Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and exploration DOI Creative Commons
Charles K. Dowell, Thomas Hawkins, Isaac H. Bianco

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 12, 2024

Abstract Animals construct diverse behavioural repertoires by moving a limited number of body parts with varied kinematics and patterns coordination. There is evidence that distinct movements can be generated changes in activity dynamics within common pool motoneurons, or selectively engaging specific subsets motoneurons task-dependent manner. However, most cases we have an incomplete understanding the motoneuron generate actions how upstream premotor circuits select assemble such motor programmes. In this study, used two closely related but kinematically types saccadic eye movement larval zebrafish as model to examine circuit control diversity. contrast prevailing view final pathway, found oculomotor nucleus, were engaged for each saccade type. This type-specific recruitment was topographically organised aligned ultrastructural differ-ences morphology afferent synaptic innervation. Medially located motoneu-rons active both tracing revealed type-agnostic pathway appears their recruitment. By contrast, laterally subset specifically hunting-associated saccades received in-put from pretectal hunting command neurons. Our data support which generalist action-specific pathways engage elicit same part subserve functions.

Язык: Английский

Determinants of motor neuron functional subtypes important for locomotor speed DOI Creative Commons
Kristen P. D’Elia, Hanna Hameedy, Dena Goldblatt

и другие.

Cell Reports, Год журнала: 2023, Номер 42(9), С. 113049 - 113049

Опубликована: Сен. 1, 2023

Locomotion requires precise control of the strength and speed muscle contraction is achieved by recruiting functionally distinct subtypes motor neurons (MNs). MNs are essential to movement differentially susceptible in disease, but little known about how acquire functional subtype-specific features during development. Using single-cell RNA profiling embryonic larval zebrafish, we identify novel conserved molecular signatures for MN genes expressed both early post-mitotic mature MNs. Assessing development genetic mutants, define a program subtype specification. Two evolutionarily transcription factors, Prdm16 Mecom, determinants integral fast Loss prdm16 or mecom causes develop transcriptional profiles innervation similar slow These results reveal diversity vertebrate axial demonstrate that specified through intrinsic codes.

Язык: Английский

Процитировано

31
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish DOI Creative Commons
Martin Carbó-Tano, Mathilde Lapoix, Xinyu Jia

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(10), С. 1775 - 1790

Опубликована: Сен. 4, 2023

Abstract The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers graded forward locomotion. How MLR neurons recruit downstream vsx2 + (V2a) reticulospinal (RSNs) poorly understood. Here, to overcome this challenge, we uncovered the locus of in transparent larval zebrafish and show that distinct from nucleus medial longitudinal fasciculus. stimulations reliably elicit locomotion controlled duration frequency. V2a RSNs via projections onto somata pontine retropontine areas, dendrites medulla. High-speed volumetric imaging neuronal activity reveals strongly MLR-coupled are active for steering or swimming, whereas weakly medullary encode frequency component. Our study demonstrates how specific control kinematics suggests conservation motor functions across vertebrates.

Язык: Английский

Процитировано

24
Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and exploration DOI Creative Commons
Charles K. Dowell, Thomas Hawkins, Isaac H. Bianco

и другие.

Current Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Modular circuit organization for speed control of locomotor movements DOI Open Access
Abdeljabbar El Manira

Current Opinion in Neurobiology, Год журнала: 2023, Номер 82, С. 102760 - 102760

Опубликована: Авг. 17, 2023

Язык: Английский

Процитировано

18
Separate brainstem circuits for fast steering and slow exploratory turns DOI Creative Commons
Lulu Xu, Bing Zhu, Zhiqiang Zhu

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 3, 2025

Abstract Locomotion requires precise tuning of descending commands to scale turning movements, such as rapid steering during prey pursuit or shallow turns exploration. We show that these two turn types are governed by distinct brainstem circuits. The circuit involves excitatory V2a and inhibitory commissural V0d neurons, distributed across different nuclei. These neurons coupled via gap junctions activated simultaneously, ensuring through asymmetrical activation spinal motor neurons. recruitment this correlates more with the degree direction change than locomotor frequency. Steering are, in turn, controlled a subset pretectum, salient visual input. In contrast, slow exploratory separate set confined fewer findings reveal modular organization circuits selectively control locomotion.

Язык: Английский

Процитировано

1
Degenerate Neuronal and Circuit Mechanisms Important for Generating Rhythmic Motor Patterns DOI
Ronald L. Calabrese, Eve Marder

Physiological Reviews, Год журнала: 2024, Номер 105(1), С. 95 - 135

Опубликована: Июнь 13, 2024

In 1996, we published a review article (Marder E, Calabrese RL.

Язык: Английский

Процитировано

6
Control of movement of underwater swimmers: Animals, simulated animates and swimming robots DOI
Susanna Gordleeva, Innokentiy Kastalskiy, Yuliya Tsybina

и другие.

Physics of Life Reviews, Год журнала: 2023, Номер 47, С. 211 - 244

Опубликована: Ноя. 7, 2023

Язык: Английский

Процитировано

13
Hierarchical behavior control by a single class of interneurons DOI Creative Commons
Jing Huo, Tianqi Xu, Qi Liu

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(47)

Опубликована: Ноя. 12, 2024

Animal behavior is organized into nested temporal patterns that span multiple timescales. This hierarchy believed to arise from a hierarchical neural architecture: Neurons near the top of are involved in planning, selecting, initiating, and maintaining motor programs, whereas those bottom act concert produce fine spatiotemporal activity. In Caenorhabditis elegans , on long timescale emerges ordered flexible transitions between different behavioral states, such as forward, reversal, turn. On short timescale, parts animal body coordinate fast rhythmic bending sequences directional movements. Here, we show Sublateral Anterior A (SAA), class interneurons enable cross-communication dorsal ventral head neurons, play dual role shaping dynamics SAA regulate stabilize activity during forward same neurons suppress spontaneous reversals facilitate reversal termination by inhibiting Ring Interneuron M (RIM), an integrating neuron helps maintain state. These results suggest feedback lower-level cell assembly higher-level command center essential for bridging at levels.

Язык: Английский

Процитировано

5
A brainstem circuit for gravity-guided vertical navigation DOI Creative Commons
Yunlu Zhu, Hannah Gelnaw, Franziska Auer

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 13, 2024

ABSTRACT The sensation of gravity anchors our perception the environment and is crucial for navigation. However, neural circuits that transform into commands navigation are undefined. We first determined larval zebrafish ( Danio rerio ) navigate vertically by maintaining a consistent heading across series upward climb or downward dive bouts. Gravity-blind mutant fish swim with more variable excessive veering, leading to inefficient vertical After targeted photoablation ascending vestibular neurons spinal projecting midbrain neurons, but not vestibulospinal was impaired. These data define sensorimotor circuit uses evolutionarily-conserved brainstem architecture gravitational signals persistent work lays foundation understand how inputs allow animals move efficiently through their environment.

Язык: Английский

Процитировано

4
The vestibulospinal nucleus is a locus of balance development DOI
Kyla R. Hamling, Katherine Harmon, Yukiko Kimura

и другие.

Journal of Neuroscience, Год журнала: 2024, Номер 44(30), С. e2315232024 - e2315232024

Опубликована: Май 22, 2024

Mature vertebrates maintain posture using vestibulospinal neurons that transform sensed instability into reflexive commands to spinal motor circuits. Postural stability improves across development. However, due the complexity of terrestrial locomotion, contributions postural refinement in early life remain unexplored. Here we leveraged relative simplicity underwater locomotion quantify consequences losing during development larval zebrafish undifferentiated sex. By comparing at two timepoints, discovered later lesions led greater instability. Analysis thousands individual swim bouts revealed disrupted movement timing and corrective reflexes without impacting kinematics, this effect was particularly strong older larvae. Using a generative model swimming, showed how these disruptions could account for increased variability both timepoints. Finally, late fin/trunk coordination observed larvae, linking control schemes used navigate depth. Since were considerably more disruptive stability, conclude balance increase as larvae mature. Vestibulospinal are highly conserved vertebrates; therefore propose they substrate developmental improvements control.

Язык: Английский

Процитировано

4