Locomotion-dependent auditory gating to the parietal cortex mediates flexible multisensory decisions DOI Open Access

Ilsong Choi,

Seung‐Hee Lee

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 17, 2024

Abstract Decision-making in mammals is fundamentally based on the integration of several senses. When different sensory inputs guide conflicting outcomes, animals make decisions following prepotent modality. However, neural basis state-dependent flexibility dominance and multisensory remains obscure. Here, we found that locomotion switched auditory-dominant to visual-dominant ones mice with audiovisual conflicts. made decisions, visual representation posterior parietal cortex (PPC) was weakened. Prolonged restored PPC induced visually dominant by inhibiting auditory cortical neurons projecting (AC ). In contrast, it had no effect AC projection striatum, which mediated decisions. Locomotion activated AC-projecting secondary motor neurons, preferentially inhibited neurons. Our findings demonstrate flexible gating afferents association depending locomotor conditions.

Язык: Английский

Synaptic wiring motifs in posterior parietal cortex support decision-making DOI
Aaron T. Kuan, Giulio Bondanelli, Laura N. Driscoll

и другие.

Nature, Год журнала: 2024, Номер 627(8003), С. 367 - 373

Опубликована: Фев. 21, 2024

Язык: Английский

Процитировано

32
Sleep microstructure organizes memory replay DOI Creative Commons
Hongyu Chang, Wenbo Tang,

Annabella M. Wulf

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

6
Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits DOI Creative Commons
Wenbo Tang, Justin D. Shin, Shantanu P. Jadhav

и другие.

Cell Reports, Год журнала: 2023, Номер 42(3), С. 112246 - 112246

Опубликована: Март 1, 2023

The ability to abstract information guide decisions during navigation across changing environments is essential for adaptation and requires the integrity of hippocampal-prefrontal circuitry. hippocampus encodes navigational in a cognitive map, but it remains unclear how maps are transformed circuits support abstraction generalization. Here, we simultaneously record ensembles as rats generalize rules distinct environments. We find that, whereas hippocampal representational maintain specificity separate environments, prefrontal Furthermore, while both structured within neural manifold population activity, they have geometries. Prefrontal geometry enables rule-informative variables, format that generalizes novel conditions existing variable classes. Hippocampal lacks such abstraction. Together, these findings elucidate into geometric representations generalization maintaining memory specificity.

Язык: Английский

Процитировано

33
A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions DOI Creative Commons
Shinichiro Kira, Houman Safaai, Ari S. Morcos

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Апрель 14, 2023

Abstract Decision-making requires flexibility to rapidly switch one’s actions in response sensory stimuli depending on information stored memory. We identified cortical areas and neural activity patterns underlying this during virtual navigation, where mice switched navigation toward or away from a visual cue its match remembered cue. Optogenetics screening V1, posterior parietal cortex (PPC), retrosplenial (RSC) as necessary for accurate decisions. Calcium imaging revealed neurons that can mediate rapid switches by encoding mixture of current These mixed selectivity emerged through task learning predicted the mouse’s choices forming efficient population codes before correct, but not incorrect, choices. They were distributed across cortex, even densest RSC sparsest PPC. propose decisions arises mix memory within visual-parietal-retrosplenial network.

Язык: Английский

Процитировано

31
A cell-type-specific error-correction signal in the posterior parietal cortex DOI Creative Commons
Jonathan Green, Carissa A. Bruno,

Lisa Traunmüller

и другие.

Nature, Год журнала: 2023, Номер 620(7973), С. 366 - 373

Опубликована: Июль 19, 2023

Neurons in the posterior parietal cortex contribute to execution of goal-directed navigation

Язык: Английский

Процитировано

24
Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex DOI Creative Commons
Alex T. Piet,

Nick Ponvert,

Douglas R. Ollerenshaw

и другие.

Neuron, Год журнала: 2024, Номер 112(11), С. 1876 - 1890.e4

Опубликована: Март 5, 2024

In complex environments, animals can adopt diverse strategies to find rewards. How distinct differentially engage brain circuits is not well understood. Here, we investigate this question, focusing on the cortical Vip-Sst disinhibitory circuit between vasoactive intestinal peptide-postive (Vip) interneurons and somatostatin-positive (Sst) interneurons. We characterize behavioral used by mice during a visual change detection task. Using dynamic logistic regression model, that individual use mixtures of comparison strategy statistical timing strategy. Separately, also have periods task engagement disengagement. Two-photon calcium imaging shows large strategy-dependent differences in neural activity excitatory, Sst inhibitory, Vip inhibitory cells response both image changes omissions. contrast, has limited effects population activity. diversity correlates be understood parsimoniously as increased activation strategy, which facilitates task-appropriate responses.

Язык: Английский

Процитировано

11
Mixtures of strategies underlie rodent behavior during reversal learning DOI Creative Commons
Nhat Minh Le, Murat Yıldırım, Yizhi Wang

и другие.

PLoS Computational Biology, Год журнала: 2023, Номер 19(9), С. e1011430 - e1011430

Опубликована: Сен. 14, 2023

In reversal learning tasks, the behavior of humans and animals is often assumed to be uniform within single experimental sessions facilitate data analysis model fitting. However, agents can display substantial variability in sessions, as they execute different blocks trials with transition dynamics. Here, we observed that a deterministic task, mice noisy sub-optimal choice transitions even at expert stages learning. We investigated two sources sub-optimality behavior. First, found exhibit high lapse rate during task execution, reverted unrewarded directions after transitions. Second, unexpectedly majority did not strategy, but rather mixed between several behavioral modes quantified use such mixtures state-space model, block Hidden Markov Model (block HMM), dissociate dynamic individual trials. Additionally, blockHMM rodent accounted for by types algorithms, model-free or inference-based learning, might used solve task. Combining these approaches, mixture both exploratory, strategies deterministic, explaining their overall sequences. Together, our combined computational approach highlights intrinsic noise provides richer description than conventional techniques, while uncovering hidden states underlie block-by-block

Язык: Английский

Процитировано

15
An entorhinal-like region in food-caching birds DOI Creative Commons
Marissa C. Applegate,

Konstantin S. Gutnichenko,

Emily L. Mackevicius

и другие.

Current Biology, Год журнала: 2023, Номер 33(12), С. 2465 - 2477.e7

Опубликована: Июнь 1, 2023

Язык: Английский

Процитировано

13
Flexible gating between subspaces in a neural network model of internally guided task switching DOI Creative Commons
Yue Liu, Xiao‐Jing Wang

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 1, 2024

Behavioral flexibility relies on the brain's ability to switch rapidly between multiple tasks, even when task rule is not explicitly cued but must be inferred through trial and error. The underlying neural circuit mechanism remains poorly understood. We investigated recurrent networks (RNNs) trained perform an analog of classic Wisconsin Card Sorting Test. consist two modules responsible for representation sensorimotor mapping, respectively, where each module comprised a with excitatory neurons three major types inhibitory neurons. found that by self-sustained persistent activity across trials, error monitoring gated mapping emerged from training. Systematic dissection RNNs revealed detailed consistent different hyperparameters. networks' dynamical trajectories rules resided in separate subspaces population activity; collapsed performance was reduced chance level dendrite-targeting somatostatin-expressing interneurons were silenced, illustrating how phenomenological description representational explained specific mechanism. flexible switching unclear. Here authors analyzed modular network models cell reveal uncued switching.

Язык: Английский

Процитировано

4
Stimulus information guides the emergence of behavior-related signals in primary somatosensory cortex during learning DOI Creative Commons
Mariangela Panniello, Colleen J. Gillon, Roberto Maffulli

и другие.

Cell Reports, Год журнала: 2024, Номер 43(6), С. 114244 - 114244

Опубликована: Май 25, 2024

Neurons in the primary cortex carry sensory- and behavior-related information, but it remains an open question how this information emerges intersects together during learning. Current evidence points to two possible learning-related changes: sensory increases or stable, its readout efficiency association cortices increases. We investigated by imaging neuronal activity mouse somatosensory before, during, after learning of object localization task. quantified estimated much was used instruct perceptual choices as progressed. find that from start training, while choice is mostly present later stages Additionally, becomes more efficient with early cortex. Together, our results highlight importance cortical neurons

Язык: Английский

Процитировано

3