, 2023

To obtain more of a particular uncertain reward, animals must learn to actively overcome the lack reward and adjust behavior it again. The neural mechanisms underlying such coping with omission remain unclear. Here, we developed task in rats monitor active behavioral switch toward next after no reward. We found that some dopamine neurons ventral tegmental area exhibited increased responses unexpected decreased following opposite well-known signal prediction error (RPE). increase reflected nucleus accumbens correlated adjustment propose these cope expected thus cooperates RPE signal, enabling adaptive robust pursuit ultimately

Язык: Английский

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Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 17, 2024

Abstract Adjusting decision-making under uncertain and dynamic situations is the hallmark of intelligence. It requires a system capable converting feedback information to renew internal value. The anterior cingulate cortex (ACC) involves in error reward events that prompt switching or maintenance current decision strategies. However, it unclear whether how changes stimulus-action mapping during behavioral adaptation are encoded, nor such computation drives adaptation. Here, we tracked ACC activity male mice performing go/no-go auditory discrimination tasks with manipulated stimulus-reward contingencies. Individual neurons integrate outcome value representation next-run trials. Dynamic recruitment them determines learning rate error-guided iteration adaptation, forming non-linear feedback-driven updating secure appropriate switch. Optogenetically suppressing significantly slowed down without interfering execution established strategy.

Язык: Английский

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Medial prefrontal cortex circuitry and social behaviour in autism

Neuropharmacology, Год журнала: 2024, Номер 260, С. 110101 - 110101

Опубликована: Авг. 14, 2024

Язык: Английский

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Presynaptic supervision of cortical spine dynamics in motor learning

Science Advances, Год журнала: 2022, Номер 8(30)

Опубликована: Июль 27, 2022

In mammalian neocortex, learning triggers the formation and turnover of new postsynaptic spines on pyramidal cell dendrites. However, biological principles spine reorganization during remain elusive because identity their presynaptic neuronal partners is unknown. Here, we show that two neural circuits supervise distinct programs dynamics to execute learning. We imaged in motor cortex performed post hoc identification afferent neurons. New appeared formed small transient contacts with corticocortical neurons were eliminated skill acquisition. contrast, persistent axons from thalamic enlarged. These results suggest dendrites use a circuit division labor learning, dynamic teaching top-down intracortical followed by synaptic memory driven axons. Dual supervision may govern diverse neocortex.

Язык: Английский

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Cognitive flexibility: neurobehavioral correlates of changing one’s mind

Cerebral Cortex, Год журнала: 2022, Номер 33(9), С. 5436 - 5446

Опубликована: Ноя. 11, 2022

Behavioral and cognitive flexibility allow adaptation to a changing environment. Most tasks used investigate require switching reactively in response deterministic task-response rules. In daily life, often involves volitional decision change behavior. This can be instigated by environmental signals, but these are frequently unreliable. We report results from novel "change your mind" task, which assesses under uncertainty without the need for rule-based learning. Participants completed two-alternative choice following spurious feedback, were presented with same stimulus again. Subjects had opportunity repeat or their response. Forty healthy participants task while undergoing functional magnetic resonance imaging scan. predominantly repeated changed more when first was incorrect feedback negative. Greater activations found inferior frontal junction, anterior insula (AI), cingulate, dorsolateral prefrontal cortex. Changing responses also accompanied reduced connectivity AI orbitofrontal cortices occipital Using multivariate pattern analysis of brain activity, we predicted 77% reliability whether would mind. These findings extend our understanding life assessing decision-making.

Язык: Английский

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Probing top-down information in neocortical layer 1

Trends in Neurosciences, Год журнала: 2022, Номер 46(1), С. 20 - 31

Опубликована: Ноя. 22, 2022

Язык: Английский

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Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Май 27, 2024

Abstract Unified visual perception requires integration of bottom-up and top-down inputs in the primary cortex (V1), yet organization V1 remains unclear. Here, we used optogenetics-assisted circuit mapping to identify how multiple from higher-order cortical thalamic areas engage excitatory inhibitory neurons. Top-down overlap superficial layers segregate deep layers. Inputs medial secondary (V2M) anterior cingulate (ACA) converge on L6 Pyrs, whereas ventrolateral orbitofrontal (ORBvl) lateral posterior nucleus (LP) are processed parallel Pyr-type-specific subnetworks (Pyr ←ORBvl Pyr ←LP ) drive mutual inhibition between them via local interneurons. Our study deepens understanding modulation mechanisms processing establishes that V2M ACA employ integrated distinct LP ORBvl L5.

Язык: Английский

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Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice

Science Advances, Год журнала: 2022, Номер 8(42)

Опубликована: Окт. 19, 2022

Regret describes recognizing alternative actions could have led to better outcomes. It remains unclear whether regret derives from generalized mistake appraisal or instead comprises dissociable, action-specific processes. Using a neuroeconomic task, we found that mice were sensitive fundamentally distinct types of following exposure chronic social defeat stress manipulations CREB, transcription factor implicated in action. Bias make compensatory decisions after rejecting high-value offers (regret type I) was unique stress-susceptible mice. the converse operation, accepting low-value II), enhanced stress-resilient and absent CREB function either prefrontal cortex nucleus accumbens required suppress I but bidirectionally regulated II. We provide insight into how maladaptive response traits relate forms counterfactual thinking, which steer therapy for mood disorders, such as depression, toward circuit-specific computations through careful description decision narrative.

Язык: Английский

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Error-driven upregulation of memory representations

Communications Psychology, Год журнала: 2025, Номер 3(1)

Опубликована: Янв. 30, 2025

Abstract Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation. However, neurophysiological mechanisms that facilitate post-error learning remain poorly understood. To address this gap, participants performed a feedback-based task and 1-back localizer task. Increased hemodynamic responses were found for internal external origins of evidence, during encoding success as quantified by subsequent recall face-associated memories. A localizer-based machine model displayed network cognitive control regions, including dorsolateral prefrontal cortices, whose activity was related to face-processing evidence fusiform face area. Representation strength higher failed when succeeded. These data enhance our understanding adaptive linking need processing relevant stimulus category.

Язык: Английский

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Locus coeruleus modulation of single-cell representation and population dynamics in the mouse prefrontal cortex during attentional switching

Опубликована: Май 21, 2025

Abstract Behavioral flexibility, the ability to adjust behavioral strategies in response changing environmental contingencies and internal demands, is fundamental cognitive functions. Despite a large body of pharmacology lesion studies, precise neurophysiological mechanisms that underlie flexibility are still under active investigations. This work aimed determine role brainstem-to-prefrontal cortex circuit flexible rule switching. We trained mice perform set-shifting task, which they learned switch attention distinguish complex sensory cues. Using chemogenetic inhibition, we selectively targeted genetically-defined locus coeruleus (LC) neurons or their input medial prefrontal (mPFC). revealed suppressing either LC its mPFC projections severely impaired switching behavior, establishing critical LC-mPFC supporting attentional To uncover substrates deficits, paired endoscopic calcium imaging with inhibition task-performing mice. found prominently responded not only enhanced engagement but also broadened single-neuron tuning task. At population level, disrupted dynamic changes encoding capacity for Our results highlight profound impact ascending on modulating dynamics provide new insights into cellular circuit-level support flexibility.

Язык: Английский

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