bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 14, 2024
Abstract
Accurate
mapping
of
brain
functional
subregions
at
an
individual
level
is
crucial.
Task-based
MRI
(tfMRI)
captures
subject-specific
activation
patterns
during
various
functions
and
behaviors,
facilitating
the
localization
functionally
distinct
subregions.
However,
acquiring
high-quality
tfMRI
time-consuming
resource-intensive
in
both
scientific
clinical
settings.
The
present
study
proposes
a
two-stage
network
model,
TS-AI,
to
individualize
atlas
on
cortical
surfaces
through
prediction
data.
TS-AI
first
synthesizes
battery
task
contrast
maps
for
each
by
leveraging
tract-wise
anatomical
connectivity
resting-state
networks.
These
synthesized
maps,
along
with
feature
networks,
are
then
fed
into
end-to-end
deep
neural
atlas.
enables
be
used
parcellation
without
acquisition
actual
fMRI
scans.
In
addition,
novel
consistency
loss
designed
assign
vertices
similar
features
same
parcel,
which
increases
specificity
mitigates
overfitting
risks
caused
absence
ground
truth.
individualized
parcellations
were
validated
assessing
test-retest
reliability,
homogeneity,
cognitive
behavior
using
diverse
reference
atlases
datasets,
demonstrating
superior
performance
generalizability
TS-AI.
Sensitivity
analysis
yielded
insights
region-specific
influencing
variation
regionalization.
identified
accelerated
shrinkage
medial
temporal
cingulate
parcels
progression
Alzheimer’s
disease,
suggesting
its
potential
research
applications.
The Innovation,
Год журнала:
2025,
Номер
6(2), С. 100755 - 100755
Опубликована: Янв. 6, 2025
Chimpanzees
(Pan
troglodytes)
are
one
of
humans'
closest
living
relatives,
making
them
the
most
directly
relevant
comparison
point
for
understanding
human
brain
evolution.
Zeroing
in
on
differences
connectivity
between
humans
and
chimpanzees
can
provide
key
insights
into
specific
evolutionary
changes
that
might
have
occurred
along
lineage.
However,
such
comparisons
hindered
by
absence
cross-species
atlases
established
within
same
framework.
To
address
this
gap,
we
developed
Chimpanzee
Brainnetome
Atlas
(ChimpBNA)
using
a
connectivity-based
parcellation
Leveraging
new
resource,
found
substantial
divergence
patterns
two
species
across
association
cortices,
notably
lateral
temporal
dorsolateral
prefrontal
cortex.
These
deviate
sharply
from
pattern
cortical
expansion
observed
when
comparing
to
chimpanzees,
highlighting
more
complex
nuanced
evolution
than
previously
recognized.
Additionally,
identified
regions
displaying
connectional
asymmetries
differed
species,
likely
resulting
divergence.
Genes
highly
expressed
divergent
connectivities
were
enriched
cell
types
crucial
projection
circuits
synapse
formation,
whose
pronounced
expression
hint
at
genetic
influences
neural
circuit
development,
function,
Our
study
provides
fine-scale
chimpanzee
atlas
highlights
chimpanzee-human
rigorous
comparative
manner.
In
addition,
these
results
suggest
potential
gene
correlates
species-specific
linking
neuroimaging
data,
offering
human-unique
cognitive
capabilities.
IEEE Transactions on Medical Imaging,
Год журнала:
2024,
Номер
43(9), С. 3343 - 3353
Опубликована: Апрель 24, 2024
Individual
brains
vary
greatly
in
morphology,
connectivity
and
organization.
Individualized
brain
parcellation
is
capable
of
precisely
localizing
subject-specific
functional
regions.
However,
most
individualization
approaches
have
examined
single
modalities
data
not
generalized
to
nonhuman
primates.
The
present
study
proposed
a
novel
multimodal
connectivity-based
individual
(MCIP)
method,
which
optimizes
within-region
homogeneity,
spatial
continuity
similarity
reference
atlas
with
the
fusion
personal
anatomical
connectivity.
Comprehensive
evaluation
demonstrated
that
MCIP
outperformed
state-of-the-art
methods
terms
predictability
cognitive
measures,
heritability,
reproducibility
generalizability
across
species.
Comparative
investigation
showed
higher
topographic
variability
humans
than
macaques.
Therefore,
provides
improved
accurate
reliable
mapping
regions
over
existing
at
an
level
species,
could
facilitate
comparative
translational
neuroscience
research.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
The
marmoset
is
a
highly
vocal
platyrrhine
monkey
that
shares
key
anatomical
and
functional
features
with
humans,
providing
unique
opportunity
to
illuminate
the
phylogenetic
origins
of
diverging
connectivity
profiles
their
transformations
throughout
evolution.
Although
similarity
vocalization
between
humans
has
been
reported,
whether
marmosets
possess
an
arcuate
fasciculus
homolog
not
known.
In
this
study,
we
delineated
white
matter
tracts
in
marmosets,
establishing
homologies
those
observed
other
primates,
including
macaques,
chimpanzees,
humans.
presence
was
confirmed
by
tracer
ultra-high-resolution
diffusion
magnetic
resonance
imaging
datasets.
Using
blueprint
approach,
compared
cortical
patterns
across
these
species
found
terminates
ventral
frontal
cortex,
exceeds
something
corroborated
quantitative
analyses
after
transforming
all
brains
into
common
space.
To
explore
fasciculus’
support
for
species-specific
vocalizations,
activation
communications
were
associated
connectivity.
Collectively,
our
findings
suggest
dorsal
pathway,
which
emerged
early
evolution,
evolved
convergently
despite
distant
kindship.
Brain Structure and Function,
Год журнала:
2024,
Номер
229(8), С. 2045 - 2057
Опубликована: Авг. 27, 2024
The
brain
atlas
is
essential
for
exploring
the
anatomical
structure
and
function
of
brain.
Non-human
primates,
such
as
cynomolgus
macaque,
have
received
increasing
attention
due
to
their
genetic
similarity
humans.
However,
current
macaque
atlases
only
offer
coarse
sections
with
intervals
along
coronal
direction,
failing
meet
needs
single-cell
resolution
studies
in
functional
multi-omics
research
To
address
this
issue,
we
utilized
fluorescence
micro-optical
sectioning
tomography
obtain
sub-micron
cytoarchitectonic
images
at
sagittal
plane.
Based
on
obtained
8000
image
sequences,
a
reference
comprising
45
was
created,
delineating
270
regions
other
than
cortex.
Additionally,
website
established
share
corresponding
data.
This
study
expected
provide
an
dataset
tool
scientists
studying
