Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina DOI Open Access

Sidney P. Kuo,

Wan‐Qing Yu, Prerna Srivastava

и другие.

Опубликована: Авг. 20, 2024

Parallel processing is a fundamental organizing principle in the nervous system, and understanding how parallel neural circuits generate distinct outputs from common inputs key goal of neuroscience. In mammalian retina, divergence cone signals into multiple feed-forward bipolar cell pathways forms initial basis for retinal dedicated to specific visual functions. Here, we used patch-clamp electrophysiology, electron microscopy two photon imaging fluorescent glutamate sensor examine kinetically responses arise transient versus sustained ON alpha RGCs (ON-T ON-S RGCs) mouse retina. We directly compared response properties these with their presynaptic partners, which identified using 3D reconstruction. Different subtypes (type 5i, type 6 7) had indistinguishable light-driven whereas extracellular around RGC dendrites postsynaptic excitatory currents measured ON-T identical stimuli probe cells were distinct. Anatomical examination axon terminals suggests subtype-specific differences size synaptic ribbon-associated vesicle pools may contribute kinetics. Our findings indicate synapses are primary point pathways.

Язык: Английский

Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells DOI Creative Commons
Le Chang,

Yanli Ran,

Mingpo Yang

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Янв. 10, 2024

In the vertebrate retina, several dozens of parallel channels relay information about visual world to brain. These are represented by different types retinal ganglion cells (RGCs), whose responses rendered selective for distinct sets features various mechanisms. mechanisms can be roughly grouped into synaptic interactions and cell-intrinsic mechanisms, with latter including dendritic morphology as well ion channel complement distribution. Here, we investigate how strongly shape RGC output comparing two mouse types, well-described ON alpha cell a little-studied that is EGFP-labelled in

Язык: Английский

Процитировано

6
High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons DOI Creative Commons
Helen Gooch, Tobias Bluett, Madhusoothanan B. Perumal

и другие.

Cell Reports, Год журнала: 2022, Номер 41(3), С. 111500 - 111500

Опубликована: Окт. 1, 2022

Dendritic spikes function as cardinal components of rodent neocortical circuit computations. Recently, the biophysical properties human pyramidal neurons (PNs) have been reported to be divergent, raising question whether dendritic homologous roles in neocortex. To directly address this, we made electrical recordings from soma and apical dendrites rat layer 2/3 PNs temporal cortex. In both species, excitatory input led initiation sodium-channel-mediated spikes. sodium could generated across a wide range, exhibited similar frequency range activation, forward-propagated with high-fidelity implement stereotyped computations PNs. However, physical expansion complexification trees allowed enriched expression spike generation. The computational capacity is therefore enhanced by widespread implementation conserved integration mechanism.

Язык: Английский

Процитировано

18
Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina DOI Creative Commons

Sidney P. Kuo,

Wan‐Qing Yu, Prerna Srivastava

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 14, 2024

Abstract Parallel processing is a fundamental organizing principle in the nervous system, and understanding how parallel neural circuits generate distinct outputs from common inputs key goal of neuroscience. In mammalian retina, divergence cone signals into multiple feed-forward bipolar cell pathways forms initial basis for retinal dedicated to specific visual functions. Here, we used patch-clamp electrophysiology, electron microscopy two photon imaging fluorescent glutamate sensor examine kinetically responses arise transient versus sustained ON alpha RGCs (ON-T ON-S RGCs) mouse retina. We directly compared response properties these with their presynaptic partners, which identified using 3D reconstruction. Different subtypes (type 5i, type 6 7) had indistinguishable light-driven whereas extracellular around RGC dendrites postsynaptic excitatory currents measured ON-T identical stimuli probe cells were distinct. Anatomical examination axon terminals suggests subtype-specific differences size synaptic ribbon-associated vesicle pools may contribute kinetics. Our findings indicate synapses are primary point pathways.

Язык: Английский

Процитировано

3
Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina DOI Open Access

Sidney P. Kuo,

Wan‐Qing Yu, Prerna Srivastava

и другие.

Опубликована: Авг. 20, 2024

Parallel processing is a fundamental organizing principle in the nervous system, and understanding how parallel neural circuits generate distinct outputs from common inputs key goal of neuroscience. In mammalian retina, divergence cone signals into multiple feed-forward bipolar cell pathways forms initial basis for retinal dedicated to specific visual functions. Here, we used patch-clamp electrophysiology, electron microscopy two photon imaging fluorescent glutamate sensor examine kinetically responses arise transient versus sustained ON alpha RGCs (ON-T ON-S RGCs) mouse retina. We directly compared response properties these with their presynaptic partners, which identified using 3D reconstruction. Different subtypes (type 5i, type 6 7) had indistinguishable light-driven whereas extracellular around RGC dendrites postsynaptic excitatory currents measured ON-T identical stimuli probe cells were distinct. Anatomical examination axon terminals suggests subtype-specific differences size synaptic ribbon-associated vesicle pools may contribute kinetics. Our findings indicate synapses are primary point pathways.

Язык: Английский

Процитировано

1
Plaid masking explained with input-dependent dendritic nonlinearities DOI Creative Commons
Marcelo Bertalmı́o,

Alexia Durán Vizcaíno,

Jesús Malo

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 22, 2024

Abstract A serious obstacle for understanding early spatial vision comes from the failure of so-called standard model (SM) to predict perception plaid masking. But SM originated a major oversimplification single neuron computations, ignoring fundamental properties dendrites. Here we show that including computations mimicking input-dependent nature dendritic nonlinearities, i.e. nonlinear neural summation, has potential explain masking data.

Язык: Английский

Процитировано

1
Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina DOI Open Access

Sidney P. Kuo,

Wan‐Qing Yu, Prerna Srivastava

и другие.

Опубликована: Авг. 20, 2024

Parallel processing is a fundamental organizing principle in the nervous system, and understanding how parallel neural circuits generate distinct outputs from common inputs key goal of neuroscience. In mammalian retina, divergence cone signals into multiple feed-forward bipolar cell pathways forms initial basis for retinal dedicated to specific visual functions. Here, we used patch-clamp electrophysiology, electron microscopy two photon imaging fluorescent glutamate sensor examine kinetically responses arise transient versus sustained ON alpha RGCs (ON-T ON-S RGCs) mouse retina. We directly compared response properties these with their presynaptic partners, which identified using 3D reconstruction. Different subtypes (type 5i, type 6 7) had indistinguishable light-driven whereas extracellular around RGC dendrites postsynaptic excitatory currents measured ON-T identical stimuli probe cells were distinct. Anatomical examination axon terminals suggests subtype-specific differences size synaptic ribbon-associated vesicle pools may contribute kinetics. Our findings indicate synapses are primary point pathways.

Язык: Английский

Процитировано

0