Free Radical Biology and Medicine, Год журнала: 2024, Номер 220, С. 15 - 27
Опубликована: Апрель 27, 2024
Язык: Английский
Cellular & Molecular Biology Letters, Год журнала: 2023, Номер 28(1)
Опубликована: Июнь 27, 2023
The NOD-like receptor protein 3 (NLRP3) inflammasome is a complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β IL-18. Multiple studies have demonstrated importance of NLRP3 in development inflammation-related diseases, including arthritis, Alzheimer's disease, bowel other autoimmune autoinflammatory diseases. This review first explains activation regulatory mechanism inflammasome. Secondly, we focus on role various Finally, look forward to new methods for targeting treat provide ideas clinical treatment.
Язык: Английский
Процитировано
121
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Янв. 5, 2024
Abstract Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three components: an upstream sensor molecule is connected to downstream effector such as caspase-1 through adapter ASC. Inflammasome formation typically occurs response infectious agents or cellular damage. The active then triggers activation, followed by secretion of pro-inflammatory cytokines pyroptotic cell death. Aberrant activation activity contribute development diabetes, cancer, several cardiovascular neurodegenerative disorders. As result, recent research increasingly focused on investigating mechanisms regulate assembly well potential targeting inflammasomes treat various diseases. Multiple clinical trials currently underway evaluate therapeutic distinct inflammasome-targeting therapies. Therefore, understanding how different disease pathology may have significant implications for developing novel strategies. In this article, we provide summary biological pathological roles health disease. We also highlight key evidence suggests could be strategy new disease-modifying therapies effective conditions.
Язык: Английский
Процитировано
61
Neurochemical Research, Год журнала: 2023, Номер 48(8), С. 2285 - 2308
Опубликована: Март 21, 2023
Язык: Английский
Процитировано
44
Ageing Research Reviews, Год журнала: 2023, Номер 87, С. 101915 - 101915
Опубликована: Март 22, 2023
Язык: Английский
Процитировано
42
Nature Reviews Neurology, Год журнала: 2024, Номер 20(2), С. 67 - 83
Опубликована: Янв. 9, 2024
Язык: Английский
Процитировано
34
Nano Today, Год журнала: 2024, Номер 54, С. 102142 - 102142
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
29
Military Medical Research, Год журнала: 2024, Номер 11(1)
Опубликована: Май 29, 2024
Abstract Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable vital life processes such cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key like biogenesis, dynamics, mitophagy, which have garnered increasing attention from researchers unveil specific molecular mechanisms. this review, we present comprehensive summary of primary mechanisms functions regulators involved major components MQC. Furthermore, critical regulated by MQC its diverse roles progression systemic diseases been described detail. We discuss agonists antagonists targeting MQC, aiming explore potential therapeutic research prospects enhancing stabilize function.
Язык: Английский
Процитировано
29
Brain Behavior and Immunity, Год журнала: 2024, Номер 117, С. 428 - 446
Опубликована: Фев. 7, 2024
Язык: Английский
Процитировано
26
Antioxidants, Год журнала: 2024, Номер 13(2), С. 240 - 240
Опубликована: Фев. 16, 2024
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis, each characterised by distinct clinical manifestations underlying pathological mechanisms. While some cases have a genetic basis, many NDs occur sporadically. Despite their differences, these commonly feature chronic neuroinflammation hallmark. Consensus has recently been reached on the possibility that mitochondria dysfunction protein aggregation can mutually contribute to activation neuroinflammatory response thus onset progression disorders. In present review, we discuss contribution aetiology NDs, highlighting new potential therapeutic targets be identified tackle neurodegenerative processes alleviate pathologies.
Язык: Английский
Процитировано
25
Translational research, Год журнала: 2022, Номер 252, С. 21 - 33
Опубликована: Авг. 9, 2022
Язык: Английский
Процитировано
67