The zona incerta regulates burying behavior and normalizes anxiety-like behavior in inescapable stressful male mice by object cue DOI Creative Commons

Yueqin Liu,

Lianli Qiu,

Jiahui Qian

и другие.

Neurobiology of Stress, Год журнала: 2024, Номер 34, С. 100704 - 100704

Опубликована: Дек. 17, 2024

Inescapable stressful events often precipitate long-term alterations in emotion-related behaviors and poor sleep quality, with anxiety being a prevalent associated disorder. The defensive burying behavior of rodents is response to imminent threats that becomes markedly pronounced anxiety. However, the neural foundations etiology remain largely unknown. In this study, we established model employing object binding elicit increased mice, thereby enhancing fear resolution subsequently reducing anxious behaviors. Notably, mice shock an exhibited less exploration zona incerta (ZI) neurons showed higher calcium activity during as compared Shock only mice. Although ZI Object was identical more behavior. Furthermore, time spent center open-field test directly proportional duration Chemogenetic activation extended concomitantly ameliorated anxiety-like Importantly, chemogenetic enhancement projection from ventral periaqueductal gray (vPAG), brain region plays critical role autonomic function, normalizes without influencing Collectively, these findings systematically reveal functions underlying mechanisms ZI-vPAG circuit controlling akin anxiety, offering significant insights into ZI's pathophysiology disorders.

Язык: Английский

Neurobiology of Obsessive–Compulsive Disorder from Genes to Circuits: Insights from Animal Models DOI
Ying-Dan Zhang, Dongdong Shi, Zhen Wang

и другие.

Neuroscience Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Июль 9, 2024

Язык: Английский

Процитировано

2
Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure DOI
Tong Jiang, Mengyang Feng,

Alexander Hutsell

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 9, 2024

ABSTRACT Clinical and preclinical studies have identified somatostatin (SST)-positive interneurons as key elements that regulate the vulnerability to stress-related psychiatric disorders. Conversely, disinhibition of SST neurons in mice results resilience behavioral effects chronic stress. Here we established a low-dose chemogenetic protocol map these changes positively negatively motivated behaviors specific brain regions. AAV-hM3Dq mediated activation prelimbic cortex (PLC) had antidepressant drug-like on anxiety- anhedonia-like male but not female mice. Analogous manipulation ventral hippocampus (vHPC) such Moreover, PLC vHPC resulted stress resilience. Activation reversed prior stress-induced defects behavior males was ineffective females. alterations females males. Quantitation c-Fos + FosB stress-exposed revealed leads paradoxical increase pyramidal cell activity. Collectively, data demonstrate GABAergic microcircuits driven by dendrite targeting enable sex- brain-region-specific neural plasticity promotes reverses behavior. Our provide mechanistic rationale for efficacy dendrite-targeting, low-potency GABA A receptor agonists, independent sex despite striking differences relevant substrates.

Язык: Английский

Процитировано

2
Ventral zona incerta parvalbumin neurons modulate sensory-induced and stress-induced self-grooming via input-dependent mechanisms in mice DOI Creative Commons
Junye Ge, Pengfei Ren,

Biqing Tian

и другие.

iScience, Год журнала: 2024, Номер 27(7), С. 110165 - 110165

Опубликована: Июнь 4, 2024

Язык: Английский

Процитировано

1
Alleviation of Autophagic Deficits and Neuroinflammation by Histamine H3 Receptor Antagonist E159 Ameliorates Autism-Related Behaviors in BTBR Mice DOI Creative Commons
Shilu Deepa Thomas, Petrilla Jayaprakash,

Nurfirzana Z. H. J. Marwan

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1293 - 1293

Опубликована: Сен. 28, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by social interaction difficulties, repetitive behaviors, and immune dysregulation with elevated pro-inflammatory markers. Autophagic deficiency also contributes to behavior deficits in ASD. Histamine H3 receptor (H3R) antagonism potential treatment strategy for brain disorders features overlapping ASD, such as schizophrenia Alzheimer's disease.

Язык: Английский

Процитировано

1
The zona incerta regulates burying behavior and normalizes anxiety-like behavior in inescapable stressful male mice by object cue DOI Creative Commons

Yueqin Liu,

Lianli Qiu,

Jiahui Qian

и другие.

Neurobiology of Stress, Год журнала: 2024, Номер 34, С. 100704 - 100704

Опубликована: Дек. 17, 2024

Inescapable stressful events often precipitate long-term alterations in emotion-related behaviors and poor sleep quality, with anxiety being a prevalent associated disorder. The defensive burying behavior of rodents is response to imminent threats that becomes markedly pronounced anxiety. However, the neural foundations etiology remain largely unknown. In this study, we established model employing object binding elicit increased mice, thereby enhancing fear resolution subsequently reducing anxious behaviors. Notably, mice shock an exhibited less exploration zona incerta (ZI) neurons showed higher calcium activity during as compared Shock only mice. Although ZI Object was identical more behavior. Furthermore, time spent center open-field test directly proportional duration Chemogenetic activation extended concomitantly ameliorated anxiety-like Importantly, chemogenetic enhancement projection from ventral periaqueductal gray (vPAG), brain region plays critical role autonomic function, normalizes without influencing Collectively, these findings systematically reveal functions underlying mechanisms ZI-vPAG circuit controlling akin anxiety, offering significant insights into ZI's pathophysiology disorders.

Язык: Английский

Процитировано

1