Aberrant Brain Triple-Network Effective Connectivity Patterns in Type 2 Diabetes Mellitus DOI Creative Commons
Yujie Zhang,

Xiao Hui Yin,

Yu‐Chen Chen

и другие.

Diabetes Therapy, Год журнала: 2024, Номер 15(5), С. 1215 - 1229

Опубликована: Апрель 5, 2024

Aberrant brain functional connectivity network is thought to be related cognitive impairment in patients with type 2 diabetes mellitus (T2DM). This study aims investigate the triple-network effective patterns T2DM within and between default mode (DMN), salience (SN), executive control (ECN) their associations declines. In total, 92 98 matched healthy controls (HCs) were recruited underwent resting-state magnetic resonance imaging (rs-fMRI). Spectral dynamic causal modeling (spDCM) was used for analysis triple network. The posterior cingulate cortex (PCC), medial prefrontal (mPFC), lateral (LPFC), supramarginal gyrus (SMG), anterior insula (AINS) selected as regions of interest. Group comparisons performed calculated using fully connected model, relationships alterations well clinical parameters detected. Compared HCs, exhibited increased or decreased Furthermore, duration significantly negatively correlated from r-LPFC mPFC, while body mass index (BMI) positively l-LPFC l-AINS (r = − 0.353, p 0.001; r 0.377, 0.004). These results indicate abnormal model provide new insight into neurological mechanisms dysfunction.

Язык: Английский

The role of temporal cortex in the control of attention DOI Creative Commons
Hamidreza Ramezanpour, Mazyar Fallah

Current Research in Neurobiology, Год журнала: 2022, Номер 3, С. 100038 - 100038

Опубликована: Янв. 1, 2022

Attention is an indispensable component of active vision. Contrary to the widely accepted notion that temporal cortex processing primarily focusses on passive object recognition, a series very recent studies emphasize role structures, specifically superior sulcus (STS) and inferotemporal (IT) cortex, in guiding attention implementing cognitive programs relevant for behavioral tasks. The goal this theoretical paper advance hypothesis network (TAN) entails necessary components actively participate attentional control flexible task-dependent manner. First, we will briefly discuss general architecture with focus STS IT monkeys their modulation attention. Then review evidence from neurophysiological support guidance presence signals. Next, propose mechanistic framework executive cortex. Finally, summarize how they contribute dynamic nature visual ensure behavior.

Язык: Английский

Процитировано

58
Local and long-distance organization of prefrontal cortex circuits in the marmoset brain DOI Creative Commons
Akiya Watakabe, Henrik Skibbe, Ken Nakae

и другие.

Neuron, Год журнала: 2023, Номер 111(14), С. 2258 - 2273.e10

Опубликована: Май 16, 2023

The prefrontal cortex (PFC) has dramatically expanded in primates, but its organization and interactions with other brain regions are only partially understood. We performed high-resolution connectomic mapping of the marmoset PFC found two contrasting corticocortical corticostriatal projection patterns: "patchy" projections that formed many columns submillimeter scale nearby distant "diffuse" spread widely across striatum. Parcellation-free analyses revealed representations gradients these projections' local global distribution patterns. also demonstrated column-scale precision reciprocal connectivity, suggesting contains a mosaic discrete columns. Diffuse showed considerable diversity laminar patterns axonal spread. Altogether, fine-grained reveal important principles long-distance circuits marmosets provide insights into functional primate brain.

Язык: Английский

Процитировано

38
Dissociable neuronal substrates of visual feature attention and working memory DOI Creative Commons
Diego Mendoza-Halliday, Haoran Xu,

Frederico A. C. Azevedo

и другие.

Neuron, Год журнала: 2024, Номер 112(5), С. 850 - 863.e6

Опубликована: Янв. 15, 2024

Attention and working memory (WM) are distinct cognitive functions, yet given their close interactions, it is often assumed that they share the same neuronal mechanisms. We show in macaques performing a WM-guided feature attention task, activity of most neurons areas middle temporal (MT), medial superior (MST), lateral intraparietal (LIP), posterior prefrontal cortex (LPFC-p) displays attentional modulation or WM coding not both. One area thought to play role both functions LPFC-p. To test this, we optogenetically inactivated LPFC-p bilaterally during different task periods. period inactivation reduced LPFC-p, MST, LIP impaired performance. In contrast, did affect performance minimally affected coding. Our results suggest have dissociable substrates plays critical attention, but WM.

Язык: Английский

Процитировано

14
Macaque Brainnetome Atlas: A multifaceted brain map with parcellation, connection, and histology DOI Creative Commons
Yuheng Lu, Yue Cui, Long Cao

и другие.

Science Bulletin, Год журнала: 2024, Номер 69(14), С. 2241 - 2259

Опубликована: Март 15, 2024

The rhesus macaque (Macaca mulatta) is a crucial experimental animal that shares many genetic, brain organizational, and behavioral characteristics with humans. A atlas fundamental to biomedical evolutionary research. However, even though connectivity vital for understanding functions, connectivity-based whole-brain of the has not previously been made. In this study, we created new map, brainnetome (MacBNA), based on anatomical profiles provided by high angular spatial resolution ex vivo diffusion MRI data. consists 248 cortical 56 subcortical regions as well their structural functional connections. parcellation diffusion-based tractography were evaluated invasive neuronal-tracing Nissl-stained images. As demonstrative application, divergence between human brains was mapped using Brainnetome atlases those two species uncover genetic underpinnings changes in structure. resulting resource includes: (1) thoroughly delineated (2) regional profiles, (3) postmortem high-resolution T2-weighted dataset (Brainnetome-8), (4) multi-contrast MRI, neuronal-tracing, histological images collected from single macaque. MacBNA can serve common reference frame mapping multifaceted features across modalities scales integrative investigation characterization organization function. Therefore, it will enrich collaborative platform nonhuman primates facilitate translational comparative neuroscience

Язык: Английский

Процитировано

10
A domain-relevant framework for the development of face processing DOI
Lisa S. Scott, Michael Arcaro

Nature Reviews Psychology, Год журнала: 2023, Номер 2(3), С. 183 - 195

Опубликована: Фев. 6, 2023

Язык: Английский

Процитировано

21
The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition DOI Creative Commons

Loïc Magrou,

Mary Kate P. Joyce, Seán Froudist‐Walsh

и другие.

Cerebral Cortex, Год журнала: 2024, Номер 34(5)

Опубликована: Апрель 9, 2024

The recent publications of the inter-areal connectomes for mouse, marmoset, and macaque cortex have allowed deeper comparisons across rodent vs. primate cortical organization. In general, these show that mouse has very widespread, "all-to-all" connectivity (i.e. a "highly dense" connectome in graph theoretical framework), while primates more modular this review, we highlight relevance differences to function, including example primary visual (V1) which, is interconnected with all other areas, therefore sensory frontal areas. We argue dense benefits multimodal associations, at cost reduced functional segregation. Conversely, expanded cortices structure, where V1 almost exclusively cortices, themselves organized relatively segregated streams, hierarchically higher areas such as prefrontal provide top-down regulation specifying precise information working memory storage manipulation. Increased complexity cytoarchitecture, connectivity, dendritic spine density, receptor expression additionally reveal sharper hierarchical organization cortex. Together, specializations permit separable deconstruction selective reconstruction representations, which essential cognition.

Язык: Английский

Процитировано

9
Prefrontal cortex neuronal ensembles dynamically encode task features during associative memory and virtual navigation DOI Creative Commons
Mohamad Abbass, Benjamin Corrigan, Renée Johnston

и другие.

Cell Reports, Год журнала: 2025, Номер 44(1), С. 115124 - 115124

Опубликована: Янв. 1, 2025

Highlights•Lateral prefrontal cortex neurons are tuned to visuospatial features during navigation•Neurons dynamically mix unconstrained eye position and visual features•Dorsal ventral represent spatial features, respectively•Eye is represented in a different subspace than featuresSummaryNeuronal populations expand their information-encoding capacity using mixed selective neurons. This particularly prominent association areas such as the lateral (LPFC), which integrate information from multiple sensory systems. However, conditions that approximate natural behaviors, it unclear how LPFC neuronal ensembles process space- time-varying about task features. Here, we show that, virtual reality with naturalistic elements requires associative memory, individual primate of task, movements, task-related Neurons dorsal regions more selectivity for space while representing them separate subspace. In summary, exhibit dynamic constrained elements, neural can subspaces.Graphical abstract

Язык: Английский

Процитировано

1
Tractography validation Part 2: The use of anatomical model systems and measures for validation DOI
Tim B. Dyrby, Silvio Sarubbo, François Rheault

и другие.

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 511 - 542

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits DOI
Zdravko Petanjek, Ivan Banovac, Dora Sedmak

и другие.

Advances in neurobiology, Год журнала: 2023, Номер unknown, С. 143 - 221

Опубликована: Янв. 1, 2023

Язык: Английский

Процитировано

10
A Whole-Brain Topographic Ontology DOI
Michael Arcaro, Margaret S. Livingstone

Annual Review of Neuroscience, Год журнала: 2024, Номер 47(1), С. 21 - 40

Опубликована: Фев. 16, 2024

It is a common view that the intricate array of specialized domains in ventral visual pathway innately prespecified. What this review postulates it not. We explore origins domain specificity, hypothesizing adult brain emerges from an interplay between domain-general map-based architecture, shaped by intrinsic mechanisms, and experience. argue most fundamental innate organization cortex general, not just pathway, topography governs how environment maps onto brain, areas interconnect, ultimately, processes information.

Язык: Английский

Процитировано

4