Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Июль 29, 2022

Human brain organoids replicate much of the cellular diversity and developmental anatomy human brain. However, physiology neuronal circuits within remains under-explored. With high-density CMOS microelectrode arrays shank electrodes, we captured spontaneous extracellular activity from derived induced pluripotent stem cells. We inferred functional connectivity spike timing, revealing a large number weak connections skeleton significantly fewer strong connections. A benzodiazepine increased uniformity firing patterns decreased relative fraction weakly connected edges. Our analysis local field potential demonstrate that contain assemblies sufficient size to co-activate generate potentials their collective transmembrane currents phase-lock spiking activity. These results point for study neuropsychiatric diseases, drug action, effects external stimuli upon networks.

Язык: Английский

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Principles of large-scale neural interactions

Neuron, Год журнала: 2023, Номер 111(7), С. 987 - 1002

Опубликована: Апрель 1, 2023

Язык: Английский

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Over and above frequency: Gamma oscillations as units of neural circuit operations

Neuron, Год журнала: 2023, Номер 111(7), С. 936 - 953

Опубликована: Апрель 1, 2023

Gamma oscillations (30-150 Hz) are widespread correlates of neural circuit functions.These network activity patterns have been described across multiple animal species, brain structures, and behaviors, usually identified based on their spectral peak frequency.Yet, despite intensive investigation, whether gamma implement causal mechanisms specific functions or represent a general dynamic mode operation remains unclear.In this perspective, we review recent advances in the study toward deeper understanding cellular mechanisms, pathways, functional roles.We discuss that given rhythm does not per se any cognitive function but rather constitutes an motif reporting substrates, communication channels, computational operations underlying information processing its generating circuit.Accordingly, propose shifting attention from frequency-based to circuit-level definition oscillations.

Язык: Английский

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Solving the binding problem: Assemblies form when neurons enhance their firing rate—they don’t need to oscillate or synchronize

Neuron, Год журнала: 2023, Номер 111(7), С. 1003 - 1019

Опубликована: Апрель 1, 2023

Язык: Английский

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Distinct roles of forward and backward alpha-band waves in spatial visual attention

eLife, Год журнала: 2023, Номер 12

Опубликована: Март 6, 2023

Previous research has associated alpha-band [8-12 Hz] oscillations with inhibitory functions: for instance, several studies showed that visual attention increases power in the hemisphere ipsilateral to attended location. However, other demonstrated alpha positively correlate perception, hinting at different processes underlying their dynamics. Here, using an approach based on traveling waves, we demonstrate there are two functionally distinct propagating directions. We analyzed EEG recordings from three datasets of human participants performing a covert task (one new dataset N = 16, previously published 16 and 31). Participants were instructed detect brief target by covertly attending screen's left or right side. Our analysis reveals processes: allocating one hemifield top-down waves frontal occipital regions location, both without stimulation. These oscillatory regions. Yet, propagate contralateral Crucially, these forward present only during stimulation, suggesting separate mechanism related processing. Together, results reveal reflected propagation directions, demonstrating importance considering as when characterizing functional role.

Язык: Английский

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Beta: bursts of cognition

Trends in Cognitive Sciences, Год журнала: 2024, Номер 28(7), С. 662 - 676

Опубликована: Апрель 23, 2024

Beta oscillations are linked to the control of goal-directed processing sensory information and timing motor output. Recent evidence demonstrates they not sustained but organized into intermittent high-power bursts mediating timely functional inhibition. This implies there is a considerable moment-to-moment variation in neural dynamics supporting cognition. thus offer new opportunities for studying how inputs selectively processed, reshaped by inhibitory cognitive operations ultimately result actions. method advances reveal diversity beta that provide deeper insights their function underlying circuit activity motifs. We propose brain-wide, spatiotemporal patterns bursting reflect various nonlinear aspects cortical processing.

Язык: Английский

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Cross-hemispheric communication: Insights on lateralized brain functions

Neuron, Год журнала: 2024, Номер 112(8), С. 1222 - 1234

Опубликована: Март 7, 2024

Язык: Английский

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Multiple gamma rhythms carry distinct spatial frequency information in primary visual cortex

PLoS Biology, Год журнала: 2021, Номер 19(12), С. e3001466 - e3001466

Опубликована: Дек. 21, 2021

Gamma rhythms in many brain regions, including the primary visual cortex (V1), are thought to play a role information processing. Here, we report surprising finding of 3 narrowband gamma V1 that processed distinct spatial frequency (SF) signals and had different neural origins. The low (LG; 25 40 Hz) rhythm was generated at superficial layer preferred higher SF compared with spike activity, whereas both medium (MG; 65 Hz), cortical level, high HG; (65 85 originated precortically, lower information. Furthermore, rates powers gammas better performance discriminating edge surface simple objects. These findings suggest reflect dynamics circuitries process system, which may be crucial for multiplexing synchronizing features an object.

Язык: Английский

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Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms

Neuron, Год журнала: 2022, Номер 111(3), С. 405 - 417.e5

Опубликована: Ноя. 16, 2022

Gamma band synchronization can facilitate local and long-range neural communication. In the primary visual cortex, stimulus properties within a specific location determine strength, while match of between distant locations controls synchronization. The basis for differential control global gamma is unknown. Combining electrophysiology, optogenetics, computational modeling, we found that VIP disinhibitory interneurons in mouse cortex linearly scale power locally without changing its tuning. Conversely, they suppress when two regions process non-matched stimuli, tuning coherence globally. Modeling shows like-to-like connectivity across space VIP→SST inhibition capture these opposing effects. neurons thus differentially impact rhythms depending on statistics. They may thereby construct gamma-band filters spatially extended but continuous image features, such as contours, facilitating downstream generation coherent percepts.

Язык: Английский

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Influence of claustrum on cortex varies by area, layer, and cell type

Neuron, Год журнала: 2022, Номер 111(2), С. 275 - 290.e5

Опубликована: Ноя. 10, 2022

Язык: Английский

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