Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations

Neuron, Год журнала: 2021, Номер 110(1), С. 120 - 138.e4

Опубликована: Окт. 22, 2021

Язык: Английский

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Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales

PLoS Biology, Год журнала: 2024, Номер 22(5), С. e3002614 - e3002614

Опубликована: Май 14, 2024

The processing of sensory information, even at early stages, is influenced by the internal state animal. Internal states, such as arousal, are often characterized relating neural activity to a single “level” defined behavioral indicator pupil size. In this study, we expand understanding arousal-related modulations in systems uncovering multiple timescales dynamics and their relationship activity. Specifically, observed robust coupling between spiking mouse dorsolateral geniculate nucleus (dLGN) thalamus across spanning few seconds several minutes. Throughout all these timescales, 2 distinct modes—individual tonic spikes tightly clustered bursts spikes—preferred opposite phases dynamics. This multi-scale reveals from those captured size per se, locomotion, eye movements. Furthermore, persisted during viewing naturalistic movie, where it contributed differences encoding visual information. We conclude that dLGN under simultaneous influence processes associated with occurring over broad range timescales.

Язык: Английский

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Brain-wide presynaptic networks of functionally distinct cortical neurons

Nature, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Revealing the connectivity of functionally identified individual neurons is necessary to understand how activity patterns emerge and support behaviour. Yet brain-wide presynaptic wiring rules that lay foundation for functional selectivity remain largely unexplored. Cortical neurons, even in primary sensory cortex, are heterogeneous their selectivity, not only stimuli but also multiple aspects Here, investigate underlying pyramidal behavioural state 1–10 somatosensory cortex (S1), we used two-photon calcium imaging, neuropharmacology, single-cell-based monosynaptic input tracing optogenetics. We show state-dependent stable over time. These minimally affected by direct neuromodulatory inputs driven primarily glutamatergic inputs. Analysis networks with distinct profiles revealed although state-related state-unrelated shared a similar pattern local within S1, long-range differed. Individual cortical irrespective properties, received converging from main S1-projecting areas. tracked smaller proportion motor larger thalamic Optogenetic suppression reduced this was externally driven. Our results reveal as substrate preconfigured network dynamics associated state.

Язык: Английский

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Effects of arousal and movement on secondary somatosensory and visual thalamus

eLife, Год журнала: 2021, Номер 10

Опубликована: Ноя. 29, 2021

Neocortical sensory areas have associated primary and secondary thalamic nuclei. While nuclei transmit information to cortex, remain poorly understood. We recorded juxtasomally from somatosensory (POm) visual (LP) of awake mice while tracking whisking pupil size. POm activity correlated with whisking, but not precise whisker kinematics. This coarse movement modulation persisted after facial paralysis thus was due reafference. phenomenon also continued during optogenetic silencing motor cortex lesion superior colliculus, ruling out a efference copy mechanism. Whisking dilation were strongly correlated, possibly reflecting arousal. Indeed LP, which is part the system, tracked equally well, further indicating that does encode per se. The semblance movement-related likely instead global effect arousal on both conclude thalamus monitors behavioral state, rather than movement, may exist alter cortical accordingly.

Язык: Английский

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Layer 1 neocortex: Gating and integrating multidimensional signals

Neuron, Год журнала: 2023, Номер 112(2), С. 184 - 200

Опубликована: Окт. 31, 2023

Язык: Английский

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Attentional modulation of secondary somatosensory and visual thalamus of mice

eLife, Год журнала: 2024, Номер 13

Опубликована: Июнь 24, 2024

Each sensory modality has its own primary and secondary thalamic nuclei. While the nuclei are well understood to relay information from periphery cortex, role of is elusive. We trained head-fixed mice attend one while ignoring a second modality, namely touch ignore vision, or vice versa. Arrays were used record simultaneously somatosensory thalamus (POm) visual (LP). In respond tactile stimuli stimuli, POm was robustly activated by largely unresponsive stimuli. A different pattern observed when touch, with now more during trials. This activity not explained differences in movements (i.e. whisking, licking, pupil dilation) resulting two tasks. Post hoc histological reconstruction array tracks through revealed that subregions varied their degree plasticity. LP exhibited similar phenomena. conclude behavioral training reshapes Secondary same behaviorally relevant, reward-predicting regardless stimulus modality.

Язык: Английский

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Co-coding of head and whisker movements by both VPM and POm thalamic neurons

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 13, 2024

Abstract Rodents continuously move their heads and whiskers in a coordinated manner while perceiving objects through whisker-touch. Studies head-fixed rodents showed that the ventroposterior medial (VPM) posterior (POm) thalamic nuclei code for whisker kinematics, with POm involvement reduced awake animals. To examine VPM coding head kinematics awake, head-free conditions, we recorded neuronal activity tracked movements male mice exploring an open arena. Using optogenetic tagging, found freely moving mice, both equally coded robustly kinematics. The fraction of neurons increased after trimming, ruling out whisker-mediated coding. Optogenetic activation evoked overt kinematic changes leading Our data suggest integrate information can influence during tactile perception.

Язык: Английский

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Cooperative thalamocortical circuit mechanism for sensory prediction errors

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 12, 2023

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance error signals for various neural computations across multiple regions, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory required generating sensory errors in mouse primary visual cortex (V1). Using calcium imaging with optogenetic manipulations mice traverse familiar virtual environment, show that violation animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction specifically amplify input, rather than representing non-specific surprise or difference signal how input deviates from predictions. Selective amplification implemented cooperative mechanism requiring thalamic pulvinar, cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing (SOM) interneurons gate excitatory pulvinar V1, resulting pulvinar-driven response-amplification stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

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Feedforward and disinhibitory circuits differentially control activity of cortical somatostatin interneurons during behavioral state transitions

Cell Reports, Год журнала: 2024, Номер 43(5), С. 114197 - 114197

Опубликована: Май 1, 2024

Interneurons (INs), specifically those in disinhibitory circuits like somatostatin (SST) and vasoactive intestinal peptide (VIP)-INs, are strongly modulated by the behavioral context. Yet, mechanisms which these INs recruited during active states whether their activity is consistent across sensory cortices remain unclear. We now report that mice, locomotor recruits SST-INs primary somatosensory (S1) but not visual (V1) cortex. This diverse engagement of cannot be explained differences VIP-IN function absent presence input, suggesting involvement feedforward pathways. Accordingly, inactivating thalamus, decreasing activity, significantly reduces modulation locomotion. Model simulations suggest can varying ratios VIP- thalamus-driven activity. By integrating with neuromodulation, anticipated to crucial for adapting processing states.

Язык: Английский

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Attentional modulation of secondary somatosensory and visual thalamus of mice

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 25, 2024

ABSTRACT Each sensory modality has its own primary and secondary thalamic nuclei. While the nuclei are well understood to relay information from periphery cortex, role of is elusive. One hypothesis been that may support feature-based attention. If this true, one would also expect activity in different reflect degree which modalities or not behaviorally relevant a task. We trained head-fixed mice attend while ignoring second modality, namely touch ignore vision, vice versa. Arrays were used record simultaneously somatosensory thalamus (POm) visual (LP). In respond tactile stimuli stimuli, POm was robustly activated by largely unresponsive stimuli. A pattern observed when touch, with now more during trials. This explained differences movements (i.e., whisking, licking, pupil dilation) resulting two tasks. Post hoc histological reconstruction array tracks through revealed subregions varied their plasticity. LP exhibited similar phenomena. conclude behavioral training reshapes Secondary relevant, reward-predicting regardless stimulus modality.

Язык: Английский

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