Brain Behavior and Immunity,
Год журнала:
2024,
Номер
119, С. 878 - 897
Опубликована: Май 6, 2024
Metabolites
and
compounds
derived
from
gut-associated
bacteria
can
modulate
numerous
physiological
processes
in
the
host,
including
immunity
behavior.Using
a
model
of
oral
bacterial
infection,
we
previously
demonstrated
that
gut-derived
peptidoglycan
(PGN),
an
essential
constituent
cell
envelope,
influences
female
fruit
fly
egg-laying
behavior
by
activating
NF-κB
cascade
subset
brain
neurons.These
findings
underscore
PGN
as
potential
mediator
communication
between
gut
Drosophila,
prompting
further
investigation
into
its
impact
on
all
cells.Through
high-resolution
mass
spectrometry,
now
show
fragments
produced
rapidly
reach
central
nervous
system.In
Addition,
employing
combination
whole-genome
transcriptome
analyses,
comprehensive
genetic
assays,
reporter
gene
systems,
reveal
infection
triggers
dose-dependent
immune
response
perineurial
glia,
forming
continuous
outer
layer
blood-brain
barrier.Furthermore,
demonstrate
persistent
PGN-dependent
activation
glial
cells
correlates
with
reduction
lifespan
early
neurological
decline.Overall,
our
establish
critical
gut-immune-brain
axis
Drosophila.
Circulation Research,
Год журнала:
2022,
Номер
130(8), С. 1112 - 1144
Опубликована: Апрель 14, 2022
The
microbiota-gut-brain-axis
(MGBA)
is
a
bidirectional
communication
network
between
gut
microbes
and
their
host.
Many
environmental
host-related
factors
affect
the
microbiota.
Dysbiosis
defined
as
compositional
functional
alterations
of
microbiota
that
contribute
to
pathogenesis,
progression
treatment
responses
disease.
occurs
when
perturbations
composition
function
exceed
ability
its
host
restore
symbiotic
state.
leads
dysfunctional
signaling
MGBA,
which
regulates
development
host’s
immune,
metabolic,
nervous
systems.
Dysbiosis-induced
dysfunction
MGBA
seen
with
aging
stroke,
linked
common
stroke
risk
such
obesity,
diabetes,
atherosclerosis.
Changes
in
are
also
response
may
impair
recovery
after
injury.
This
review
will
begin
an
overview
tools
used
study
discussion
on
limitations
potential
experimental
confounders.
Relevant
components
introduced
summarized
for
better
understanding
age-related
changes
stroke.
We
then
focus
relationship
aging,
highlighting
all
undergo
can
be
influenced
by
or
even
driven
In
final
section,
current
clinical
preclinical
evidence
role
hypertension,
frailty
summarized,
well
populations.
conclude
describing
microbiota-based
therapies
including
use
pre-/pro-biotics
supplementations
bacterial
metabolites.
Ongoing
progress
this
new
frontier
biomedical
sciences
lead
improved
MGBA’s
impact
human
health
Nature Reviews Gastroenterology & Hepatology,
Год журнала:
2024,
Номер
21(4), С. 222 - 247
Опубликована: Фев. 14, 2024
Crosstalk
between
gut
and
brain
has
long
been
appreciated
in
health
disease,
the
microbiota
is
a
key
player
communication
these
two
distant
organs.
Yet,
mechanisms
through
which
influences
development
function
of
gut–brain
axis
remain
largely
unknown.
Barriers
present
are
specialized
cellular
interfaces
that
maintain
strict
homeostasis
different
compartments
across
this
axis.
These
barriers
include
epithelial
barrier,
blood–brain
barrier
blood–cerebrospinal
fluid
barrier.
ideally
positioned
to
receive
communicate
microbial
signals
constituting
gateway
for
gut–microbiota–brain
communication.
In
Review,
we
focus
on
how
modulation
by
can
constitute
an
important
channel
Moreover,
malfunction
upon
alterations
composition
could
form
basis
various
conditions,
including
often
comorbid
neurological
gastrointestinal
disorders.
Thus,
should
unravelling
molecular
move
from
simplistic
framing
as
'leaky
gut'.
A
mechanistic
understanding
barriers,
especially
during
critical
windows
development,
be
aetiology
The
modulator
This
Review
provides
overview
examines
role
disease.
Cell Reports,
Год журнала:
2022,
Номер
41(2), С. 111461 - 111461
Опубликована: Окт. 1, 2022
Dysbiosis
of
the
maternal
gut
microbiome
during
pregnancy
is
associated
with
adverse
neurodevelopmental
outcomes.
We
previously
showed
that
high-fat
diet
(MHFD)
in
mice
induces
dysbiosis,
social
dysfunction,
and
underlying
synaptic
plasticity
deficits
male
offspring
(F1).
Here,
we
reason
that,
if
HFD-mediated
changes
microbiota
drive
deficits,
then
MHFD-induced
dysbiosis
F1
female
MHFD
would
likewise
impair
F2
behavior.
Metataxonomic
sequencing
reveals
reduced
microbial
richness
among
offspring.
Despite
recovery
MHFD-descendant
mice,
they
display
dysfunction.
Post-weaning
Limosilactobacillus
reuteri
treatment
increases
abundance
short-chain
fatty
acid-producing
taxa
rescues
deficits.
L.
exerts
a
sexually
dimorphic
impact
on
configuration,
increasing
discriminant
between
cohorts.
Collectively,
these
results
show
multigenerational
impacts
HFD-induced
lineage
highlight
potential
microbiome-targeted
interventions
for
disorders.
The ISME Journal,
Год журнала:
2023,
Номер
17(8), С. 1153 - 1166
Опубликована: Июнь 16, 2023
Abstract
The
gut
microbiota
exist
within
a
dynamic
ecosystem
shaped
by
various
factors
that
includes
exposure
to
xenobiotics
such
as
pesticides.
It
is
widely
regarded
the
plays
an
essential
role
in
maintaining
host
health,
including
major
influence
on
brain
and
behaviour.
Given
widespread
use
of
pesticides
modern
agriculture
practices,
it
important
assess
long-term
collateral
effects
these
xenobiotic
exposures
have
composition
function.
Indeed,
studies
using
animal
models
shown
can
induce
negative
impacts
microbiota,
physiology
health.
In
tandem,
there
growing
body
literature
showing
pesticide
be
extended
manifestation
behavioural
impairments
host.
With
increasing
appreciation
microbiota-gut-brain
axis,
this
review
we
whether
pesticide-induced
changes
profiles
functions
could
driving
alterations.
Currently,
diversity
type,
dose
variation
experimental
designs
hinders
direct
comparisons
presented.
Although
many
insights
presented,
mechanistic
connection
between
remains
insufficiently
explored.
Future
experiments
should
therefore
focus
causal
mechanisms
examine
mediator
observed
following
exposure.
Neurobiology of Stress,
Год журнала:
2024,
Номер
30, С. 100629 - 100629
Опубликована: Март 18, 2024
In
recent
years,
an
increasing
attention
has
given
to
the
intricate
and
diverse
connection
of
microorganisms
residing
in
our
gut
their
impact
on
brain
health
central
nervous
system
disease.
There
been
a
shift
mindset
understand
that
drug
addiction
is
not
merely
condition
affects
brain,
it
now
being
recognized
as
disorder
also
involves
external
factors
such
intestinal
microbiota,
which
could
influence
vulnerability
development
addictive
behaviors.
Furthermore,
stress
social
interactions,
are
closely
linked
powerful
modulators
addiction.
This
review
delves
into
mechanisms
through
microbiota-stress-immune
axis
may
shape
work
integrates
preclinical
clinical
evidence
demonstrate
bidirectional
communication
between
stress,
behaviors,
substance
use
disorders
suggesting
microbes
might
modulate
having
significance
Microbial Biotechnology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Advancing
microbiome–gut–brain
axis
science
requires
systematic,
rational
and
translational
approaches
to
bridge
the
critical
knowledge
gaps
currently
preventing
full
exploitation
of
gut
microbiome
as
a
tractable
therapeutic
target
for
gastrointestinal,
mental
brain
health.
Current
research
is
still
marked
by
many
open
questions
that
undermine
widespread
application
humans.
For
example,
lack
mechanistic
understanding
probiotic
effects
means
it
remains
unclear
why
even
apparently
closely
related
strains
exhibit
different
in
vivo.
live
microbial
psychobiotics,
consensus
on
their
adjunct
treatments
conventional
neuromodulators,
use
unmedicated
populations
or
at‐risk
cohorts
with
sub‐clinical
symptomatology
warranted.
This
missing
information
both
sides
equation
when
treating
central
nervous
system
(CNS)
conditions
makes
psychobiotic
challenging,
especially
compared
other
pharmaceutical
functional
food
approaches.
Expediting
transition
from
positive
preclinical
data
proven
benefits
humans
includes
interpreting
promises
pitfalls
animal
behavioural
assays,
well
navigating
mechanism‐informed
decision
making
select
right
microbe(s)
job.
In
this
review,
we
consider
how
these
decisions
can
be
supported
light
accrued
range
clinical
studies
across
healthy,
pathological
study
populations,
where
specific
have
been
evaluated
context
gastrointestinal
physiology,
function
behaviour.
Examples
successful,
partial
unsuccessful
translation
bench
bedside
are
considered.
We
also
discuss
developments
silico
analyses
enhanced
our
moved
towards
pinpointing
host–microbe
interactions
most
important
optimal
gut–brain
function.
Combining
assays
vitro
ex
vivo
domains
incorporating
model
organisms
prime
discovery
pipelines
promising
rationally
selected
candidates.
PLoS Biology,
Год журнала:
2022,
Номер
20(11), С. e3001838 - e3001838
Опубликована: Ноя. 1, 2022
Host-associated
microbiotas
guide
the
trajectory
of
developmental
programs,
and
altered
microbiota
composition
is
linked
to
neurodevelopmental
conditions
such
as
autism
spectrum
disorder.
Recent
work
suggests
that
modulate
behavioral
phenotypes
associated
with
these
disorders.
We
discovered
zebrafish
required
for
normal
social
behavior
reveal
a
molecular
pathway
linking
microbiota,
microglial
remodeling
neural
circuits,
in
this
experimentally
tractable
model
vertebrate.
Examining
neuronal
correlates
behavior,
we
found
restrains
neurite
complexity
targeting
forebrain
neurons
necessary
localization
microglia,
brain-resident
phagocytes
remodel
arbors.
The
also
influences
functions,
including
promoting
expression
complement
signaling
synaptic
factor
c1q
.
Several
distinct
bacterial
taxa
are
individually
sufficient
phenotypes,
suggesting
host
neuroimmune
development
sensitive
feature
common
among
many
bacteria.
Our
results
demonstrate
by
stimulating
circuits
during
early
neurodevelopment
suggest
pathways
new
interventions
multiple
