Cell Reports,
Год журнала:
2024,
Номер
43(4), С. 114014 - 114014
Опубликована: Апрель 1, 2024
The
transmembrane
channel-like
(TMC)
protein
family
comprises
eight
members,
with
TMC1
and
TMC2
being
extensively
studied.
This
study
demonstrates
substantial
co-expression
of
TMC7
the
mechanosensitive
channel
Piezo2
in
somatosensory
neurons.
Genetic
deletion
primary
sensory
ganglia
neurons
vivo
enhances
sensitivity
both
physiological
pathological
mechanosensory
transduction.
leads
to
an
increase
proportion
rapidly
adapting
(RA)
currents
conducted
by
dorsal
root
ganglion
(DRG)
accelerates
RA
deactivation
kinetics.
In
HEK293
cells
expressing
proteins,
significantly
suppresses
current
amplitudes
co-expressed
Piezo2.
Our
findings
reveal
that
exhibit
physical
interactions,
proteins
also
physically
interact
cytoskeletal
β-actin.
We
hypothesize
functions
as
inhibitory
modulator
DRG
neurons,
either
through
direct
inhibition
or
disrupting
transmission
mechanical
forces
from
cytoskeleton
channel.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 833 - 833
Опубликована: Июль 11, 2024
Microglia,
as
resident
macrophages
in
the
central
nervous
system,
play
a
multifunctional
role
pathogenesis
of
Alzheimer’s
disease
(AD).
Their
clustering
around
amyloid-β
(Aβ)
deposits
is
core
pathological
feature
AD.
Recent
advances
single-cell
RNA
sequencing
(scRNA-seq)
and
single-nucleus
(snRNA-seq)
have
revealed
dynamic
changes
microglial
phenotypes
over
time
across
different
brain
regions
during
aging
AD
progression.
As
advances,
microglia
primarily
exhibit
impaired
phagocytosis
Aβ
tau,
along
with
release
pro-inflammatory
cytokines
that
damage
synapses
neurons.
Targeting
has
emerged
potential
therapeutic
approach
for
Treatment
strategies
involving
can
be
broadly
categorized
into
two
aspects:
(1)
enhancing
function:
This
involves
augmenting
their
phagocytic
ability
against
cellular
debris
(2)
mitigating
neuroinflammation:
Strategies
include
inhibiting
TNF-α
signaling
to
reduce
neuroinflammatory
response
triggered
by
microglia.
Clinical
trials
exploring
microglia-related
approaches
treatment
garnered
attention.
Additionally,
natural
products
show
promise
beneficial
effects
suppressing
inflammatory
responses.
Clarifying
dynamics,
understanding
roles,
novel
will
advance
our
fight
Cell Reports,
Год журнала:
2024,
Номер
43(4), С. 114014 - 114014
Опубликована: Апрель 1, 2024
The
transmembrane
channel-like
(TMC)
protein
family
comprises
eight
members,
with
TMC1
and
TMC2
being
extensively
studied.
This
study
demonstrates
substantial
co-expression
of
TMC7
the
mechanosensitive
channel
Piezo2
in
somatosensory
neurons.
Genetic
deletion
primary
sensory
ganglia
neurons
vivo
enhances
sensitivity
both
physiological
pathological
mechanosensory
transduction.
leads
to
an
increase
proportion
rapidly
adapting
(RA)
currents
conducted
by
dorsal
root
ganglion
(DRG)
accelerates
RA
deactivation
kinetics.
In
HEK293
cells
expressing
proteins,
significantly
suppresses
current
amplitudes
co-expressed
Piezo2.
Our
findings
reveal
that
exhibit
physical
interactions,
proteins
also
physically
interact
cytoskeletal
β-actin.
We
hypothesize
functions
as
inhibitory
modulator
DRG
neurons,
either
through
direct
inhibition
or
disrupting
transmission
mechanical
forces
from
cytoskeleton
channel.
