Synapses-associated research in Parkinson’s disease: an explored trends analysis

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Апрель 2, 2025

The pathological features of Parkinson's disease (PD) include the formation Lewy bodies composed mainly aggregated alpha-synuclein (α-Syn) and extensive neurodegeneration. Synaptic dysfunction is a key factor contributing to progression among various cellular molecular mechanisms PD. This study aims analyze research hotspots, frontier trends, future directions PD synapses. Relevant publications were obtained using Web Science database. Software CiteSpace, VOSviewer, bibliometrix used for visualization quantitative analysis. A total 3,823 included analysis, number related topic showed an increasing trend from 2001 2024. North America, Asia, Europe main forces with high activity. United States was leader in this field, followed by China Italy. Emory University institution largest publications. Journal Neuroscience core journal large Dr. Calabresi, Paolo field research. High-frequency keywords PD, α-Syn, synaptic plasticity, basal ganglia, dopamine, substantia-nigra. In recent years, neuroinflammation has been subject active Communication collaboration between different countries, institutions, authors have promoted development field. content focused on mouse model. Neuroinflammation may be direction

Язык: Английский

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Attention Deficit-Hyperactivity Disorder (ADHD): From Abnormal Behavior to Impairment in Synaptic Plasticity

Biology, Год журнала: 2023, Номер 12(9), С. 1241 - 1241

Опубликована: Сен. 15, 2023

Attention deficit-hyperactivity disorder (ADHD) is a neurodevelopmental with high incidence in children and adolescents characterized by motor hyperactivity, impulsivity, inattention. Magnetic resonance imaging (MRI) has revealed that neuroanatomical abnormalities such as the volume reduction neocortex hippocampus are shared several neuropsychiatric diseases schizophrenia, autism spectrum ADHD. Furthermore, abnormal development postnatal pruning of dendritic spines neocortical neurons intellectual disability well documented. Dendritic dynamic structures exhibiting Hebbian homeostatic plasticity triggers intracellular cascades involving glutamate receptors, calcium influx remodeling F-actin network. The long-term potentiation (LTP)-induced insertion postsynaptic receptors associated enlargement spine heads depression (LTD) shrinkage. Using murine model ADHD, delay spines’ maturation CA1 hippocampal correlated impaired working memory LTP recently reported. aim this review to summarize recent evidence emerged from studies focused on genetic features found ADHD patients reports animal models describing molecular structure spines.

Язык: Английский

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Cell-Type Specific Connectivity of Whisker-Related Sensory and Motor Cortical Input to Dorsal Striatum

eNeuro, Год журнала: 2023, Номер 11(1), С. ENEURO.0503 - 23.2023

Опубликована: Дек. 27, 2023

The anterior dorsolateral striatum (DLS) is heavily innervated by convergent excitatory projections from the primary motor (M1) and sensory cortex (S1) considered an important site of sensorimotor integration. M1 S1 corticostriatal synapses have functional differences in their connection strength with striatal spiny projection neurons (SPNs) fast-spiking interneurons (FSIs) DLS and, as a result, exert distinct influences on sensory-guided behaviors. In present study, we tested whether inputs exhibit subcellular anatomical distribution neurons. We injected adeno-associated viral vectors encoding spaghetti monster fluorescent proteins (sm.FPs) into male female mice used confocal microscopy to generate 3D reconstructions single identified SPNs FSIs obtained through ex vivo patch clamp electrophysiology. found that dually innervate FSIs; however, there consistent bias towards input not FSIs. addition, were distributed similarly across proximal, medial, distal regions SPN FSI dendrites. Notably, closely localized clusters more prevalent than FSIs, suggesting cortical are integrated cell-type specific mechanisms. Our results suggest stronger connectivity compared S1, previously observed, due higher quantity synaptic inputs. implications for how integration performed cell-specific connections.

Язык: Английский

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Meandering Sobriety

Опубликована: Апрель 18, 2023

The Kindle book can be ordered for $3.21 from Amazon: https://www.amazon.com/dp/B0C2TXNX6LIn the hyper-chaotic infosphere today, we are surrounded by noises of information, not only as wavy shores or waterfalls but also mega-tsunamis, through Twitter, Facebook, Tiktok, Instagram, Youtube, etc. More than ever, tranquility and calmness necessary. Like what you have seen in wilderness video clips, predators such lions, bears, alligators act lightning-fast when catching prey. But food is served, natural world returns to its peaceful, soothing silence.This short own tidy infosphere, where each little story brief self-contained. Despite this small appearance, I hope content inside carries value life observation. petite, pretty sure malnourished. A not-too-small detail that way was shaped distilled reflects some innovations mine my research team: mindsponge theory, a new theory serendipity, bayesvl R package, BMF analytics, well other experiences working field science. After all, scientific works were main source (before sells – if it does).Much content, seemingly fragmented, has reflected our lab’s essential cultural values, which led analytics related works. Thus, under analytical paradigm these closely-connected concepts, pieces come together bits one whole thing. think bit unfair tell about things house without mentioning itself.Welcome priceless sober moments with chicken-burger price tag!I will bring readers calmness, peaceful smiles, maybe couple good laughs too.

Язык: Английский

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Neurophysiological and Clinical Effects of Upper Limb Robot-Assisted Rehabilitation on Motor Recovery in Patients with Subacute Stroke: A Multicenter Randomized Controlled Trial Study Protocol

Brain Sciences, Год журнала: 2023, Номер 13(4), С. 700 - 700

Опубликована: Апрель 21, 2023

The efficacy of upper limb (UL) robot-assisted therapy (RAT) on functional improvement after stroke remains unclear. However, recently published randomized controlled trials have supported its potential benefits in enhancing the activities daily living, arm and hand function, muscle strength. Task-specific high-intensity exercises are key points facilitating motor re-learning neurorehabilitation since RAT can provide an assisted-as-needed approach. This study aims to investigate clinical effects exoskeleton robotic system for UL rehabilitation compared with conventional (CT) people subacute stroke. As a secondary aim, we seek identify patients' characteristics, which predict better recovery UL-RAT detects whether it could elicit greater brain stimulation.A total 84 patients will be recruited from 7 Italian centers over 3 years. randomly allocated either CT (control group, CG) or plus UL-RT through Armeo®Power (Hocoma AG, CH, Volketswil, Switzerland) (experimental EG). A sample stratification based distance onset, DSO (DSO ≤ 30; > 30), Fugl-Meyer Assessment (FM)-UL (FM-UL 22; 22 < FM-UL 44) considered randomization. outcomes recorded at baseline (T0), 25 + sessions intervention (T1), 6 months post-stroke (T2). functioning assessed by (0-66) primary outcome. assessments set International Classification Function, Disability Health (ICF). patient satisfaction questionnaire evaluated EG T1. subgroup T0 T1 via electroencephalography. Their electrical activity during rest conditions their eyes closed open (5 min each).The results this trial in-depth understanding early whole how may relate neural plasticity process. was registered ClinicalTrial.gov registration identifier NCT04697368.

Язык: Английский

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