Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects DOI Creative Commons
Hao-Jui Weng, Quoc Thao Trang Pham,

Chia-Wei Chang

и другие.

Pharmaceuticals, Год журнала: 2022, Номер 15(7), С. 892 - 892

Опубликована: Июль 19, 2022

Pain and itch are both important manifestations of various disorders, such as herpes zoster, atopic dermatitis, psoriasis. Growing evidence suggests that sensations have shared mediators, overlapping neural circuitry, similarities in sensitization processes. In fact, pain coexist some disorders. Determining pharmaceutical agents targets for treating concurrently is scientific clinical relevance. Here we review the neurobiology discuss well novel compounds effective concurrent treatment these sensations.

Язык: Английский

Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis DOI Open Access
Dimitra Koumaki, Stamatios Gregoriou, George Evangelou

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(6), С. 2091 - 2091

Опубликована: Март 7, 2023

Atopic dermatitis (AD) is a common highly pruritic chronic inflammatory skin disorder affecting 5–20% of children worldwide, while the prevalence in adults varies from 7 to 10%. Patients with AD experience intense pruritus that could lead sleep disturbance and impaired quality life. Here, we analyze pathophysiology itchiness AD. We extensively review histamine-dependent histamine-independent pruritogens. Several receptors, substance P, secreted molecules, chemokines, cytokines are involved as mediators itch. also, summarize new emerging antipruritic drugs atopic dermatitis.

Язык: Английский

Процитировано

6
Pruritus Is Associated with an Increased Risk for the Diagnosis of Autoimmune Skin Blistering Diseases: A Propensity-Matched Global Study DOI Creative Commons
Ulrike Raap, Maren M. Limberg, Khalaf Kridin

и другие.

Biomolecules, Год журнала: 2023, Номер 13(3), С. 485 - 485

Опубликована: Март 6, 2023

Autoimmune bullous skin diseases (AIBDs), such as pemphigoid (BP) and pemphigus, are characterized caused by autoantibodies targeting structural proteins. In BP, clinical experience recent systematic evaluation identified pruritus to be common an important cause of impaired quality life. Furthermore, chronic may the sole symptom BP. a retrospective study recently documented high prevalence pruritus. The temporal relation between BP/pemphigus are, however, unknown. Likewise, presence in AIBDs other than BP pemphigus is To address this, we performed propensity-matched cohort studies using TriNetX, providing real-world patient data (i) assess risk develop following diagnosis (ii) vice versa. We assessed this eight AIBDs: mucous membrane (MMP), epidermolysis bullosa acquisita, dermatitis herpetiformis, lichen planus pemphigoides (LPP), vulgaris, foliaceous, paraneoplastic (PNP). For all AIBDs, was associated with increased for subsequent each investigated 1,717,744 cases (pruritus) compared controls. observed hazard ratios ranged from 4.2 (CI 3.2–5.5; p < 0.0001) MMP 28.7 3.9–211.3; LPP. Results were confirmed two subgroup analyses. When restricting observation time 6 months after onset, most HRs noticeably increased, e.g., 6.9 6.2–7.9; 23.3 17.0–31.8; Moreover, frequently developed any except PNP. Thus, should considered differential patients

Язык: Английский

Процитировано

4
Clinical Management of Neuropathic Itch DOI

Kelsey L. Auyeung,

Blair A. Jenkins, Brian Kim

и другие.

JAMA Dermatology, Год журнала: 2023, Номер 159(12), С. 1391 - 1391

Опубликована: Сен. 20, 2023

This JAMA Network Insight reviews the underlying mechanisms and management of peripheral sensory itch conditions.

Язык: Английский

Процитировано

4
Prurito en dermatología. Generalidades y pruritógenos. Parte 1 DOI Creative Commons
F.J. Navarro‐Triviño

Actas Dermo-Sifiliográficas, Год журнала: 2023, Номер 114(6), С. 512 - 522

Опубликована: Март 23, 2023

Pruritus is the most common symptom of dermatologic and systemic diseases. The diagnosis pruritus clinical, although additional tests may be necessary to identify or confirm cause. Translational medicine has led discovery new mediators itch, pruritogens, as well receptors. Knowing how properly recognize main pathway that mediates itch in each patient key successful treatment. Although histaminergic predominates conditions like urticaria drug-induced pruritus, it nonhistaminergic nearly all other skin diseases covered this review. Part 1 2-part review discusses classification testing, pathophysiology pruritogens implicated (including cytokines molecules), central sensitization itch.

Язык: Английский

Процитировано

3
[Translated article] Pruritus in Dermatology: Part 1—General Concepts and Pruritogens DOI Creative Commons
F.J. Navarro‐Triviño

Actas Dermo-Sifiliográficas, Год журнала: 2023, Номер 114(6), С. T512 - T522

Опубликована: Май 10, 2023

Pruritus is the most common symptom of dermatologic and systemic diseases. The diagnosis pruritus clinical, although additional tests may be necessary to identify or confirm cause. Translational medicine has led discovery new mediators itch, pruritogens, as well receptors. Knowing how properly recognize main pathway that mediates itch in each patient key successful treatment. Although histaminergic predominates conditions like urticaria drug-induced pruritus, it nonhistaminergic nearly all other skin diseases covered this review. Part 1 2-part review discusses classification testing, pathophysiology pruritogens implicated (including cytokines molecules), central sensitization itch.

Язык: Английский

Процитировано

1
The Fifth Bioelectronic Medicine Summit: today’s tools, tomorrow’s therapies DOI Creative Commons
Eric H. Chang,

Arielle Gabalski,

Tomás Huerta

и другие.

Bioelectronic Medicine, Год журнала: 2023, Номер 9(1)

Опубликована: Окт. 5, 2023

Abstract The emerging field of bioelectronic medicine (BEM) is poised to make a significant impact on the treatment several neurological and inflammatory disorders. With BEM therapies being recently approved for clinical use others in late-phase trials, 2022 summit was timely scientific meeting convening wide range experts discuss latest developments field. Summit held over two days New York with more than thirty-five invited speakers panelists comprised researchers from both academia industry. goal bring international leaders together advances cultivate collaborations this that incorporates aspects neuroscience, physiology, molecular medicine, engineering, technology. This Meeting Report recaps findings discussed at summarizes main rapidly advancing interdisciplinary Our hope will encourage industry push forward generate new multidisciplinary form basis discoveries we can next Summit.

Язык: Английский

Процитировано

1
An excitatory neural circuit for descending inhibition of itch processing DOI Creative Commons
Guangyan Wu,

Ruo-Xuan Li,

Ju Liu

и другие.

Cell Reports, Год журнала: 2024, Номер 43(12), С. 115062 - 115062

Опубликована: Дек. 1, 2024

Itch serves as a self-protection mechanism against harmful external agents, whereas uncontrolled and persistent itch severely influences the quality of life patients aggravates their diseases. Unfortunately, existing treatments are largely ineffective. The current difficulty in treatment may be closely related to fact that central neural mechanisms underlying processing, especially descending inhibition itch, poorly understood. Here, we demonstrate an excitatory circuit from rostral anterior cingulate cortex pyramidal (rACC

Язык: Английский

Процитировано

0
In vitro models for investigating itch DOI Creative Commons
Hendrik Mießner, Judith A. Seidel, Ewan St. John Smith

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 15

Опубликована: Окт. 26, 2022

Itch (pruritus) is a sensation that drives desire to scratch, behavior observed in many animals. Although generally short-lasting and not causing harm, there are several pathological conditions where chronic itch hallmark symptom which prolonged scratching can induce damage. Finding medications counteract the of has proven difficult due molecular complexity involves multitude triggers, receptors signaling pathways between skin, immune nerve cells. While much been learned about pruritus from vivo animal models, they have limitations corroborate necessity for transition more human disease-like models. Also, reducing use should be encouraged research. However, conducting experiments also ethically challenging. Thus, clear need surrogate models used pre-clinical investigation mechanisms itch. Most vitro research focus on known pruritogens. For this, sensory neurons different types skin and/or cells stimulated 2D or 3D co-culture, factors such as neurotransmitter cytokine release measured. There however simplistic example, all naturally occurring cell present no connection itch-sensing organ, central nervous system (CNS). Nevertheless, offer chance investigate otherwise inaccessible specific cell–cell interactions pathways. In recent years, stem cell-based approaches primary emerged viable alternatives standard lines tissue. As increased their complexity, further opportunities elaborated means investigating developed. this review, we introduce latest concepts discuss advantages current provide valuable contributions might help meet unmet clinical refined anti-pruritic substances.

Язык: Английский

Процитировано

2
Intervening GSK3 Signaling Attenuates Cutaneous Inflammation and Itch in Mice: Implication for Future Therapeutic Development DOI Creative Commons
Renkai Zhu, Yang Hua, Shanghai Xue

и другие.

Journal of Investigative Dermatology, Год журнала: 2022, Номер 143(2), С. 335 - 339.e8

Опубликована: Сен. 2, 2022

Язык: Английский

Процитировано

2
Identification of a convergent spinal neuron population that encodes itch DOI Creative Commons
Tayler D. Sheahan, Charles A. Warwick,

Abby Cui

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 2, 2023

Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural circuit basis for itch remains unclear. Here, we used two-photon Ca2+ imaging of dorsal horn visualize neuronal populations are activated by itch-inducing agents. We identify convergent population spinal neurons defined expression GRPR. Moreover, discover conveyed brain via GRPR-expressing output target lateral parabrachial nucleus. Further, show nalfurafine, clinically effective kappa opioid receptor agonist, relieves inhibiting GRPR spinoparabrachial neurons. Finally, demonstrate subset persistent, cell-intrinsic oscillations. These experiments provide first population-level view respond pruritic stimuli, pinpoint convey brain, and cellular agonists inhibition itch.

Язык: Английский

Процитировано

0