Brain and Language, Год журнала: 2024, Номер 252, С. 105405 - 105405
Опубликована: Апрель 4, 2024
Язык: Английский
Nature Neuroscience, Год журнала: 2024, Номер 27(3), С. 587 - 599
Опубликована: Фев. 16, 2024
Abstract Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural basis, we investigated whether associative involves temporally correlated spiking medial temporal lobe (MTL) neurons that exhibit stimulus-specific tuning. Using single-neuron recordings from patients with epilepsy performing an object–location task, identified object-specific place-specific represented separate elements each memory. When encoded retrieved particular memories, relevant activated together during hippocampal ripples. This ripple-locked coactivity emerged over time as patients’ learning progressed. Between retrieval, timing shifted, suggesting flexibility in interaction MTL ripples according to behavioral demands. Our results are consistent a cellular account memory, which coordinate activity specialized populations facilitate links
Язык: Английский
Процитировано
12
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Янв. 3, 2024
Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during consolidation. Here we show using intracranial recordings from the human amygdala and hippocampus an encoding discrimination task increased awake ripples after of emotional, compared neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity predictive later discrimination. Ripple-locked appears earlier in than mutual information analysis confirms influence hippocampal activity. Finally, joint correct These findings provide electrophysiological evidence that enhance events.
Язык: Английский
Процитировано
10
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Май 22, 2024
Abstract Core features of human cognition highlight the importance capacity to focus on information distinct from events in here and now, such as mind wandering. However, brain mechanisms that underpin these self-generated states remain unclear. An emerging hypothesis is depend process memory replay, which linked sharp-wave ripples (SWRs), are transient high-frequency oscillations originating hippocampus. Local field potentials were recorded hippocampus 10 patients with epilepsy for up 15 days, experience sampling was used describe their association ongoing thought patterns. The SWR rates higher during extended periods time when participants’ thoughts more vivid, less desirable, had imaginable properties, exhibited fewer correlations an external task. These data suggest a role patterns humans daily life.
Язык: Английский
Процитировано
9
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
Abstract Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization rodents, their application as biomarkers to track and treat dysfunction humans is limited by coarse spatial sampling, interference from interictal epileptiform discharges (IEDs), lack of consensus on human SPW-R localization morphology. We demonstrate that mouse hippocampal share spatial, spectral temporal features, which clearly distinct IEDs. In 1024-channel recordings APP/PS1 mice, SPW-Rs were distinguishable IEDs narrow the CA1 pyramidal layer, narrowband frequency peaks, multiple ripple cycles unfiltered local field potential. epilepsy patients, showed similar peaks visible subiculum but absent dentate gyrus. Conversely, a broad extent wide-band power. introduce semi-automated, detection toolbox (“ripmap”) selecting optimal channels separating event waveforms low-dimensional embedding. Our approach improves accuracy, providing firm foundation future research.
Язык: Английский
Процитировано
1
Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 132, С. 181 - 196
Опубликована: Ноя. 24, 2021
Язык: Английский
Процитировано
50
Trends in Cognitive Sciences, Год журнала: 2021, Номер 26(1), С. 53 - 65
Опубликована: Ноя. 23, 2021
Язык: Английский
Процитировано
42
Nature Reviews Psychology, Год журнала: 2022, Номер 1(8), С. 441 - 453
Опубликована: Июнь 13, 2022
Язык: Английский
Процитировано
38
Nature Mental Health, Год журнала: 2023, Номер 1(11), С. 827 - 840
Опубликована: Ноя. 2, 2023
Язык: Английский
Процитировано
20
Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. e0111232023 - e0111232023
Опубликована: Янв. 17, 2024
Direct human brain recordings have confirmed the presence of high-frequency oscillatory events, termed ripples, during awake behavior. While many prior studies focused on medial temporal lobe (MTL) ripples memory retrieval, here we investigate encoding. Specifically, ask whether encoding predict and how memories are subsequently recalled. Detecting from MTL electrodes implanted in 116 neurosurgical participants (
Язык: Английский
Процитировано
8
Brain, Год журнала: 2024, Номер 147(9), С. 2966 - 2982
Опубликована: Май 14, 2024
Abstract Despite advances in understanding the cellular and molecular processes underlying memory cognition, recent successful modulation of cognitive performance brain disorders, neurophysiological mechanisms remain underexplored. High frequency oscillations beyond classic electroencephalogram spectrum have emerged as a potential neural correlate fundamental processes. are detected human mesial temporal lobe neocortical intracranial recordings spanning gamma/epsilon (60–150 Hz), ripple (80–250 Hz) higher ranges. Separate from other non-oscillatory activities, these brief electrophysiological distinct duration, amplitude thought to be generated by coordinated spiking neuronal ensembles within volumes small single cortical column. Although exact origins, physiological roles health disease elusive, they been associated with consolidation processing. Recent studies suggest their involvement encoding recall episodic possible role formation reactivation traces. during encoding, throughout maintenance, right before remembered items, meeting basic definition for an engram activity. The coordination high reactivated across subcortical networks is ideally suited integrating multimodal representations, which can replayed consolidated states wakefulness sleep. shown reflect bursts assembly firing offer promising substrate tracking hypothetical engram.
Язык: Английский
Процитировано
7