Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity

Cell, Год журнала: 2023, Номер 186(3), С. 577 - 590.e16

Опубликована: Янв. 23, 2023

Pleasurable touch is paramount during social behavior, including sexual encounters. However, the identity and precise role of sensory neurons that transduce remain unknown. A population labeled by developmental expression G protein-coupled receptor Mrgprb4 detects mechanical stimulation in mice. Here, we study relevance Mrgprb4-lineage reveal these are required for receptivity sufficient to induce dopamine release brain. Even isolation, optogenetic through back skin a conditioned place preference striking dorsiflexion resembling lordotic copulatory posture. In absence neurons, female mice no longer find male mounts rewarding: supplanted aggression coincident decline nucleus accumbens. Together, findings establish initiate skin-to-brain circuit encoding rewarding quality touch.

Язык: Английский

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The geometry of cortical representations of touch in rodents

Nature Neuroscience, Год журнала: 2023, Номер 26(2), С. 239 - 250

Опубликована: Янв. 9, 2023

Язык: Английский

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A collicular map for touch-guided tongue control

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Acoustic Bioprinting of Patient‐Derived Organoids for Predicting Cancer Therapy Responses

Advanced Healthcare Materials, Год журнала: 2022, Номер 11(13)

Опубликована: Март 31, 2022

Cancer models, which are biologically representative of patient tumors, can predict the treatment responses and help determine most appropriate cancer for individual patients. Here, a point-of-care testing system called acoustically bioprinted patient-derived microtissues (PDMs) that model invasion response in patients with colorectal (CRC), is reported. The PDMs composed tumors healthy organoids be precisely arranged by acoustic bioprinting approach recapulating primary tissue's architecture. Particularly, these tumor efficiently generated apprehend histological, genomic, phenotypical characteristics tumors. Consequently, allow physiologically relevant vitro drug (5-fluorouracil) screens, thus predicting paired patient's to chemotherapy. A correlation between organoid speed normalized spreading further established. It provides quantitative indicator doctors make better decisions on ultimate anus-preserving operation extremely low CRC Thus, combing cultures, this method may open an avenue establish complex 3D tissue models precision personalized medicine.

Язык: Английский

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Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 25, 2024

The feedback projections from cortical layer 6 (L6CT) to the sensory thalamus have long been implicated in playing a primary role gating signaling but remain poorly understood. To causally elucidate full range of effects these projections, we targeted silicon probe recordings whisker thalamocortical circuit awake mice selectively expressing Channelrhodopsin-2 L6CT neurons. Through optogenetic manipulation neurons, multi-site electrophysiological recordings, and modeling circuitry, establish neurons as dynamic modulators ongoing spiking ventral posteromedial nucleus (VPm), either suppressing or enhancing VPm depending on neurons' firing rate synchrony. Differential across excitatory inhibitory sub-populations point an overall influence excitability that could profound implications for regulating ethologically relevant conditions.

Язык: Английский

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Effects of arousal and movement on secondary somatosensory and visual thalamus

eLife, Год журнала: 2021, Номер 10

Опубликована: Ноя. 29, 2021

Neocortical sensory areas have associated primary and secondary thalamic nuclei. While nuclei transmit information to cortex, remain poorly understood. We recorded juxtasomally from somatosensory (POm) visual (LP) of awake mice while tracking whisking pupil size. POm activity correlated with whisking, but not precise whisker kinematics. This coarse movement modulation persisted after facial paralysis thus was due reafference. phenomenon also continued during optogenetic silencing motor cortex lesion superior colliculus, ruling out a efference copy mechanism. Whisking dilation were strongly correlated, possibly reflecting arousal. Indeed LP, which is part the system, tracked equally well, further indicating that does encode per se. The semblance movement-related likely instead global effect arousal on both conclude thalamus monitors behavioral state, rather than movement, may exist alter cortical accordingly.

Язык: Английский

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Symmetry-Based Representations for Artificial and Biological General Intelligence

Frontiers in Computational Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Апрель 14, 2022

Biological intelligence is remarkable in its ability to produce complex behavior many diverse situations through data efficient, generalizable, and transferable skill acquisition. It believed that learning “good” sensory representations important for enabling this, however there little agreement as what a good representation should look like. In this review article we are going argue symmetry transformations fundamental principle can guide our search makes representation. The idea exist (symmetries) affect some aspects of the system but not others, their relationship conserved quantities has become central modern physics, resulting more unified theoretical framework even predict existence new particles. Recently, symmetries have started gain prominence machine too, efficient generalizable algorithms mimic behaviors produced by biological intelligence. Finally, first demonstrations importance brain starting arise neuroscience. Taken together, overwhelming positive effect bring these disciplines suggest they may be an general determines structure universe, constrains nature natural tasks consequently shapes both artificial

Язык: Английский

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Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 17, 2024

Abstract Neuronal responses during behavior are diverse, ranging from highly reliable ‘classical’ to irregular ‘non-classically responsive’ firing. While a continuum of response properties is observed across neural systems, little known about the synaptic origins and contributions diverse network function, perception, behavior. To capture heterogeneous measured auditory cortex rodents performing frequency recognition task, we use novel task-performing spiking recurrent incorporating spike-timing-dependent plasticity. Reliable units contribute differentially task performance via output connections, respectively. Excitatory plasticity shifts distribution while inhibition constrains its diversity. Together both improve with full engagement. The same local patterns inputs predict cortical neurons in vivo whole-cell recordings Thus, function emerge rules.

Язык: Английский

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Learning enhances encoding of time and temporal surprise in mouse primary sensory cortex

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Сен. 20, 2022

Abstract Primary sensory cortex has long been believed to play a straightforward role in the initial processing of information. Yet, superficial layers overall are sparsely active, even during stimulation; additionally, cortical activity is influenced by other modalities, task context, reward, and behavioral state. Our study demonstrates that reinforcement learning dramatically alters representations among longitudinally imaged neurons mouse primary somatosensory cortex. Learning an object detection recruits previously unresponsive neurons, enlarging neuronal population sensitive touch choice. Cortical responses decrease upon repeated stimulus presentation outside task. Moreover, training improves encoding passage time, unexpected deviations trial timing elicit stronger than touches do. In conclusion, exhibit high degree learning-dependent plasticity strongly modulated non-sensory but behaviorally-relevant features, such as surprise.

Язык: Английский

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Active inference through whiskers

Neural Networks, Год журнала: 2021, Номер 144, С. 428 - 437

Опубликована: Сен. 9, 2021

Язык: Английский

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